What is Carbidopa Levodopa ER?

Category: Prescription Drugs

Most popular types: Rytary XR

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An extended-release preparation of carbidopa/levodopa formulated to release a lower, smoother dose of medication over an extended period of time.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 143 188
Stiffness/spasticity 10 16
Multiple system atrophy 5 6
Dystonia 2 3
Multiple sclerosis 2 5

Show all 20 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 18
Moderate 31
Mild 61
None 85

Commonly reported side effects and conditions associated with Carbidopa Levodopa ER

Side effect Patients
Jerky movements 14
Nausea 7
Constipation 4
Dystonia 4
Balance problems 2
Dizziness 2

Show all 56 reported side effects

Dosages

Based on patients currently taking Carbidopa Levodopa ER

Dosage Patients
50-200 mg daily 9
23.75-95 mg three times daily 6
50 mg-200 mg daily 5
61.25-245 mg four times daily 4
25-100 mg daily 3
48.75-195 mg daily 3
2 x 36.25-145 mg four times daily 3
2 x 48.75-195 mg four times daily 3
2 capsule(s) three times daily 2
3 capsule(s) four times daily 2

See all 62 dosages

Why patients stopped taking Carbidopa Levodopa ER

Multiple reasons could be selected

Reason Patients
Side effects too severe 15
Did not seem to work 9
Doctor's advice 5
Expense 3
Change in health plan coverage 2
Other 2
Course of treatment ended 1
Personal research 1
See all 30 patients who've stopped taking Carbidopa Levodopa ER

Duration

Currently taking Carbidopa Levodopa ER

Duration Patients
1 - 6 months 7
6 months - 1 year 16
1 - 2 years 22
2 - 5 years 47
5 - 10 years 5
10 years or more 2

Stopped taking Carbidopa Levodopa ER

Duration Patients
Less than 1 month 8
1 - 6 months 10
6 months - 1 year 3
1 - 2 years 6
2 - 5 years 4
Adherence
Adherence Evaluations
Always 160
Usually 27
Sometimes 2
Never taken as prescribed 6
Burden
Burden Evaluations
Very hard to take 6
Somewhat hard to take 15
A little hard to take 37
Not at all hard to take 137
Cost per month
Cost per month Evaluations
$200+ 18
$100-199 12
$50-99 25
$25-49 30
< $25 63
Not specified 47

What people switch to and from

Patients started taking Carbidopa Levodopa ER after stopping:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 74
Carbidopa-Entacapone-Levodopa (Stalevo) 12
Entacapone (Comtan) 10
Carbidopa-Levodopa CR (Sinemet CR) 5
Pramipexole (Mirapex) 4

Show all 11 treatments patients report switching from

Patients stopped taking Carbidopa Levodopa ER and switched to:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 14
Carbidopa-Entacapone-Levodopa (Stalevo) 3
Carbidopa Levodopa ER (Rytary XR) 3
Carbidopa-Levodopa CR (Sinemet CR) 2
Selegiline (Zelapar) 1
Last updated:

12 patient evaluations for Carbidopa Levodopa ER

Jun 6, 2018 (Started Jul 31, 2015)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 48.75-195 mg Four times daily
Advice & Tips: I have now found that I can get out of bed and walk better if the Ryatry is "working". I would not say it "kicks in". It is more like the effect slowly works it's way into my brain. dosage: 1 48.75-195 mg dose eveery 4 hours 4:30am, 8:30am, 12:30pm, 4:30pm
Cost: < $25 monthly

Sep 30, 2017 (Started Jul 31, 2015)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 48.75-195 mg Four times daily
Advice & Tips: My dose schedule is 1 capsule very four hours. 6am 10am 2pm 6pm IT seems I need at least 2-4 hrs in my system before I get out of bed. I can get tremors after 9pm, but the additional modafinil and cymbalta could be part of it. Also, my neurologist noted dyskenesia at my yearly visit (8/30/17). We tried bumping down from 195 mg to 145 mg in case I developed more sensitivity, hence needing less. Nope, after about 6 days I returnd to the 195 mg dose.
Cost: < $25 monthly

Mar 6, 2017 (Started Jul 31, 2015)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 48.75-195 mg Four times daily
Advice & Tips: I am happy with the effectiveness with Rytary compared to Sinemet. I tried 4x a day, but i got wiggly in the evening. Yet, if I had to be out and about in the evening, I would take the 4th dose. I wonder if I'm more wakeful with Rytary and need less modafinil?
Cost: < $25 monthly

Sep 23, 2016 (Started Jul 31, 2015)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 48.75-195 mg Four times daily
Advice & Tips: I noticed a lack of effectiveness in early August. Neurologist said to add one 25/100 carbidopa/levadopa to the the 36.25/145 mg Rytary dose. After couple weeks it seemed to be enough. At that point I started one dose 48.75-195 mg four times daily. It is acceptable. I take it every 4 hours , starting at 6am. Sometimes I don't take the 6pm dose.
Cost: < $25 monthly

Jul 21, 2016 (Started Jul 31, 2015)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 36.25-145 mg Four times daily
Advice & Tips: Rytary has smoothed out the peaks and valleys. It took about 6 weeks of futzing with the timing. I was pleasantly surprised. It makes it easier to predict the days outings I'm able to trust my body. Note: my insurance is a HDHP so my cost varies from 100% of negotiated cost, to 20%, to 0%.
Cost: $25-49 monthly

  • 1 helpful mark

May 22, 2018 (Started Apr 05, 2016)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 capsule(s) Four times daily
Advice & Tips: This is frustrating medicine. I have to be extremely cautious with this medication regarding time. if you are hoping you will have up to 90 min to wait. I have going off med dyskinesia and with Rytary driving the train it creates a violent ,exhausting dyskinesia
Cost: $50-99 monthly

May 5, 2017 (Started Apr 05, 2016)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 capsule(s) Four times daily
Advice & Tips: I like feeling as normal as possible. and my meds make it posssible/
Cost: $50-99 monthly

Oct 22, 2016 (Started Apr 05, 2016)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 23.75-95 mg Twice daily
Advice & Tips: it takes a while to work into the system and my muscles are more loose and supple while it is "on"
Cost: $50-99 monthly

  • 0 helpful marks

May 1, 2018 (Started Feb 19, 2016)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Moderate (leaning to the left)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 2 x 61.25-245 mg Four times daily
Advice & Tips: It has dissolved the muscle on the right side of my back, next to my spine. The left side of my back is fine. So it is impossible to walk straight up.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 12 patient evaluations for Carbidopa Levodopa ER