What is Diphenoxylate and Atropine?

Category: Prescription Drugs

Most popular types: Lomotil Lonox Imodium A-D New Formula

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Diphenoxylate and atropine is used to control diarrhea. Diphenoxylate is an opioid agonist used for the treatment of diarrhea that acts by slowing intestinal contractions. Because opiates can be habit forming, atropine is added, which can make the user feel nausea or weak if too much is taken.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Diarrhea 33 19
Chronic diarrhea 26 10
Bowel irritability 21 12
Irritable bowel syndrome 6 2
Bowel incontinence 3 0
Short bowel syndrome 3 0

Show all 13 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 2
Moderate 4
Mild 8
None 20

Commonly reported side effects and conditions associated with Diphenoxylate and Atropine

Side effect Patients
Constipation 7
Drowsiness 2
Alternating constipation and diarrhea 1
Bowel irritability 1
Cramps in back 1
Dizziness 1

Show all 12 reported side effects

Dosages

Based on patients currently taking Diphenoxylate and Atropine

Dosage Patients
0.025-2.5 mg three times daily 2
2 x 0.025-2.5 mg four times daily 2
3 x 0.025 mg-2.5 mg daily 2
2.5mg as needed 2
0.025-2.5 mg twice daily 1
3 x 0.025-2.5 mg daily 1
2 x 0.025-2.5 mg twice daily 1
0.025 mg-2.5 mg twice daily 1
2 x 0.025 mg-2.5 mg daily 1
2.5 mg four times daily 1

See all 14 dosages

Why patients stopped taking Diphenoxylate and Atropine

Multiple reasons could be selected

Reason Patients
Other 9
Course of treatment ended 6
Doctor's advice 4
Did not seem to work 2
Side effects too severe 2
Change in health plan coverage 1
Personal research 1
See all 23 patients who've stopped taking Diphenoxylate and Atropine

Duration

Currently taking Diphenoxylate and Atropine

Duration Patients
1 - 6 months 1
6 months - 1 year 1
1 - 2 years 2
2 - 5 years 3
5 - 10 years 3
10 years or more 8

Stopped taking Diphenoxylate and Atropine

Duration Patients
Less than 1 month 6
1 - 6 months 2
6 months - 1 year 5
1 - 2 years 5
2 - 5 years 3
5 - 10 years 2
Adherence
Adherence Evaluations
Always 23
Usually 5
Sometimes 5
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 3
A little hard to take 3
Not at all hard to take 27
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 0
$50-99 0
$25-49 1
< $25 14
Not specified 19

What people switch to and from

Patients started taking Diphenoxylate and Atropine after stopping:

Treatment Patients
Glycopyrrolate (Robinul) 1
Loperamide (Imodium) 1
Loperamide-Simethicone (Imodium Multi-Symptom Relief) 1

Patients stopped taking Diphenoxylate and Atropine and switched to:

Treatment Patients
Dicyclomine (Bentyl) 1
Opium (Tincture of opium) 1
Last updated:

1 patient evaluation for Diphenoxylate and Atropine

Oct 22, 2008 (Started Oct 22, 2008)

  • Effectiveness
    Major (for Increase effect of another treatment)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 1 of 1 patient evaluation for Diphenoxylate and Atropine