What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,887 2,900
Depressed mood 1,957 1,107
Major Depressive Disorder 1,661 1,011
Generalized Anxiety Disorder 718 506
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 686 369
Pain 518 291

Show all 345 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 863
Moderate 920
Mild 1,069
None 1,555

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 276
Nausea 273
Dizziness 157
Sex drive (libido) decreased 154
Dry mouth 152
Sweating increased 100

Show all 713 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 507
30 mg daily 221
120 mg daily 127
60 mg twice daily 93
90 mg daily 91
20 mg daily 73
30 mg twice daily 49
40 mg daily 34
120 mg twice daily 24
20 mg twice daily 9

See all 59 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1655
Did not seem to work 1441
Doctor's advice 538
Expense 428
Other 407
Personal research 159
Change in health plan coverage 151
Course of treatment ended 63
See all 3256 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 10
1 - 6 months 101
6 months - 1 year 184
1 - 2 years 240
2 - 5 years 354
5 - 10 years 332
10 years or more 134

Stopped taking Duloxetine

Duration Patients
Less than 1 month 708
1 - 6 months 931
6 months - 1 year 533
1 - 2 years 464
2 - 5 years 478
5 - 10 years 128
10 years or more 30
Adherence
Adherence Evaluations
Always 3708
Usually 385
Sometimes 63
Never taken as prescribed 251
Burden
Burden Evaluations
Very hard to take 270
Somewhat hard to take 342
A little hard to take 517
Not at all hard to take 3278
Cost per month
Cost per month Evaluations
$200+ 122
$100-199 186
$50-99 416
$25-49 652
< $25 1387
Not specified 1644

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 126
Fluoxetine (Prozac) 97
Venlafaxine (Effexor XR) 89
Sertraline (Zoloft) 81
Escitalopram (Lexapro) 73

Show all 67 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 60
Venlafaxine (Effexor XR) 55
Gabapentin (Neurontin) 39
Bupropion (Wellbutrin XL) 30
Sertraline (Zoloft) 30

Show all 66 treatments patients report switching to

Last updated:

315 patient evaluations for Duloxetine

3,571 members have decided to share their profiles only with other members of PatientsLikeMe.

Aztek350
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Aztek350
Gender: F
Data Quality: 1 star
Depression: 2
Mania: 0
Emotional: 1
Anxiety: 0
Compulsion: 1
External Stress: Low
62 F
Function: High
Distress: Low
I am: g
I have:
Persistent depressive disorder (dysthymia)

See Aztek350's full Duloxetine history

Jan 22, 2012 (Started Jul 01, 2010)

  • Effectiveness
    Moderate (for Persistent depressive disorder (dysthymia))
  • Side effects
    Mild (Constipation)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Ladywolf319
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Ladywolf319
Data Quality: 1 star
  • Gender: F
  • Age: 33
Condition: CRPS II 29 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: vb
I have:
CRPS II

See Ladywolf319's full Duloxetine history

Jan 20, 2012 (Started Dec 09, 2010)

  • Effectiveness
    None (for Fibromyalgia)
  • Effectiveness
    None (for Depressed mood)
  • Effectiveness
    Moderate (for Generalized Anxiety Disorder)
  • Effectiveness
    Slight (for Major Depressive Disorder)
  • Effectiveness
    None (for Pain in upper back)
  • Effectiveness
    None (for Pain in lower abdomen)
  • Side effects
    Mild (Weight gain, Fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 27, 2011 (Started Dec 09, 2010)

  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Effectiveness
    None (for Depressed mood)
  • Effectiveness
    Can’t tell (for Generalized Anxiety Disorder)
  • Effectiveness
    None (for Major Depressive Disorder)
  • Effectiveness
    Can’t tell (for Pain in upper back)
  • Effectiveness
    None (for Pain in lower abdomen)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
cher9912
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cher9912
Gender: F
Data Quality: 1 star
Pain: Some
Fatigue: Most
Sleep: Most
Stiffness: Most
function: Some
external_stress: Some
Stickman: most
Description:F71y
CFS:12y Dx
FM:12y Dx
I am: b
I have:
ME/CFS

See cher9912's full Duloxetine history

Jan 4, 2012 (Started Sep 25, 2004)

  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Side effects
    Mild (Dizziness and feeling faint)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: Cymbalta combined with Celebrex and gabapentin seem to keep my pain in a tolerable 3-4 on a 10 point scale. As I get older I am feeling more pain and I see physical medicine Dr. tomorrow.. will discuss options as to what is available if I {wear out} current medications. I've been on current meds for over 5 years and efficacy is decreasing. I pay $50.every three months since I turned 65.
Cost: < $25 monthly

Sep 23, 2010 (Started Sep 25, 2004)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Dizziness and feeling faint)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

Jul 21, 2010 (Started Sep 25, 2004)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Dizziness and feeling faint)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I take my full daily dose in the morning, I find that cymbalta in combination with fluoxetine has helped me deal with chronic depression and helps somewhat with brain fog of fibromyalgia & chronic fatigue. I still stress over some things, family & finances mostly and stressors can override my medications at times. I think cymbalta does help reduce some nerve pain and that is a definite impact. I have been diagnosed with neuropathy and radiculopathy and I think cymbalta helps with some of the symptoms from this.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 315 patient evaluations for Duloxetine