What is Tizanidine?

Category: Prescription Drugs

Most popular types: Zanaflex Sirdalud Sirdalud Retard Show all

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Tizanidine hydrochloride is a skeletal muscle relaxant used for treatment of muscle spasticity. It may also be used for tension headaches, low back pain, and trigeminal neuralgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Stiffness/Spasticity 831 306
Muscle spasms 647 245
Fibromyalgia 317 111
Muscle pain 86 30
Pain 82 44
Muscle spasms in neck and shoulders 56 12

Show all 160 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 63
Moderate 160
Mild 171
None 254

Commonly reported side effects and conditions associated with Tizanidine

Side effect Patients
Sleepiness 73
Drowsiness 55
Dry mouth 46
Fatigue 26
Excessive daytime sleepiness (somnolence) 21
Dry eyes 17

Show all 121 reported side effects

Dosages

Based on patients currently taking Tizanidine

Dosage Patients
4 mg daily 56
8 mg daily 29
2 mg daily 23
4 mg three times daily 21
4mg as needed 19
4 mg twice daily 18
12 mg daily 18
2 mg three times daily 16
6 mg daily 12
2mg as needed 12

See all 39 dosages

Why patients stopped taking Tizanidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 150
Side effects too severe 86
Doctor's advice 72
Other 72
Course of treatment ended 19
Personal research 16
Expense 12
Change in health plan coverage 9
See all 357 patients who’ve stopped taking Tizanidine

Duration

Currently taking Tizanidine

Duration Patients
Less than 1 month 4
1 - 6 months 24
6 months - 1 year 34
1 - 2 years 45
2 - 5 years 74
5 - 10 years 76
10 years or more 35

Stopped taking Tizanidine

Duration Patients
Less than 1 month 54
1 - 6 months 99
6 months - 1 year 55
1 - 2 years 58
2 - 5 years 56
5 - 10 years 27
10 years or more 10
Adherence
Adherence Evaluations
Always 450
Usually 118
Sometimes 58
Never taken as prescribed 22
Burden
Burden Evaluations
Very hard to take 31
Somewhat hard to take 34
A little hard to take 93
Not at all hard to take 490
Cost per month
Cost per month Evaluations
$200+ 3
$100-199 0
$50-99 15
$25-49 42
< $25 358
Not specified 230

What people switch to and from

Patients started taking Tizanidine after stopping:

Treatment Patients
Cyclobenzaprine (Flexeril) 38
Baclofen (Mylan-Baclofen) 25
Carisoprodol (Soma) 11
Diazepam (Valium) 3
Hydrocodone-Acetaminophen (Norco) 3

Show all 25 treatments patients report switching from

Patients stopped taking Tizanidine and switched to:

Treatment Patients
Baclofen (Mylan-Baclofen) 21
Cyclobenzaprine (Flexeril) 7
Diazepam (Valium) 3
Baclofen intrathecal pump (Lioresal) 2
Clonazepam (Klonopin) 2

Show all 17 treatments patients report switching to

Last updated:

86 patient evaluations for Tizanidine

496 members have decided to share their profiles only with other members of PatientsLikeMe.

slowrambler
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slowrambler
Sex: M
Data Quality: 2 stars
Relapse: Moderate
Sensation: Severe
Overall: Mild
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: severe
I am: b
I have:
MS

See slowrambler's full Tizanidine history

Mar 5, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Muscle fatigue, Dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Sep 7, 2012 (Started Sep 10, 1999)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Feb 9, 2009 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Sep 7, 2008 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Side effects
    Mild (Muscle fatigue, Dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: This medication served me very well for several yrs. after I'd exhausted the use of Baclofen, which had become totally ineffective for me. This medication is not instant in terms of effectiveness. I had to "wean off" of the Baclofen & "ramp up" the dosage of Zanaflex & maintain a consistent level of this medication (in my bloodstream) before it became truly effective. After it became ineffective singularly, I began using it in combination with Keppra & I'm still realizing positive results using this regimen. I do experience some minor muscle fatigue & occasional dry mouth while using Zanaflex, however nothing close in terems of negative side effects as compared to Baclofen.
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

  • 0 helpful marks
thjuland
647 thumb
thjuland
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: none
Speech: none
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: n
I have:
MS

See thjuland's full Tizanidine history

Nov 30, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 24 mg Daily
Advice & Tips: I increased the dosage to 6 mg four times a day, because of increased left leg/foot spasticity in the evening.
Cost: < $25 monthly

Mar 25, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: Still effective for relief of spasticity and I usually bypass the sleepiness by spacing doses at 4 hour intervals.
Cost: < $25 monthly

Sep 21, 2015 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: it's very effective for relief of spasticity, unfortunately it puts me into a deep sleep.
Cost: < $25 monthly

Oct 8, 2014 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12 mg Daily
Advice & Tips: none, i sleep as needed.
Cost: < $25 monthly

  • 0 helpful marks
Srs2388
85822 thumb
Srs2388
Data Quality: 1 star
  • Gender: M
  • Age: 29y
  • Duration: ? yrs
Quality of life:
  • Mental: Severe
  • Physical: Severe
2 seizures
15 weeks ago
I am: vb
I have:
Epilepsy

See Srs2388's full Tizanidine history

Apr 13, 2016 (Started Apr 15, 2016)

  • Effectiveness
    Slight (for Stiffness/Spasticity)
  • Side effects
    Severe (Dry mouth, Drowsiness)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 4 mg Four times daily
Advice & Tips: If you have to be alert, avoid it. Keep a drink close.

  • 0 helpful marks
Last updated:
Showing 3 of 86 patient evaluations for Tizanidine