What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,347 3,199
Depressed mood 2,075 1,223
Major depressive disorder 1,905 1,154
Generalized anxiety disorder 796 567
Myalgic encephalomyelitis/chronic fatigue syndrome 694 385
Pain 532 313

Show all 327 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 927
Moderate 1,013
Mild 1,141
None 1,760

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 334
Nausea 286
Dry mouth 167
Dizziness 159
Decreased sex drive (libido) 155
Sweating increased 100

Show all 740 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 408
30 mg daily 168
120 mg daily 133
60 mg twice daily 71
90 mg daily 69
20 mg daily 63
30 mg twice daily 25
40 mg daily 18
20 mg twice daily 16
120 mg twice daily 13

See all 44 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1749
Did not seem to work 1549
Doctor's advice 583
Expense 442
Other 434
Personal research 173
Change in health plan coverage 159
Course of treatment ended 70
See all 3484 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 5
1 - 6 months 37
6 months - 1 year 93
1 - 2 years 140
2 - 5 years 300
5 - 10 years 320
10 years or more 164

Stopped taking Duloxetine

Duration Patients
Less than 1 month 814
1 - 6 months 934
6 months - 1 year 549
1 - 2 years 497
2 - 5 years 515
5 - 10 years 155
10 years or more 35
Adherence
Adherence Evaluations
Always 4052
Usually 429
Sometimes 75
Never taken as prescribed 285
Burden
Burden Evaluations
Very hard to take 300
Somewhat hard to take 368
A little hard to take 573
Not at all hard to take 3600
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 191
$50-99 433
$25-49 691
< $25 1558
Not specified 1842

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 130
Venlafaxine (Effexor XR) 121
Sertraline (Zoloft) 111
Citalopram (Celexa) 97

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 77
Venlafaxine (Effexor XR) 70
Gabapentin (Neurontin) 58
Bupropion (Wellbutrin XL) 36
Escitalopram (Lexapro) 36

Show all 77 treatments patients report switching to

Last updated:

320 patient evaluations for Duloxetine

Aug 1, 2010 (Started Jun 03, 2008)

  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Moderate (for pain)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I believe this med was great for me..in order to manage other symptoms as well i was taken off this med and put on another to see if other symptoms were helped.
Cost: < $25 monthly

Aug 20, 2008 (Started Jun 03, 2008)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: Take it as prescribed and it helps the pain.If you stop taking it for a couple of days you will definitly feel the difference!!So keep taking it.
Cost: < $25 monthly

  • 1 helpful mark

Oct 28, 2010 (Started Sep 02, 2010)

  • Effectiveness
    Moderate (for fibromyalgia)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    Mild (difficulty staying asleep, wakefulness)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: Was told to take at bedtime, but left me restless and wakeful, so I take it during the morning hours now. Was lucky enough to be given samples as I have no ins coverage for this and there's no generic.
Side effects: difficulty staying asleep, wakefulness

Sep 17, 2010 (Started Sep 02, 2010)

  • Effectiveness
    Moderate (for fibromyalgia)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    Mild (difficulty staying asleep, wakefulness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I was told to take this at night to help with fibro and sciatic pain at night. I didn't sleep well, was wakeful, but did help pain. I've started taking it in the morning, and it helps the pain and I don't want to sleep as much during the day now. It has helped with pain and depression. I was given a huge bag of samples to last til next appt. Don't know the cost, but do know my ins won't cover it!
Side effects: difficulty staying asleep, wakefulness

  • 1 helpful mark

Dec 8, 2015 (Started Jul 01, 2014)

  • Effectiveness
    Major (for major depressive disorder)
  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: Do not skip doses. If you go more than 2 or 3 days you will start feeling like you have the flu.
Cost: $50-99 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 320 patient evaluations for Duloxetine