What is Carbidopa-Entacapone-Levodopa?

Category: Prescription Drugs

Most popular types: Stalevo Stalevo 100 Stalevo 150 Show all

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The combination of levodopa, carbidopa, and entacapone is used for Parkinson's Disease. Levodopa is the precursor to dopamine, carbidopa slows the breakdown of levodopa, while entacapone improves the efficacy of levodopa.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 629 278
Stiffness/spasticity 20 10
Increase effect of another treatment 14 12
Improve mobility 5 4
Tremor in hands 4 2
Slow movement (bradykinesia) 3 0

Show all 27 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
32
Moderate
66
Mild
72
None
117

Commonly reported side effects and conditions associated with Carbidopa-Entacapone-Levodopa

Side effect Patients
Jerky movements 36
Nausea 15
Cramps in legs 8
Wearing off increased tremors 8
Dry mouth 7
Weight gain 6

Show all 95 reported side effects

Dosages

Based on patients currently taking Carbidopa-Entacapone-Levodopa

Dosage Patients
25 mg-200 mg-100 mg daily 6
3 x 25 mg-200 mg-100 mg daily 5
50-200-200 mg three times daily 4
12.5-200-50 mg three times daily 3
37.5-200-150 mg four times daily 3
25 mg-200 mg-100 mg four times daily 3
4 x 37.5 mg-200 mg-150 mg daily 3
25-200-100 mg twice daily 2
25-200-100 mg three times daily 2
31.25-200-125 mg three times daily 2

See all 58 dosages

Why patients stopped taking Carbidopa-Entacapone-Levodopa

Multiple reasons could be selected

Reason Patients
Side effects too severe 69
Doctor's advice 64
Did not seem to work 39
Other 33
Expense 21
Personal research 9
Change in health plan coverage 3
Course of treatment ended 1
See all 189 patients who've stopped taking Carbidopa-Entacapone-Levodopa

Duration

Currently taking Carbidopa-Entacapone-Levodopa

Duration Patients
Less than 1 month 1
1 - 6 months 1
6 months - 1 year 4
1 - 2 years 9
2 - 5 years 16
5 - 10 years 46
10 years or more 11

Stopped taking Carbidopa-Entacapone-Levodopa

Duration Patients
Less than 1 month 26
1 - 6 months 58
6 months - 1 year 35
1 - 2 years 22
2 - 5 years 48
5 - 10 years 11
10 years or more 3
Adherence
Adherence Evaluations
Always 218
Usually 51
Sometimes 7
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 16
Somewhat hard to take 32
A little hard to take 58
Not at all hard to take 181
Cost per month
Cost per month Evaluations
$200+ 17
$100-199 15
$50-99 29
$25-49 40
< $25 90
Not specified 96

What people switch to and from

Patients started taking Carbidopa-Entacapone-Levodopa after stopping:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 32
Ropinirole (Requip) 8
Amantadine (Symmetrel) 3
Carbidopa Levodopa ER (Rytary XR) 3
Pramipexole (Mirapex) 3

Show all 10 treatments patients report switching from

Patients stopped taking Carbidopa-Entacapone-Levodopa and switched to:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 13
Carbidopa Levodopa ER (Rytary XR) 8
Entacapone (Comtan) 3
Carbidopa-Levodopa CR (Sinemet CR) 2
Pramipexole (Mirapex) 2

Show all 9 treatments patients report switching to

Last updated:

42 patient evaluations for Carbidopa-Entacapone-Levodopa

Jun 19, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12.5-200-50 mg Three times daily

  • 0 helpful marks

Jun 13, 2017 (Started May 19, 2017)

  • Effectiveness
    None (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50-200-200 mg Five times daily
Advice & Tips: I have advanced pd. We were hoping it might help me a little bit more than Rytary. It didn't.
Cost: $200+ monthly

  • 0 helpful marks

Sep 14, 2016 (Started Mar 09, 2016)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Severe (nausea)
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Advice & Tips: stopped taking drug. Possible diarrhea problems caused by this
Cost: < $25 monthly

Jul 13, 2016 (Started Mar 09, 2016)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (nausea)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Advice & Tips: No changes
Cost: < $25 monthly

Jun 15, 2016 (Started Mar 09, 2016)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Severe (nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 37.5 mg-200 mg-150 mg Five times daily
Advice & Tips: Diarrhea
Cost: < $25 monthly

Mar 9, 2016 (Started Mar 09, 2016)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 5 x 37.5 mg-200 mg-150 mg Daily
Advice & Tips: I eat crackers with medicine.
Cost: < $25 monthly

Nov 18, 2015 (Started Mar 09, 2016)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Advice & Tips: I eat crackers before taking my medicine
Cost: < $25 monthly

Sep 16, 2015 (Started Mar 09, 2016)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 42 patient evaluations for Carbidopa-Entacapone-Levodopa