What is Deplin?

Category: Supplements

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Generic name: Methylfolate (l-methylfolate)

Deplin™ is a brand name formulation of methylfolate (l-methylfolate). It is needed by depressed patients with suboptimal folate levels to regulate the synthesis of serotonin, norepinephrine and dopamine. L-methylfolate improves the benefits of antidepressants when taken together.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Increase effect of another treatment 44 22
Depressed mood 22 8
Major depressive disorder 19 22
Fatigue 4 2
Methylenetetrahydrofolate reductase deficiency 4 3
Bipolar disorder 3 5

Show all 22 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
0
Moderate
2
Mild
6
None
52

Commonly reported side effects and conditions associated with Deplin

Side effect Patients
Dizziness 1
Possible cause of hives 1
Sleepiness 1
Upset stomach 1
Wakefulness 1
Weight gain 1

Dosages

Based on patients currently taking Deplin

Dosage Patients
15 mg daily 6
7.5 mg daily 3
1 mg daily 2
60 mg daily 1

Why patients stopped taking Deplin

Multiple reasons could be selected

Reason Patients
Did not seem to work 20
Expense 13
Doctor's advice 6
Other 6
Course of treatment ended 3
Change in health plan coverage 2
Side effects too severe 1
See all 38 patients who've stopped taking Deplin

Duration

Currently taking Deplin

Duration Patients
Less than 1 month 1
1 - 6 months 2
1 - 2 years 2
2 - 5 years 1
5 - 10 years 6

Stopped taking Deplin

Duration Patients
Less than 1 month 3
1 - 6 months 19
6 months - 1 year 5
1 - 2 years 7
2 - 5 years 3
5 - 10 years 1
Adherence
Adherence Evaluations
Always 49
Usually 9
Sometimes 1
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 2
A little hard to take 8
Not at all hard to take 49
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 4
$50-99 14
$25-49 10
< $25 11
Not specified 21
Last updated:

6 patient evaluations for Deplin

Jun 30, 2016 (Started Oct 15, 2012)

  • Effectiveness
    Moderate (for Increase effect of another treatment)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily
Cost: $50-99 monthly

Feb 25, 2013 (Started Oct 15, 2012)

  • Effectiveness
    Major (for Increase effect of another treatment)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks

Aug 5, 2012 (Started Jan 12, 2012)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Major (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Moderate (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily
Cost: $50-99 monthly

Aug 4, 2012 (Started Jan 12, 2012)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Can’t tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Can’t tell (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily

  • 0 helpful marks

Jul 29, 2009 (Started Jun 17, 2009)

  • Effectiveness
    Moderate (for depression, might help fibro?)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 6 patient evaluations for Deplin