What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders. Naltrexone was FDA-approved in 1985 for the management of alcohol dependence and opioid dependence at 50mg doses.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple Sclerosis 458 347
Fibromyalgia 150 224
Fatigue 125 177
Pain 44 56
ALS (Amyotrophic Lateral Sclerosis) 39 37
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 34 93

Show all 165 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 37
Moderate 53
Mild 205
None 559

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 27
Nausea 17
Headaches 12
Insomnia 8
Stiffness/Spasticity 8
Diarrhea 7

Show all 116 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 54
3 mg daily 23
4 mg daily 11
50 mg daily 9
1.5 mg daily 7
3.5 mg daily 5
5 mg daily 4
1 capsule(s) daily 3
1 mg daily 3
2 mg daily 3

See all 28 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 126
Other 61
Side effects too severe 46
Doctor's advice 39
Expense 14
Personal research 11
Course of treatment ended 9
Change in health plan coverage 1
See all 245 patients who’ve stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
Less than 1 month 1
1 - 6 months 20
6 months - 1 year 16
1 - 2 years 21
2 - 5 years 27
5 - 10 years 50
10 years or more 9

Stopped taking Naltrexone

Duration Patients
Less than 1 month 32
1 - 6 months 85
6 months - 1 year 31
1 - 2 years 62
2 - 5 years 31
5 - 10 years 9
Adherence
Adherence Evaluations
Always 721
Usually 101
Sometimes 16
Never taken as prescribed 16
Burden
Burden Evaluations
Very hard to take 13
Somewhat hard to take 39
A little hard to take 114
Not at all hard to take 688
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 97
$25-49 417
< $25 234
Not specified 92

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Pregabalin (Lyrica) 6
Hydrocodone-Acetaminophen (Norco) 5
Prednisone (Deltasone) 4
Gabapentin (Neurontin) 3
Milnacipran (Savella) 3

Show all 36 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dexamethasone (Decadron) 1
Dimethyl fumarate (Tecfidera) 1
Fingolimod (Gilenya) 1
Hydrocodone-Acetaminophen (Norco) 1
Lamotrigine (Lamictal) 1

Show all 9 treatments patients report switching to

Last updated:

77 patient evaluations for Naltrexone

477 members have decided to share their profiles only with other members of PatientsLikeMe.

gummitarzan
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gummitarzan
Data Quality: 3 stars
  • Gender: M
  • Age: 69
Condition: Rheumatoid Arthritis (RA) 5 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See gummitarzan's full Naltrexone history

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
Alexjeremy
31100 thumb
Alexjeremy
Gender: M
Data Quality: 1 star
Depression: 2
Mania: 2
Emotional: 3
Anxiety: 3
Compulsion: 1
External Stress: Overwhelming
31 M
Function: Moderate
Distress: Moderate
I am: g
I have:
GAD

See Alexjeremy's full Naltrexone history

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for Alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
kcj1963
43746 thumb
kcj1963
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Moderate
Cognition: moderate
Vision: mild
Speech: moderate
Swallowing: moderate
Upper limb: moderate
Walking: moderate
I am: n
I have:
MS

See kcj1963's full Naltrexone history

Mar 24, 2016 (Started Apr 15, 2015)

  • Effectiveness
    Can’t tell (for Multiple Sclerosis)
  • Side effects
    Mild (Dehydration, Headaches in morning)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily
Advice & Tips: low toxicity, defintintely helps with depression and nerve pain
Cost: $25-49 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 77 patient evaluations for Naltrexone