What is Natalizumab?

Category: Prescription Drugs

Most popular types: Tysabri Antegren

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Natalizumab is a monoclonal antibody given by infusion and used in the treatment of MS and Crohn's disease. It has been shown to slow progression and reduce relapses in MS. 

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 2,072 1,424
Improve mobility 49 40
General health 32 20
Fatigue 26 18
Stiffness/spasticity 20 15
Nerve pain (neuralgia) 9 12

Show all 30 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 77
Moderate 127
Mild 409
None 834

Commonly reported side effects and conditions associated with Natalizumab

Side effect Patients
Headaches 92
Tiredness 64
Fatigue 63
Fear of PML 23
Nausea 20
Allergic reaction 16

Show all 288 reported side effects

Dosages

Based on patients currently taking Natalizumab

Dosage Patients
300 mg/15 mL monthly 76
300 mg/15 mL every 4 weeks 61
300 mg/15ml every 4 weeks 32
300 mg/15ml monthly 26
300 mg monthly 3
300 mg/15ml every 6 weeks 2
300 mg every 4 weeks 2
300 x 300 mg/15ml every 4 weeks 2
1 other monthly 1
120 mL every 4 weeks 1

See all 20 dosages

Why patients stopped taking Natalizumab

Multiple reasons could be selected

Reason Patients
Doctor's advice 283
Other 225
Side effects too severe 192
Did not seem to work 149
Personal research 56
Course of treatment ended 29
Expense 28
Change in health plan coverage 18
See all 696 patients who've stopped taking Natalizumab

Duration

Currently taking Natalizumab

Duration Patients
1 - 6 months 4
6 months - 1 year 11
1 - 2 years 20
2 - 5 years 63
5 - 10 years 113
10 years or more 15

Stopped taking Natalizumab

Duration Patients
Less than 1 month 65
1 - 6 months 134
6 months - 1 year 109
1 - 2 years 165
2 - 5 years 187
5 - 10 years 38
10 years or more 3
Adherence
Adherence Evaluations
Always 1346
Usually 56
Sometimes 9
Never taken as prescribed 36
Burden
Burden Evaluations
Very hard to take 47
Somewhat hard to take 177
A little hard to take 423
Not at all hard to take 800
Cost per month
Cost per month Evaluations
$200+ 180
$100-199 49
$50-99 68
$25-49 85
< $25 526
Not specified 539

What people switch to and from

Patients started taking Natalizumab after stopping:

Treatment Patients
Glatiramer acetate (Copaxone) 76
Interferon beta-1a IM Injection (Avonex) 45
Interferon beta-1a SubQ injection (Rebif) 44
Dimethyl fumarate (Tecfidera) 32
Interferon beta-1b SubQ Injection (Betaseron) 24

Show all 17 treatments patients report switching from

Patients stopped taking Natalizumab and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 39
Fingolimod (Gilenya) 37
Rituximab (Rituxan) 16
Teriflunomide (Aubagio) 13
Glatiramer acetate (Copaxone) 12

Show all 17 treatments patients report switching to

Last updated:

111 patient evaluations for Natalizumab

Jul 9, 2017 (Started Jun 30, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/15ml Monthly

  • 0 helpful marks

Feb 27, 2017 (Started Jan 15, 2011)

  • Effectiveness
    Major (for multiple sclerosis)
  • Effectiveness
    None (for Improve mobility)
  • Effectiveness
    Major (for General health)
  • Side effects
    Moderate (bowel problems, walking slower)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 300 mg/15 mL every 4 weeks
Advice & Tips: I completed almost five years on Tysabri. Unfortunately I was diagnosed with breast cancer this month. had to stop it and move to Rebif.

  • 0 helpful marks

Jan 19, 2017 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Headaches last two Days... Stress for the most part!! ReLax and Breathe!!
Cost: $25-49 monthly

Dec 14, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: 5th IV Today... feeling great now...took wrong turn coming home..now on to meet client's and then HOME to see my husband!! It's his Birthday 59!!
Cost: $25-49 monthly

Dec 6, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Doing well only four times to the restroom during treatment~
Cost: $25-49 monthly

Dec 3, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Cost: $25-49 monthly

Nov 22, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: I had water and drank water all week before treatment..stay away from alcohol
Cost: $25-49 monthly

Sep 17, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Bring something to drink and read when getting IV!
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 111 patient evaluations for Natalizumab