What is Naltrexone?

Category: Prescription Drugs

Most popular types: Low Dose Naltrexone (LDN) ReVia Vivitrol

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Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 464 362
Fibromyalgia 173 256
Fatigue 135 191
Pain 50 63
Amyotrophic lateral sclerosis 39 38
Myalgic encephalomyelitis/chronic fatigue syndrome 39 95

Show all 162 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 41
Moderate 58
Mild 224
None 620

Commonly reported side effects and conditions associated with Naltrexone

Side effect Patients
Vivid dreams 32
Nausea 18
Headaches 13
Insomnia 12
Diarrhea 8
Stiffness/spasticity 8

Show all 105 reported side effects

Dosages

Based on patients currently taking Naltrexone

Dosage Patients
4.5 mg daily 68
3 mg daily 41
1.5 mg daily 10
4 mg daily 10
50 mg daily 10
3.5 mg daily 7
1 capsule(s) daily 3
1 mg daily 3
5 mg daily 3
2 mg daily 2

See all 30 dosages

Why patients stopped taking Naltrexone

Multiple reasons could be selected

Reason Patients
Did not seem to work 143
Other 68
Side effects too severe 48
Doctor's advice 43
Expense 19
Personal research 11
Course of treatment ended 9
Change in health plan coverage 2
See all 274 patients who've stopped taking Naltrexone

Duration

Currently taking Naltrexone

Duration Patients
1 - 6 months 9
6 months - 1 year 15
1 - 2 years 24
2 - 5 years 37
5 - 10 years 69
10 years or more 25

Stopped taking Naltrexone

Duration Patients
Less than 1 month 39
1 - 6 months 90
6 months - 1 year 36
1 - 2 years 65
2 - 5 years 39
5 - 10 years 10
Adherence
Adherence Evaluations
Always 796
Usually 111
Sometimes 16
Never taken as prescribed 20
Burden
Burden Evaluations
Very hard to take 15
Somewhat hard to take 42
A little hard to take 116
Not at all hard to take 770
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 9
$50-99 106
$25-49 466
< $25 241
Not specified 113

What people switch to and from

Patients started taking Naltrexone after stopping:

Treatment Patients
Gabapentin (Neurontin) 7
Hydrocodone-Acetaminophen (Norco) 7
Pregabalin (Lyrica) 7
Tramadol (Ultram) 6
Duloxetine (Cymbalta) 5

Show all 39 treatments patients report switching from

Patients stopped taking Naltrexone and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 2
Azathioprine (Imuran) 1
Buprenorphine-Naloxone (Suboxone) 1
Dexamethasone (Decadron) 1
Fingolimod (Gilenya) 1

Show all 12 treatments patients report switching to

Last updated:

80 patient evaluations for Naltrexone

Jan 25, 2018 (Started Nov 22, 2017)

  • Effectiveness
    Moderate (for alcohol cravings)
  • Side effects
    Moderate (injection site pain)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 380 mg Monthly
Advice & Tips: The injection is large and somewhat painful in your hip for a few days. If you massage the area in the first few days, the lump will dissipate and the pain will stop.

Nov 24, 2017 (Started Nov 22, 2017)

  • Effectiveness
    Slight (for alcohol cravings)
  • Side effects
    Mild (injection site pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 380 mg Monthly

  • 0 helpful marks

Dec 15, 2017 (Started Oct 13, 2017)

  • Effectiveness
    None (for complex regional pain syndrome type I)
  • Side effects
    Severe (vivid dreams)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Aug 17, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3.3 mg Daily
Advice & Tips: There is really no need to continue, because is so hard to get a prescription and it does not help me much anyway.
Cost: < $25 monthly

Mar 21, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I am convinced LDN helps slightly but it not enough. 5 month without painkillers and only twice shortly om prednisolone should indicate some effect. Only I can't go on just now, my pains are too severe.
Cost: < $25 monthly

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 80 patient evaluations for Naltrexone