What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders. Naltrexone was FDA-approved in 1985 for the management of alcohol dependence and opioid dependence at 50mg doses.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple Sclerosis 459 348
Fibromyalgia 154 230
Fatigue 126 177
Pain 43 57
ALS (Amyotrophic Lateral Sclerosis) 39 37
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 34 93

Show all 167 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 37
Moderate 53
Mild 211
None 570

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 28
Nausea 17
Headaches 12
Insomnia 8
Stiffness/Spasticity 8
Diarrhea 7

Show all 117 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 47
3 mg daily 24
50 mg daily 12
1.5 mg daily 11
4 mg daily 11
2 mg daily 6
2.5 mg daily 3
3.5 mg daily 3
5 mg daily 3
0.25 mg daily 2

See all 24 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 130
Other 63
Side effects too severe 46
Doctor's advice 39
Expense 15
Personal research 12
Course of treatment ended 9
Change in health plan coverage 2
See all 250 patients who’ve stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
Less than 1 month 1
1 - 6 months 23
6 months - 1 year 12
1 - 2 years 19
2 - 5 years 34
5 - 10 years 43
10 years or more 6

Stopped taking Naltrexone

Duration Patients
Less than 1 month 34
1 - 6 months 84
6 months - 1 year 32
1 - 2 years 63
2 - 5 years 33
5 - 10 years 9
Adherence
Adherence Evaluations
Always 732
Usually 104
Sometimes 16
Never taken as prescribed 19
Burden
Burden Evaluations
Very hard to take 15
Somewhat hard to take 39
A little hard to take 114
Not at all hard to take 703
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 99
$25-49 425
< $25 236
Not specified 97

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Pregabalin (Lyrica) 6
Hydrocodone-Acetaminophen (Norco) 5
Gabapentin (Neurontin) 4
Prednisone (Deltasone) 4
Milnacipran (Savella) 3

Show all 38 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dexamethasone (Decadron) 1
Dimethyl fumarate (Tecfidera) 1
Fingolimod (Gilenya) 1
Hydrocodone-Acetaminophen (Norco) 1
Lamotrigine (Lamictal) 1

Show all 9 treatments patients report switching to

Last updated:

77 patient evaluations for Naltrexone

485 members have decided to share their profiles only with other members of PatientsLikeMe.

gummitarzan
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gummitarzan
Data Quality: 3 stars
  • Gender: M
  • Age: 70
Condition: Rheumatoid Arthritis (RA) 5 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See gummitarzan's full Naltrexone history

Mar 21, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I am convinced LDN helps slightly but it not enough. 5 month without painkillers and only twice shortly om prednisolone should indicate some effect. Only I can't go on just now, my pains are too severe.
Cost: < $25 monthly

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
slowrambler
Portrait default thumb
slowrambler
Sex: M
Data Quality: 2 stars
Relapse: Moderate
Sensation: Severe
Overall: Mild
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: severe
I am: b
I have:
MS

See slowrambler's full Naltrexone history

Mar 5, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Moderate (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2012 (Started Sep 01, 2008)

  • Effectiveness
    Major (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication's given me some very un-expected increase in heat tolerance.
Cost: $50-99 monthly

Feb 9, 2009 (Started Sep 01, 2008)

  • Effectiveness
    Major (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2008 (Started Sep 01, 2008)

  • Effectiveness
    Major (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication is FDA approved for MS in "compounded" form only. If an MS patient can obtain a prescription for this medication (many neurologists won't consider writing a script for this), they'll need to have access to a "compounding" pharmacy. As with all medications, success rates appear to vary. Many people who I know that are using LDN have realized dramatic, if not astonishing symptomatic relief in addition to less disease activity. Some that I know tried it for a period of time without any noticible relief or change & thus stopped using it. Success rates have seemed to depend on dosage level, at least from my observations. Some using LDN notice change almost immediately at the lower dosage levels. Others, as noted above, realize no change at any dosage level. Personally, the symptom relief that I've noticed most is an increase in heat tolerance. As far as my overall success rate, I'd say this medication has done very well in slowing the progression. I've gone over 15 months without having an exacerbation or needing IV solu-medrol. 11 of those months have been since I began using LDN, & I'm not using highest dosage. Maintaining my mobility level & being essentially symptom free for this period of time is very unusual (& quite pleasant!) for me; especially over the last 3 yrs. Note: neurologists/MS specialists might recommend a dormant period of time between stopping a current medication (Beta-Seron, Avonex, etc.) & the beginning of LDN use.
Cost: $50-99 monthly

  • 4 helpful marks
Alexjeremy
31100 thumb
Alexjeremy
Gender: M
Data Quality: 1 star
Depression: 2
Mania: 2
Emotional: 3
Anxiety: 3
Compulsion: 1
External Stress: Overwhelming
31 M
Function: Moderate
Distress: Moderate
I am: g
I have:
GAD

See Alexjeremy's full Naltrexone history

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for Alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 77 patient evaluations for Naltrexone