What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 465 361
Fibromyalgia 169 251
Fatigue 133 190
Pain 49 62
Amyotrophic lateral sclerosis 39 38
Myalgic encephalomyelitis/chronic fatigue syndrome 38 94

Show all 164 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 40
Moderate 57
Mild 221
None 613

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 31
Nausea 17
Headaches 12
Insomnia 11
Diarrhea 8
Stiffness/spasticity 8

Show all 113 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 79
3 mg daily 42
1.5 mg daily 12
50 mg daily 12
4 mg daily 11
3.5 mg daily 6
1 mg daily 5
5 mg daily 5
2 mg daily 4
1 capsule(s) daily 3

See all 29 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 141
Other 68
Side effects too severe 47
Doctor's advice 42
Expense 19
Personal research 11
Course of treatment ended 9
Change in health plan coverage 2
See all 272 patients who've stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
Less than 1 month 2
1 - 6 months 7
6 months - 1 year 22
1 - 2 years 19
2 - 5 years 47
5 - 10 years 73
10 years or more 29

Stopped taking Naltrexone

Duration Patients
Less than 1 month 39
1 - 6 months 91
6 months - 1 year 35
1 - 2 years 65
2 - 5 years 37
5 - 10 years 10
Adherence
Adherence Evaluations
Always 785
Usually 110
Sometimes 16
Never taken as prescribed 20
Burden
Burden Evaluations
Very hard to take 15
Somewhat hard to take 42
A little hard to take 114
Not at all hard to take 760
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 8
$50-99 106
$25-49 459
< $25 240
Not specified 110

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Gabapentin (Neurontin) 7
Hydrocodone-Acetaminophen (Norco) 7
Pregabalin (Lyrica) 7
Tramadol (Ultram) 6
Duloxetine (Cymbalta) 5

Show all 41 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 2
Azathioprine (Imuran) 1
Buprenorphine-Naloxone (Suboxone) 1
Dexamethasone (Decadron) 1
Fingolimod (Gilenya) 1

Show all 12 treatments patients report switching to

Last updated:

80 patient evaluations for Naltrexone

Jul 2, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    Mild (insomnia, occasional insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Mar 5, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2012 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication's given me some very un-expected increase in heat tolerance.
Cost: $50-99 monthly

Feb 9, 2009 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2008 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication is FDA approved for MS in "compounded" form only. If an MS patient can obtain a prescription for this medication (many neurologists won't consider writing a script for this), they'll need to have access to a "compounding" pharmacy. As with all medications, success rates appear to vary. Many people who I know that are using LDN have realized dramatic, if not astonishing symptomatic relief in addition to less disease activity. Some that I know tried it for a period of time without any noticible relief or change & thus stopped using it. Success rates have seemed to depend on dosage level, at least from my observations. Some using LDN notice change almost immediately at the lower dosage levels. Others, as noted above, realize no change at any dosage level. Personally, the symptom relief that I've noticed most is an increase in heat tolerance. As far as my overall success rate, I'd say this medication has done very well in slowing the progression. I've gone over 15 months without having an exacerbation or needing IV solu-medrol. 11 of those months have been since I began using LDN, & I'm not using highest dosage. Maintaining my mobility level & being essentially symptom free for this period of time is very unusual (& quite pleasant!) for me; especially over the last 3 yrs. Note: neurologists/MS specialists might recommend a dormant period of time between stopping a current medication (Beta-Seron, Avonex, etc.) & the beginning of LDN use.
Cost: $50-99 monthly

  • 4 helpful marks

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Mar 24, 2016 (Started Apr 15, 2015)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    Mild (dehydration, headaches in morning)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily
Advice & Tips: low toxicity, defintintely helps with depression and nerve pain
Cost: $25-49 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 80 patient evaluations for Naltrexone