What is Deplin?

Category: Supplements

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Generic name: Methylfolate (l-methylfolate)

Deplin™ is a brand name formulation of methylfolate (l-methylfolate). It is needed by depressed patients with suboptimal folate levels to regulate the synthesis of serotonin, norepinephrine and dopamine. L-methylfolate improves the benefits of antidepressants when taken together.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Increase effect of another treatment 41 18
Depressed mood 19 6
Major Depressive Disorder 16 18
Fatigue 4 2
Methylenetetrahydrofolate Reductase Deficiency 4 1
Bipolar Disorder 3 5

Show all 22 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 0
Moderate 2
Mild 6
None 47

Commonly reported side effects and conditions associated with Deplin

Side effect Patients
Dizziness 1
Possible cause of hives 1
Sleepiness 1
Stomach upset 1
Wakefulness 1
Weight gain 1

Dosages

Based on patients currently taking Deplin

Dosage Patients
7.5 mg daily 5
15 mg daily 5
1 mg daily 1
20 mg daily 1
60 mg daily 1

Why patients stopped taking Deplin

Multiple reasons could be selected

Reason Patients
Did not seem to work 19
Expense 10
Other 6
Doctor's advice 4
Course of treatment ended 2
Change in health plan coverage 1
Side effects too severe 1
See all 33 patients who’ve stopped taking Deplin

Duration

Currently taking Deplin

Duration Patients
1 - 6 months 2
6 months - 1 year 1
1 - 2 years 1
2 - 5 years 5
5 - 10 years 4

Stopped taking Deplin

Duration Patients
Less than 1 month 4
1 - 6 months 19
6 months - 1 year 3
1 - 2 years 5
2 - 5 years 2
Adherence
Adherence Evaluations
Always 47
Usually 6
Sometimes 1
Never taken as prescribed 1
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 2
A little hard to take 10
Not at all hard to take 42
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 3
$50-99 14
$25-49 9
< $25 10
Not specified 19
Last updated:

6 patient evaluations for Deplin

40 members have decided to share their profiles only with other members of PatientsLikeMe.

FibroMom63
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FibroMom63
Gender: F
Data Quality: 1 star
Pain: Some
Fatigue: All
Sleep: Most
Stiffness: All
function: None
external_stress: Some
Stickman: most
Description:F52y
FM:13y Dx
CFS:24y Dx
I am: b
I have:
Fibromyalgia

See FibroMom63's full Deplin history

Feb 25, 2013 (Started Oct 15, 2012)

  • Effectiveness
    Major (for Increase effect of another treatment)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks
Cee Kay
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Cee Kay
Gender: F
Data Quality: 1 star
Pain: Little
Fatigue: Most
Sleep: Little
Stiffness: Little
function: Some
external_stress: Little
Stickman: little
Description:F72y
CFS:21y Dx
I am: n
I have:
ME/CFS

See Cee Kay's full Deplin history

Aug 5, 2012 (Started Jan 12, 2012)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Major (for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Effectiveness
    Moderate (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily
Cost: $50-99 monthly

Aug 4, 2012 (Started Jan 12, 2012)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Can’t tell (for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome)
  • Effectiveness
    Can’t tell (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily

  • 0 helpful marks
wanttoteach
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wanttoteach
Gender: F
Data Quality: 0 stars
Pain: Some
Fatigue: Most
Sleep: Most
Stiffness: All
function: Some
external_stress: Some
Stickman: most
Description:F60y
FM:9y Dx
I have:
Fibromyalgia

See wanttoteach's full Deplin history

Jul 29, 2009 (Started Jun 17, 2009)

  • Effectiveness
    Moderate (for depression, might help fibro?)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 6 patient evaluations for Deplin