What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Simply Sleep Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 192 91
Allergies 183 65
Food allergy 53 26
Anaphylaxis 25 14
Itching 24 10

Show all 134 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 17
Moderate 58
Mild 73
None 118

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients
Drowsiness 29
Sleepiness 21
Dry mouth 12
Excessive daytime sleepiness (somnolence) 8
Groggy in morning 8
Brain fog 5

Show all 59 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients
25mg as needed 24
50 mg daily 19
25 mg daily 16
2 25mg as needed 16
100 mg daily 7
50mg as needed 7
25 mg twice daily 5
50 mg twice daily 3
50 mg every other week 2
75 mg daily 2

See all 32 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients
Other 60
Did not seem to work 47
Course of treatment ended 34
Doctor's advice 27
Side effects too severe 20
Personal research 11
Expense 4
Change in health plan coverage 1
See all 179 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients
1 - 6 months 9
6 months - 1 year 4
1 - 2 years 14
2 - 5 years 19
5 - 10 years 40
10 years or more 39

Stopped taking Diphenhydramine

Duration Patients
Less than 1 month 59
1 - 6 months 37
6 months - 1 year 24
1 - 2 years 16
2 - 5 years 20
5 - 10 years 8
10 years or more 18
Adherence
Adherence Evaluations
Always 149
Usually 70
Sometimes 36
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 2
Somewhat hard to take 17
A little hard to take 33
Not at all hard to take 214
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 0
$50-99 1
$25-49 7
< $25 139
Not specified 118

What people switch to and from

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients
Hydroxyzine (Vistaril) 4
Trazodone (Desyrel) 1
Last updated:

22 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for Allergic contact dermatitis)
  • Side effects
    Mild (Dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for Insomnia)
  • Side effects
    Mild (Dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks

Dec 15, 2015 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Tremor(s))
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I stopped taking this because of its possible link to dementia
Cost: < $25 monthly

Dec 17, 2012 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Tremor(s))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I take benadryl to help calm my tremor - it seems to help.
Cost: < $25 monthly

Apr 11, 2010 (Started Jan 01, 2009)

  • Effectiveness
    Slight (for Tremor(s))
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I take 2 25 mg tabs before activities such as oil painting or going to the gym to help mitigate my tremors. I believe the dose helps keep my tremors in check. THe effect may be from the benadryl or a placebo effect, but it seems to take the edge off my tremors.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 22 patient evaluations for Diphenhydramine