What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Simply Sleep Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 198 93
Allergies 185 66
Food allergy 55 27
Anaphylaxis 26 15
Itching 25 10

Show all 137 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 18
Moderate 59
Mild 74
None 119

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients
Drowsiness 29
Sleepiness 21
Dry mouth 12
Excessive daytime sleepiness (somnolence) 8
Groggy in morning 8
Brain fog 5

Show all 60 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients
25mg as needed 23
2 25mg as needed 20
50 mg daily 19
25 mg daily 16
50mg as needed 8
100 mg daily 7
25 mg twice daily 3
50 mg every other week 2
12.5 mg daily 2
50 mg twice daily 2

See all 32 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients
Other 63
Did not seem to work 47
Course of treatment ended 34
Doctor's advice 27
Side effects too severe 20
Personal research 11
Expense 4
Change in health plan coverage 1
See all 182 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients
Less than 1 month 1
1 - 6 months 10
6 months - 1 year 5
1 - 2 years 11
2 - 5 years 25
5 - 10 years 39
10 years or more 36

Stopped taking Diphenhydramine

Duration Patients
Less than 1 month 60
1 - 6 months 37
6 months - 1 year 25
1 - 2 years 16
2 - 5 years 21
5 - 10 years 8
10 years or more 18
Adherence
Adherence Evaluations
Always 151
Usually 70
Sometimes 37
Never taken as prescribed 12
Burden
Burden Evaluations
Very hard to take 3
Somewhat hard to take 17
A little hard to take 35
Not at all hard to take 215
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 0
$50-99 1
$25-49 7
< $25 141
Not specified 120

What people switch to and from

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients
Hydroxyzine (Vistaril) 4
Trazodone (Desyrel) 1
Last updated:

23 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for allergic contact dermatitis)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Sep 16, 2016 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for insomnia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 23 patient evaluations for Diphenhydramine