What is Imipramine?

Category: Prescription Drugs

Most popular types: Tofranil Tofranil-PM Tolerade

false

Imipramine is a tricyclic antidepressant used for the treatment of depression; treatment of nocturnal enuresis in children. Off label it is used as an analgesic for certain chronic and neuropathic pain; panic disorder; and attention-deficit/hyperactivity disorder (ADHD).

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 26 6
Fibromyalgia 15 6
Major Depressive Disorder 8 17
Pain 8 3
Bladder problems 7 9
Anxious mood 4 0

Show all 56 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 6
Moderate 10
Mild 11
None 31

Commonly reported side effects and conditions associated with Imipramine

Side effect Patients
Dry mouth 9
Constipation 3
Difficulty with orgasm 3
Blurry vision 2
Excessive daytime sleepiness (somnolence) 2
Breast enlargement 1

Show all 29 reported side effects

Dosages

Based on patients currently taking Imipramine

Dosage Patients
10 mg daily 3
25 mg daily 2
0.5 mg daily 1
20 mg daily 1
25 mg three times daily 1
50 mg twice daily 1

Why patients stopped taking Imipramine

Multiple reasons could be selected

Reason Patients
Did not seem to work 19
Side effects too severe 11
Other 7
Doctor's advice 5
Course of treatment ended 4
Change in health plan coverage 2
Expense 2
Personal research 1
See all 39 patients who’ve stopped taking Imipramine

Duration

Currently taking Imipramine

Duration Patients
1 - 6 months 2
6 months - 1 year 1
1 - 2 years 1
2 - 5 years 1
5 - 10 years 3
10 years or more 1

Stopped taking Imipramine

Duration Patients
Less than 1 month 7
1 - 6 months 9
6 months - 1 year 8
1 - 2 years 3
2 - 5 years 5
5 - 10 years 4
10 years or more 3
Adherence
Adherence Evaluations
Always 56
Usually 2
Sometimes 0
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 2
A little hard to take 4
Not at all hard to take 51
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 0
$50-99 0
$25-49 9
< $25 30
Not specified 19

What people switch to and from

Patients started taking Imipramine after stopping:

Treatment Patients
Nortriptyline (Pamelor) 2
Bupropion (Wellbutrin XL) 1
Clomipramine (Anafranil) 1
Duloxetine (Cymbalta) 1
Gabapentin (Neurontin) 1

Show all 7 treatments patients report switching from

Patients stopped taking Imipramine and switched to:

Treatment Patients
Amitriptyline (Elavil) 2
Carbamazepine (Tegretol) 1
Lamotrigine (Lamictal) 1
Last updated:

3 patient evaluations for Imipramine

36 members have decided to share their profiles only with other members of PatientsLikeMe.

thjuland
647 thumb
thjuland
Sex: M
Data Quality: 3 stars
Sensation: Mild
Overall: Mild
Cognition: moderate
Vision: moderate
Speech: mild
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: vg
I have:
MS

See thjuland's full Imipramine history

Mar 25, 2016 (Started Dec 24, 2008)

  • Effectiveness
    Major (for Sleep problems)
  • Effectiveness
    Major (for Nocturia)
  • Effectiveness
    Major (for Bladder problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: This remains an effective treatment that allows me to sleep through the night, without needing to pee.
Cost: < $25 monthly

Sep 19, 2015 (Started Dec 24, 2008)

  • Effectiveness
    Major (for Sleep problems)
  • Effectiveness
    Major (for Nocturia)
  • Effectiveness
    Major (for Bladder problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: Taking 2 pills a night remains very effective.
Cost: < $25 monthly

Jan 24, 2012 (Started Dec 24, 2008)

  • Effectiveness
    Major (for Bladder problems)
  • Effectiveness
    Major (for minimize night time bathroom trips)
  • Effectiveness
    Major (for prolong sleeping time periods)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: Increasing the dosage to 20mg a night has enabled me to sleep uninterrupted for a significantly longer time period. I now usually stay asleep for between six to ten hours. Plus I don't have to immediately pee upon waking.
Cost: < $25 monthly

Jun 24, 2011 (Started Dec 24, 2008)

  • Effectiveness
    Major (for Bladder problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: I'm using this to cut down on the number of night time bathroom visits I need, which helps me have a longer, more restful sleep. Next month I should be able to split my Vesicare dosage (daytime bladder control), so I will see if the delayed second dose, will extend its benefits to the evening as well.
Cost: < $25 monthly

Jan 13, 2009 (Started Dec 24, 2008)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Advice & Tips: Just one 10mg pill each evening, has decreased my night time bathroom trips from 4 to 1. Before starting treatment, I had to get up and go every 2 hours. This lengthened to every 4 hours, after about a week and now after a month I'm good for 6 - 8 hours.
Cost: < $25 monthly

  • 0 helpful marks
Gr8fulAnnie
23295 thumb
Gr8fulAnnie
Gender: F
Data Quality: 1 star
Pain: All
Fatigue: Most
Sleep: Most
Stiffness: All
function: Little
external_stress: Some
Stickman: all
Description:F56y
FM:20y Dx
CFS:?y
I am: vb
I have:
Fibromyalgia

See Gr8fulAnnie's full Imipramine history

Oct 23, 2010 (Started Jan 01, 2009)

  • Effectiveness
    Major (for Sleep problems)
  • Effectiveness
    Can’t tell (for Bipolar mixed episodes)
  • Side effects
    Severe (Sudden onset of sleep, Morning sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily
Advice & Tips: When this medication is increased by even 50mg, I fall asleep without knowing it within an hour from the drowsiness/grogginess. It had meant I need to make sure I'm not holding anything I can spill or break, or a lit cigarette. This small increase also means the hangover effect is more severe on waking. (Of course, if I were able to stay asleep more than 2-4 hours, the hangover effect would probably not be so strong.) ;)
Cost: < $25 monthly
Side effects: Sudden onset of sleep, Morning sleepiness

Jul 27, 2010 (Started Jan 01, 2009)

  • Effectiveness
    Moderate (for Sleep problems)
  • Effectiveness
    Moderate (for Bipolar mixed episodes)
  • Side effects
    Mild (Sudden onset of sleep, Morning sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily
Advice & Tips: Although an "older" antidepressant, the side effect of drowsiness helps with sleep.
Cost: < $25 monthly
Side effects: Sudden onset of sleep, Morning sleepiness

  • 0 helpful marks
Miksirch
53392 thumb
Miksirch
Sex: F
Data Quality: 1 star
Sensation: Moderate
Overall: Moderate
Cognition: moderate
Vision: moderate
Speech: moderate
Swallowing: moderate
Upper limb: moderate
Walking: moderate
I am: n
I have:
MS

See Miksirch's full Imipramine history

Dec 18, 2009 (Started Feb 14, 2008)

  • Effectiveness
    Can’t tell (for Don't know)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily
Advice & Tips: Another med to take as part of migraine regimen. I didn't want so many meds in my system.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Imipramine