What is Tizanidine?

Category: Prescription Drugs

Most popular types: Zanaflex Sirdalud Sirdalud Retard Show all

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Tizanidine hydrochloride is a skeletal muscle relaxant used for treatment of muscle spasticity. It may also be used for tension headaches, low back pain, and trigeminal neuralgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Stiffness/spasticity 853 318
Muscle spasms 658 258
Fibromyalgia 345 126
Muscle pain 88 32
Pain 83 45
Muscle spasms in neck and shoulders 58 17

Show all 158 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
68
Moderate
171
Mild
182
None
260

Commonly reported side effects and conditions associated with Tizanidine

Side effect Patients
Sleepiness 76
Drowsiness 62
Dry mouth 46
Fatigue 28
Excessive daytime sleepiness (somnolence) 26
Dizziness 18

Show all 130 reported side effects

Dosages

Based on patients currently taking Tizanidine

Dosage Patients
4 mg daily 69
8 mg daily 35
4 mg twice daily 29
4 mg three times daily 29
2 mg daily 24
4mg as needed 23
12 mg daily 19
2 mg three times daily 17
6 mg daily 11
4 mg four times daily 9

See all 40 dosages

Why patients stopped taking Tizanidine

Multiple reasons could be selected

Reason Patients
Did not seem to work 153
Side effects too severe 86
Doctor's advice 76
Other 75
Course of treatment ended 20
Personal research 17
Expense 12
Change in health plan coverage 7
See all 370 patients who've stopped taking Tizanidine

Duration

Currently taking Tizanidine

Duration Patients
Less than 1 month 2
1 - 6 months 23
6 months - 1 year 35
1 - 2 years 45
2 - 5 years 92
5 - 10 years 94
10 years or more 51

Stopped taking Tizanidine

Duration Patients
Less than 1 month 59
1 - 6 months 102
6 months - 1 year 53
1 - 2 years 60
2 - 5 years 59
5 - 10 years 27
10 years or more 12
Adherence
Adherence Evaluations
Always 476
Usually 122
Sometimes 61
Never taken as prescribed 22
Burden
Burden Evaluations
Very hard to take 33
Somewhat hard to take 36
A little hard to take 93
Not at all hard to take 519
Cost per month
Cost per month Evaluations
$200+ 3
$100-199 0
$50-99 16
$25-49 44
< $25 369
Not specified 249

What people switch to and from

Patients started taking Tizanidine after stopping:

Treatment Patients
Cyclobenzaprine (Flexeril) 49
Baclofen (Mylan-Baclofen) 35
Carisoprodol (Soma) 11
Diazepam (Valium) 3
Hydrocodone-Acetaminophen (Norco) 3

Show all 31 treatments patients report switching from

Patients stopped taking Tizanidine and switched to:

Treatment Patients
Baclofen (Mylan-Baclofen) 24
Cyclobenzaprine (Flexeril) 8
Clonazepam (Klonopin) 3
Methocarbamol (Robaxin) 3
Baclofen intrathecal pump (Lioresal) 2

Show all 20 treatments patients report switching to

Last updated:

85 patient evaluations for Tizanidine

Jul 2, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (muscle fatigue, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Mar 5, 2017 (Started Sep 10, 1999)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    Mild (muscle fatigue, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Sep 7, 2012 (Started Sep 10, 1999)

  • Effectiveness
    Major (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Feb 9, 2009 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

Sep 7, 2008 (Started Sep 10, 1999)

  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Side effects
    Mild (muscle fatigue, dry mouth)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: This medication served me very well for several yrs. after I'd exhausted the use of Baclofen, which had become totally ineffective for me. This medication is not instant in terms of effectiveness. I had to "wean off" of the Baclofen & "ramp up" the dosage of Zanaflex & maintain a consistent level of this medication (in my bloodstream) before it became truly effective. After it became ineffective singularly, I began using it in combination with Keppra & I'm still realizing positive results using this regimen. I do experience some minor muscle fatigue & occasional dry mouth while using Zanaflex, however nothing close in terems of negative side effects as compared to Baclofen.
Cost: < $25 monthly
Side effects: dry mouth, muscle fatigue

  • 0 helpful marks

Aug 30, 2016 (Started Jul 15, 2013)

  • Effectiveness
    Moderate (for stiffness/spasticity)
  • Effectiveness
    Moderate (for neck pain)
  • Side effects
    Mild (drowsiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks

Apr 13, 2016 (Started Apr 15, 2016)

  • Effectiveness
    Slight (for stiffness/spasticity)
  • Side effects
    Severe (dry mouth, drowsiness)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 4 mg Four times daily
Advice & Tips: If you have to be alert, avoid it. Keep a drink close.

  • 0 helpful marks
Last updated:
Showing 3 of 85 patient evaluations for Tizanidine