What is Tizanidine?

Category: Prescription Drugs

Most popular types: Zanaflex Sirdalud Sirdalud Retard Show all

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Tizanidine hydrochloride is a skeletal muscle relaxant used for treatment of muscle spasticity. It may also be used for tension headaches, low back pain, and trigeminal neuralgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Stiffness/Spasticity 825 300
Muscle spasms 633 238
Fibromyalgia 313 108
Muscle pain 86 30
Pain 82 44
Muscle spasms in neck and shoulders 56 12

Show all 159 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 62
Moderate 157
Mild 169
None 248

Commonly reported side effects and conditions associated with Tizanidine

Side effect Patients
Sleepiness 73
Drowsiness 53
Dry mouth 46
Fatigue 25
Excessive daytime sleepiness (somnolence) 20
Dry eyes 17

Show all 120 reported side effects

Dosages

Based on patients currently taking Tizanidine

Dosage Patients
4 mg daily 56
8 mg daily 27
2 mg daily 20
4mg as needed 20
12 mg daily 19
4 mg three times daily 19
2 mg three times daily 14
4 mg twice daily 14
6 mg daily 9
2mg as needed 8

See all 37 dosages

Why patients stopped taking Tizanidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 146
Side effects too severe 85
Other 71
Doctor's advice 69
Course of treatment ended 19
Personal research 15
Expense 12
Change in health plan coverage 9
See all 350 patients who’ve stopped taking Tizanidine

Duration

Currently taking Tizanidine

Duration Patients
Less than 1 month 1
1 - 6 months 22
6 months - 1 year 30
1 - 2 years 42
2 - 5 years 72
5 - 10 years 71
10 years or more 32

Stopped taking Tizanidine

Duration Patients
Less than 1 month 53
1 - 6 months 97
6 months - 1 year 54
1 - 2 years 57
2 - 5 years 55
5 - 10 years 26
10 years or more 10
Adherence
Adherence Evaluations
Always 440
Usually 117
Sometimes 57
Never taken as prescribed 22
Burden
Burden Evaluations
Very hard to take 31
Somewhat hard to take 33
A little hard to take 93
Not at all hard to take 479
Cost per month
Cost per month Evaluations
$200+ 3
$100-199 0
$50-99 15
$25-49 41
< $25 352
Not specified 225

What people switch to and from

Patients started taking Tizanidine after stopping:

Treatment Patients
Cyclobenzaprine (Flexeril) 32
Baclofen (Mylan-Baclofen) 25
Carisoprodol (Soma) 11
Diazepam (Valium) 3
Hydrocodone-Acetaminophen (Norco) 3

Show all 23 treatments patients report switching from

Patients stopped taking Tizanidine and switched to:

Treatment Patients
Baclofen (Mylan-Baclofen) 17
Cyclobenzaprine (Flexeril) 6
Baclofen Intrathecal pump (Lioresal) 2
Clonazepam (Klonopin) 2
Diazepam (Valium) 2

Show all 17 treatments patients report switching to

Last updated:

86 patient evaluations for Tizanidine

486 members have decided to share their profiles only with other members of PatientsLikeMe.

slowrambler
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slowrambler
Sex: M
Data Quality: 2 stars
Relapse: Moderate
Sensation: Severe
Overall: Mild
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: severe
I am: vg
I have:
MS

See slowrambler's full Tizanidine history

Mar 5, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Muscle fatigue, Dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Sep 7, 2012 (Started Sep 10, 1999)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Feb 9, 2009 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

Sep 7, 2008 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for Stiffness/Spasticity)
  • Side effects
    Mild (Muscle fatigue, Dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: This medication served me very well for several yrs. after I'd exhausted the use of Baclofen, which had become totally ineffective for me. This medication is not instant in terms of effectiveness. I had to "wean off" of the Baclofen & "ramp up" the dosage of Zanaflex & maintain a consistent level of this medication (in my bloodstream) before it became truly effective. After it became ineffective singularly, I began using it in combination with Keppra & I'm still realizing positive results using this regimen. I do experience some minor muscle fatigue & occasional dry mouth while using Zanaflex, however nothing close in terems of negative side effects as compared to Baclofen.
Cost: < $25 monthly
Side effects: Dry mouth, Muscle fatigue

  • 0 helpful marks
thjuland
647 thumb
thjuland
Sex: M
Data Quality: 3 stars
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: none
Speech: none
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: n
I have:
MS

See thjuland's full Tizanidine history

Nov 30, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 24 mg Daily
Advice & Tips: I increased the dosage to 6 mg four times a day, because of increased left leg/foot spasticity in the evening.
Cost: < $25 monthly

Mar 25, 2016 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: Still effective for relief of spasticity and I usually bypass the sleepiness by spacing doses at 4 hour intervals.
Cost: < $25 monthly

Sep 21, 2015 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mg Daily
Advice & Tips: it's very effective for relief of spasticity, unfortunately it puts me into a deep sleep.
Cost: < $25 monthly

Oct 8, 2014 (Started Mar 06, 2014)

  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Side effects
    Mild (Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12 mg Daily
Advice & Tips: none, i sleep as needed.
Cost: < $25 monthly

  • 0 helpful marks
Srs2388
85822 thumb
Srs2388
Data Quality: 1 star
  • Gender: M
  • Age: 29y
  • Duration: ? yrs
Quality of life:
  • Mental: Severe
  • Physical: Severe
2 seizures
10 weeks ago
I am: vb
I have:
Epilepsy

See Srs2388's full Tizanidine history

Apr 13, 2016 (Started Apr 15, 2016)

  • Effectiveness
    Slight (for Stiffness/Spasticity)
  • Side effects
    Severe (Dry mouth, Drowsiness)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 4 mg Four times daily
Advice & Tips: If you have to be alert, avoid it. Keep a drink close.

  • 0 helpful marks
Last updated:
Showing 3 of 86 patient evaluations for Tizanidine