What is Natalizumab?

Category: Prescription Drugs

Most popular types: Tysabri Antegren

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Natalizumab is a monoclonal antibody given by infusion and used in the treatment of MS and Crohn's disease. It has been shown to slow progression and reduce relapses in MS. 

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
multiple sclerosis 2,047 1,405
Improve mobility 49 40
General health 32 20
Fatigue 26 18
Stiffness/Spasticity 20 15
Nerve pain (neuralgia) 9 12

Show all 34 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 76
Moderate 126
Mild 401
None 825

Commonly reported side effects and conditions associated with Natalizumab

Side effect Patients
Headaches 90
Tiredness 63
Fatigue 60
Fear of PML 23
Nausea 19
Allergic reaction 16

Show all 285 reported side effects

Dosages

Based on patients currently taking Natalizumab

Dosage Patients
300 mg/15 mL monthly 80
300 mg/15 mL every 4 weeks 68
300 mg/15ml every 4 weeks 32
300 mg/15ml monthly 24
monthly 4
300 mg every 4 weeks 3
300 mg/15 mL every 6 weeks 2
300 mg monthly 2
1 other monthly 1
120 mL every 4 weeks 1

See all 21 dosages

Why patients stopped taking Natalizumab

Multiple reasons could be selected

Reason Patients
Doctor's advice 280
Other 216
Side effects too severe 188
Did not seem to work 145
Personal research 56
Course of treatment ended 29
Expense 28
Change in health plan coverage 18
See all 680 patients who've stopped taking Natalizumab

Duration

Currently taking Natalizumab

Duration Patients
Less than 1 month 1
1 - 6 months 5
6 months - 1 year 15
1 - 2 years 23
2 - 5 years 63
5 - 10 years 116
10 years or more 14

Stopped taking Natalizumab

Duration Patients
Less than 1 month 62
1 - 6 months 132
6 months - 1 year 106
1 - 2 years 163
2 - 5 years 184
5 - 10 years 35
10 years or more 3
Adherence
Adherence Evaluations
Always 1328
Usually 55
Sometimes 9
Never taken as prescribed 36
Burden
Burden Evaluations
Very hard to take 46
Somewhat hard to take 175
A little hard to take 418
Not at all hard to take 789
Cost per month
Cost per month Evaluations
$200+ 179
$100-199 48
$50-99 67
$25-49 85
< $25 517
Not specified 532

What people switch to and from

Patients started taking Natalizumab after stopping:

Treatment Patients
Glatiramer acetate (Copaxone) 67
Interferon beta-1a IM Injection (Avonex) 43
Interferon beta-1a SubQ injection (Rebif) 39
Dimethyl fumarate (Tecfidera) 31
Interferon beta-1b SubQ Injection (Betaseron) 21

Show all 16 treatments patients report switching from

Patients stopped taking Natalizumab and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 36
Fingolimod (Gilenya) 32
Rituximab (Rituxan) 15
Glatiramer acetate (Copaxone) 12
Teriflunomide (Aubagio) 12

Show all 16 treatments patients report switching to

Last updated:

110 patient evaluations for Natalizumab

Basma
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Basma
Sex: F
Data Quality: 0 stars
Sensation: Moderate
Overall: None
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: mild
I am: n
I have:
MS

See Basma's full Natalizumab history

Feb 27, 2017 (Started Jan 15, 2011)

  • Effectiveness
    Major (for multiple sclerosis)
  • Effectiveness
    None (for Improve mobility)
  • Effectiveness
    Major (for General health)
  • Side effects
    Moderate (Bowel problems, Walking slower)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 300 mg/15 mL every 4 weeks
Advice & Tips: I completed almost five years on Tysabri. Unfortunately I was diagnosed with breast cancer this month. had to stop it and move to Rebif.

  • 0 helpful marks
MicheleBall
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MicheleBall
Sex: F
Data Quality: 1 star
Relapse: Mild
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: none
Speech: moderate
Swallowing: moderate
Upper limb: mild
Walking: mild
I am: g
I have:
MS

See MicheleBall's full Natalizumab history

Jan 19, 2017 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Headaches last two Days... Stress for the most part!! ReLax and Breathe!!
Cost: $25-49 monthly

Dec 14, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: 5th IV Today... feeling great now...took wrong turn coming home..now on to meet client's and then HOME to see my husband!! It's his Birthday 59!!
Cost: $25-49 monthly

Dec 6, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Doing well only four times to the restroom during treatment~
Cost: $25-49 monthly

Dec 3, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Cost: $25-49 monthly

Nov 22, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: I had water and drank water all week before treatment..stay away from alcohol
Cost: $25-49 monthly

Sep 17, 2016 (Started Aug 24, 2016)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Bring something to drink and read when getting IV!
Cost: $25-49 monthly

  • 0 helpful marks
Seclorum
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Seclorum
Sex: M
Data Quality: 1 star
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: mild
Speech: mild
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: n
I have:
MS

See Seclorum's full Natalizumab history

Jul 20, 2016 (Started Jun 22, 2016)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    Mild (Fever)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Advice & Tips: Feel slightly energetic for a few days after treatment. The side effect, fever, is for about an hour post infusion and it hits about 99deg but some acetaminophen and some bedrest clears it up.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 110 patient evaluations for Natalizumab