What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Simply Sleep Show all

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See also: Acetaminophen (paracetamol)-diphenhydramine-phenylephrine Acetaminophen (paracetamol)-diphenhydramine-pseudoephedrine Advil PM Benadryl Allergy Sinus Headache Tylenol Complete Tylenol Extra Strength PM

Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 188 86
Allergies 176 59
Food allergy 51 20
Sleep problems 27 9
Anaphylaxis 25 10
Itching 23 9

Show all 139 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 14
Moderate 55
Mild 65
None 110

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients
Drowsiness 27
Sleepiness 19
Dry mouth 11
Excessive daytime sleepiness (somnolence) 8
Groggy in morning 8
Brain fog 6

Show all 54 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients
25mg as needed 22
50 mg daily 19
2 25mg as needed 12
25 mg daily 11
50mg as needed 9
25 mg twice daily 6
100 mg daily 5
2 50mg as needed 3
50 mg every other week 2
75 mg daily 2

See all 27 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients
Other 58
Did not seem to work 46
Course of treatment ended 34
Doctor's advice 27
Side effects too severe 18
Personal research 10
Expense 4
Change in health plan coverage 1
See all 175 patients who’ve stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients
Less than 1 month 1
1 - 6 months 2
6 months - 1 year 10
1 - 2 years 10
2 - 5 years 24
5 - 10 years 32
10 years or more 33

Stopped taking Diphenhydramine

Duration Patients
Less than 1 month 59
1 - 6 months 37
6 months - 1 year 24
1 - 2 years 16
2 - 5 years 18
5 - 10 years 8
10 years or more 16
Adherence
Adherence Evaluations
Always 138
Usually 61
Sometimes 34
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 2
Somewhat hard to take 15
A little hard to take 33
Not at all hard to take 194
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 0
$50-99 1
$25-49 7
< $25 132
Not specified 104

What people switch to and from

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients
Hydroxyzine (Vistaril) 4
Trazodone (Desyrel) 1
Last updated:

22 patient evaluations for Diphenhydramine

192 members have decided to share their profiles only with other members of PatientsLikeMe.

25yrRA
34004 thumb
25yrRA
Data Quality: 1 star
  • Gender: F
  • Age: 55
Condition: Rheumatoid Arthritis (RA) 20 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See 25yrRA's full Diphenhydramine history

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for Allergic contact dermatitis)
  • Side effects
    Mild (Dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks
25yrRA
34004 thumb
25yrRA
Data Quality: 1 star
  • Gender: F
  • Age: 55
Condition: Rheumatoid Arthritis (RA) 20 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See 25yrRA's full Diphenhydramine history

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for Insomnia)
  • Side effects
    Mild (Dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks
J.Marley
20395 thumb
J.Marley
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See J.Marley's full Diphenhydramine history

Dec 15, 2015 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Tremor(s))
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I stopped taking this because of its possible link to dementia
Cost: < $25 monthly

Dec 17, 2012 (Started Jan 01, 2009)

  • Effectiveness
    Can’t tell (for Tremor(s))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I take benadryl to help calm my tremor - it seems to help.
Cost: < $25 monthly

Apr 11, 2010 (Started Jan 01, 2009)

  • Effectiveness
    Slight (for Tremor(s))
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I take 2 25 mg tabs before activities such as oil painting or going to the gym to help mitigate my tremors. I believe the dose helps keep my tremors in check. THe effect may be from the benadryl or a placebo effect, but it seems to take the edge off my tremors.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 22 patient evaluations for Diphenhydramine