What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 464 360
Fibromyalgia 169 252
Fatigue 133 190
Pain 49 62
Amyotrophic lateral sclerosis 39 38
Myalgic encephalomyelitis/chronic fatigue syndrome 38 94

Show all 163 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 40
Moderate 57
Mild 221
None 611

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 31
Nausea 17
Headaches 12
Insomnia 11
Diarrhea 8
Stiffness/spasticity 8

Show all 127 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 80
3 mg daily 43
50 mg daily 16
4 mg daily 12
1.5 mg daily 9
3.5 mg daily 6
5 mg daily 6
1 mg daily 5
2 mg daily 5
1 capsule(s) daily 2

See all 31 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 140
Other 68
Side effects too severe 47
Doctor's advice 42
Expense 19
Personal research 11
Course of treatment ended 9
Change in health plan coverage 2
See all 271 patients who've stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
1 - 6 months 12
6 months - 1 year 24
1 - 2 years 23
2 - 5 years 44
5 - 10 years 79
10 years or more 24

Stopped taking Naltrexone

Duration Patients
Less than 1 month 39
1 - 6 months 90
6 months - 1 year 35
1 - 2 years 65
2 - 5 years 37
5 - 10 years 10
Adherence
Adherence Evaluations
Always 784
Usually 109
Sometimes 16
Never taken as prescribed 20
Burden
Burden Evaluations
Very hard to take 15
Somewhat hard to take 41
A little hard to take 114
Not at all hard to take 759
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 8
$50-99 105
$25-49 459
< $25 240
Not specified 109

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Hydrocodone-Acetaminophen (Norco) 7
Pregabalin (Lyrica) 7
Gabapentin (Neurontin) 6
Tramadol (Ultram) 6
Duloxetine (Cymbalta) 5

Show all 40 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 2
Azathioprine (Imuran) 1
Buprenorphine-Naloxone (Suboxone) 1
Dexamethasone (Decadron) 1
Fingolimod (Gilenya) 1

Show all 12 treatments patients report switching to

Last updated:

80 patient evaluations for Naltrexone

Jan 25, 2018 (Started Nov 22, 2017)

  • Effectiveness
    Moderate (for alcohol cravings)
  • Side effects
    Moderate (injection site pain)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 380 mg Monthly
Advice & Tips: The injection is large and somewhat painful in your hip for a few days. If you massage the area in the first few days, the lump will dissipate and the pain will stop.

Nov 24, 2017 (Started Nov 22, 2017)

  • Effectiveness
    Slight (for alcohol cravings)
  • Side effects
    Mild (injection site pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 380 mg Monthly

  • 0 helpful marks

Dec 15, 2017 (Started Oct 13, 2017)

  • Effectiveness
    None (for complex regional pain syndrome type I)
  • Side effects
    Severe (vivid dreams)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Aug 17, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3.3 mg Daily
Advice & Tips: There is really no need to continue, because is so hard to get a prescription and it does not help me much anyway.
Cost: < $25 monthly

Mar 21, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I am convinced LDN helps slightly but it not enough. 5 month without painkillers and only twice shortly om prednisolone should indicate some effect. Only I can't go on just now, my pains are too severe.
Cost: < $25 monthly

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 80 patient evaluations for Naltrexone