What is Tizanidine?

Category: Prescription Drugs

Most popular types: Zanaflex Sirdalud Sirdalud Retard Show all

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Tizanidine hydrochloride is a skeletal muscle relaxant used for treatment of muscle spasticity. It may also be used for tension headaches, low back pain, and trigeminal neuralgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Stiffness/spasticity 841 316
Muscle spasms 637 254
Fibromyalgia 330 120
Muscle pain 88 32
Pain 83 45
Muscle spasms in neck and shoulders 57 16

Show all 153 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 68
Moderate 164
Mild 180
None 259

Commonly reported side effects and conditions associated with Tizanidine

Side effect Patients
Sleepiness 75
Drowsiness 61
Dry mouth 46
Fatigue 28
Excessive daytime sleepiness (somnolence) 25
Dry eyes 17

Show all 128 reported side effects

Dosages

Based on patients currently taking Tizanidine

Dosage Patients
4 mg daily 57
2 mg daily 27
8 mg daily 26
4 mg three times daily 26
4 mg twice daily 23
4mg as needed 21
12 mg daily 19
2 mg three times daily 17
8 mg three times daily 11
16 mg daily 8

See all 35 dosages

Why patients stopped taking Tizanidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 149
Side effects too severe 84
Doctor's advice 75
Other 74
Course of treatment ended 19
Personal research 17
Expense 12
Change in health plan coverage 8
See all 362 patients who've stopped taking Tizanidine

Duration

Currently taking Tizanidine

Duration Patients
Less than 1 month 2
1 - 6 months 24
6 months - 1 year 24
1 - 2 years 47
2 - 5 years 82
5 - 10 years 76
10 years or more 40

Stopped taking Tizanidine

Duration Patients
Less than 1 month 55
1 - 6 months 100
6 months - 1 year 55
1 - 2 years 59
2 - 5 years 58
5 - 10 years 27
10 years or more 10
Adherence
Adherence Evaluations
Always 474
Usually 118
Sometimes 56
Never taken as prescribed 23
Burden
Burden Evaluations
Very hard to take 31
Somewhat hard to take 35
A little hard to take 92
Not at all hard to take 513
Cost per month
Cost per month Evaluations
$200+ 3
$100-199 0
$50-99 16
$25-49 43
< $25 369
Not specified 240

What people switch to and from

Patients started taking Tizanidine after stopping:

Treatment Patients
Cyclobenzaprine (Flexeril) 47
Baclofen (Mylan-Baclofen) 29
Carisoprodol (Soma) 11
Diazepam (Valium) 3
Hydrocodone-Acetaminophen (Norco) 3

Show all 29 treatments patients report switching from

Patients stopped taking Tizanidine and switched to:

Treatment Patients
Baclofen (Mylan-Baclofen) 23
Cyclobenzaprine (Flexeril) 7
Clonazepam (Klonopin) 3
Baclofen intrathecal pump (Lioresal) 2
Diazepam (Valium) 2

Show all 18 treatments patients report switching to

Last updated:

86 patient evaluations for Tizanidine

Jul 29, 2017 (Started Mar 06, 2014)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 24 mg Daily
Advice & Tips: this dosage and timing schedule works well for me.
Cost: < $25 monthly

Nov 30, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 24 mg Daily
Advice & Tips: I increased the dosage to 6 mg four times a day, because of increased left leg/foot spasticity in the evening.
Cost: < $25 monthly

Mar 25, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: Still effective for relief of spasticity and I usually bypass the sleepiness by spacing doses at 4 hour intervals.
Cost: < $25 monthly

Sep 21, 2015 (Started Mar 06, 2014)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: it's very effective for relief of spasticity, unfortunately it puts me into a deep sleep.
Cost: < $25 monthly

Oct 8, 2014 (Started Mar 06, 2014)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12 mg Daily
Advice & Tips: none, i sleep as needed.
Cost: < $25 monthly

  • 0 helpful marks

Jul 2, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (muscle fatigue, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Mar 5, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (muscle fatigue, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Sep 7, 2012 (Started Sep 10, 1999)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Feb 9, 2009 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Sep 7, 2008 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Side effects
    Mild (muscle fatigue, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: This medication served me very well for several yrs. after I'd exhausted the use of Baclofen, which had become totally ineffective for me. This medication is not instant in terms of effectiveness. I had to "wean off" of the Baclofen & "ramp up" the dosage of Zanaflex & maintain a consistent level of this medication (in my bloodstream) before it became truly effective. After it became ineffective singularly, I began using it in combination with Keppra & I'm still realizing positive results using this regimen. I do experience some minor muscle fatigue & occasional dry mouth while using Zanaflex, however nothing close in terems of negative side effects as compared to Baclofen.
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

  • 0 helpful marks

Aug 30, 2016 (Started Jul 15, 2013)

  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Effectiveness
    Moderate (for neck pain)
  • Side effects
    Mild (drowsiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 86 patient evaluations for Tizanidine