What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Nightime Sleepaid Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 207 96
Food allergy 54 28
Itching 37 14
Anaphylaxis 27 15
Chemical/venom allergy 13 11

Show all 149 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 19
Moderate 60
Mild 78
None 122

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients
Drowsiness 32
Sleepiness 22
Dry mouth 12
Excessive daytime sleepiness (somnolence) 8
Groggy in morning 8
Brain fog 6

Show all 62 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients
25mg as needed 30
2 25mg as needed 22
50 mg daily 21
25 mg daily 18
50mg as needed 9
50 mg twice daily 5
25 mg twice daily 3
75 mg daily 3
100 mg daily 3
50 mg four times daily 3

See all 36 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients
Other 66
Did not seem to work 47
Course of treatment ended 35
Doctor's advice 31
Side effects too severe 22
Personal research 11
Expense 5
Change in health plan coverage 1
See all 190 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients
1 - 6 months 9
6 months - 1 year 10
1 - 2 years 14
2 - 5 years 24
5 - 10 years 43
10 years or more 45

Stopped taking Diphenhydramine

Duration Patients
Less than 1 month 66
1 - 6 months 35
6 months - 1 year 25
1 - 2 years 19
2 - 5 years 22
5 - 10 years 8
10 years or more 19
Adherence
Adherence Evaluations
Always 161
Usually 70
Sometimes 37
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 4
Somewhat hard to take 17
A little hard to take 36
Not at all hard to take 222
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 0
$50-99 1
$25-49 7
< $25 144
Not specified 126

What people switch to and from

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients
Hydroxyzine (Vistaril) 4
Diphenhydramine (IV or IM) (Benadryl IV) 1
Trazodone (Desyrel) 1
Last updated:

24 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for allergic contact dermatitis)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Sep 16, 2016 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for insomnia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 24 patient evaluations for Diphenhydramine