What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 464 357
Fibromyalgia 158 238
Fatigue 129 186
Pain 46 60
Amyotrophic lateral sclerosis 39 37
Myalgic encephalomyelitis/chronic fatigue syndrome 36 93

Show all 179 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 38
Moderate 55
Mild 216
None 590

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 28
Nausea 17
Headaches 12
Insomnia 10
Diarrhea 8
Stiffness/Spasticity 8

Show all 123 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 54
3 mg daily 27
50 mg daily 12
1.5 mg daily 7
4 mg daily 7
3.5 mg daily 6
1 mg daily 3
2 mg daily 3
2.5 mg daily 3
1 other daily 2

See all 32 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 133
Other 65
Side effects too severe 47
Doctor's advice 40
Expense 16
Personal research 11
Course of treatment ended 9
Change in health plan coverage 1
See all 258 patients who've stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
1 - 6 months 19
6 months - 1 year 16
1 - 2 years 22
2 - 5 years 34
5 - 10 years 49
10 years or more 9

Stopped taking Naltrexone

Duration Patients
Less than 1 month 37
1 - 6 months 84
6 months - 1 year 35
1 - 2 years 62
2 - 5 years 36
5 - 10 years 9
Adherence
Adherence Evaluations
Always 757
Usually 107
Sometimes 16
Never taken as prescribed 19
Burden
Burden Evaluations
Very hard to take 15
Somewhat hard to take 39
A little hard to take 114
Not at all hard to take 731
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 100
$25-49 444
< $25 238
Not specified 103

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Hydrocodone-Acetaminophen (Norco) 7
Pregabalin (Lyrica) 6
Gabapentin (Neurontin) 4
Prednisone (Deltasone) 4
Milnacipran (Savella) 3

Show all 39 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 2
Buprenorphine-Naloxone (Suboxone) 1
Dexamethasone (Decadron) 1
Fingolimod (Gilenya) 1
Hydrocodone-Acetaminophen (Norco) 1

Show all 10 treatments patients report switching to

Last updated:

77 patient evaluations for Naltrexone

Jul 2, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    Mild (Insomnia, occasional insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Mar 5, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2012 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication's given me some very un-expected increase in heat tolerance.
Cost: $50-99 monthly

Feb 9, 2009 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2008 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication is FDA approved for MS in "compounded" form only. If an MS patient can obtain a prescription for this medication (many neurologists won't consider writing a script for this), they'll need to have access to a "compounding" pharmacy. As with all medications, success rates appear to vary. Many people who I know that are using LDN have realized dramatic, if not astonishing symptomatic relief in addition to less disease activity. Some that I know tried it for a period of time without any noticible relief or change & thus stopped using it. Success rates have seemed to depend on dosage level, at least from my observations. Some using LDN notice change almost immediately at the lower dosage levels. Others, as noted above, realize no change at any dosage level. Personally, the symptom relief that I've noticed most is an increase in heat tolerance. As far as my overall success rate, I'd say this medication has done very well in slowing the progression. I've gone over 15 months without having an exacerbation or needing IV solu-medrol. 11 of those months have been since I began using LDN, & I'm not using highest dosage. Maintaining my mobility level & being essentially symptom free for this period of time is very unusual (& quite pleasant!) for me; especially over the last 3 yrs. Note: neurologists/MS specialists might recommend a dormant period of time between stopping a current medication (Beta-Seron, Avonex, etc.) & the beginning of LDN use.
Cost: $50-99 monthly

  • 4 helpful marks

Mar 21, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I am convinced LDN helps slightly but it not enough. 5 month without painkillers and only twice shortly om prednisolone should indicate some effect. Only I can't go on just now, my pains are too severe.
Cost: < $25 monthly

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for Alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 77 patient evaluations for Naltrexone