What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 464 362
Fibromyalgia 172 255
Fatigue 135 191
Pain 50 63
Amyotrophic lateral sclerosis 39 38
Myalgic encephalomyelitis/chronic fatigue syndrome 39 95

Show all 162 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 41
Moderate 58
Mild 223
None 619

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 32
Nausea 17
Headaches 13
Insomnia 12
Diarrhea 8
Stiffness/spasticity 8

Show all 109 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 67
3 mg daily 45
1.5 mg daily 12
4 mg daily 11
50 mg daily 9
3.5 mg daily 6
1 mg daily 5
1 capsule(s) daily 3
2 mg daily 3
5 mg daily 3

See all 31 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 142
Other 68
Side effects too severe 48
Doctor's advice 43
Expense 19
Personal research 11
Course of treatment ended 9
Change in health plan coverage 2
See all 273 patients who've stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
1 - 6 months 10
6 months - 1 year 16
1 - 2 years 24
2 - 5 years 38
5 - 10 years 73
10 years or more 27

Stopped taking Naltrexone

Duration Patients
Less than 1 month 39
1 - 6 months 90
6 months - 1 year 35
1 - 2 years 65
2 - 5 years 39
5 - 10 years 10
Adherence
Adherence Evaluations
Always 794
Usually 111
Sometimes 16
Never taken as prescribed 20
Burden
Burden Evaluations
Very hard to take 15
Somewhat hard to take 42
A little hard to take 116
Not at all hard to take 768
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 9
$50-99 106
$25-49 465
< $25 240
Not specified 113

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Gabapentin (Neurontin) 7
Hydrocodone-Acetaminophen (Norco) 7
Pregabalin (Lyrica) 7
Tramadol (Ultram) 6
Duloxetine (Cymbalta) 5

Show all 40 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 2
Azathioprine (Imuran) 1
Buprenorphine-Naloxone (Suboxone) 1
Dexamethasone (Decadron) 1
Fingolimod (Gilenya) 1

Show all 12 treatments patients report switching to

Last updated:

80 patient evaluations for Naltrexone

Jul 2, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    Mild (insomnia, occasional insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Mar 5, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2012 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication's given me some very un-expected increase in heat tolerance.
Cost: $50-99 monthly

Feb 9, 2009 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2008 (Started Sep 01, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication is FDA approved for MS in "compounded" form only. If an MS patient can obtain a prescription for this medication (many neurologists won't consider writing a script for this), they'll need to have access to a "compounding" pharmacy. As with all medications, success rates appear to vary. Many people who I know that are using LDN have realized dramatic, if not astonishing symptomatic relief in addition to less disease activity. Some that I know tried it for a period of time without any noticible relief or change & thus stopped using it. Success rates have seemed to depend on dosage level, at least from my observations. Some using LDN notice change almost immediately at the lower dosage levels. Others, as noted above, realize no change at any dosage level. Personally, the symptom relief that I've noticed most is an increase in heat tolerance. As far as my overall success rate, I'd say this medication has done very well in slowing the progression. I've gone over 15 months without having an exacerbation or needing IV solu-medrol. 11 of those months have been since I began using LDN, & I'm not using highest dosage. Maintaining my mobility level & being essentially symptom free for this period of time is very unusual (& quite pleasant!) for me; especially over the last 3 yrs. Note: neurologists/MS specialists might recommend a dormant period of time between stopping a current medication (Beta-Seron, Avonex, etc.) & the beginning of LDN use.
Cost: $50-99 monthly

  • 4 helpful marks

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Mar 24, 2016 (Started Apr 15, 2015)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    Mild (dehydration, headaches in morning)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily
Advice & Tips: low toxicity, defintintely helps with depression and nerve pain
Cost: $25-49 monthly

  • 2 helpful marks
Last updated:
Showing 3 of 80 patient evaluations for Naltrexone