What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
fibromyalgia 6,017 3,004
Depressed mood 1,981 1,134
major depressive disorder 1,732 1,057
generalized anxiety disorder 748 528
myalgic encephalomyelitis/chronic fatigue syndrome 691 375
Pain 520 296

Show all 352 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 884
Moderate 954
Mild 1,093
None 1,616

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 291
Nausea 281
Dizziness 158
Dry mouth 156
Sex drive (libido) decreased 155
Sweating increased 99

Show all 726 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 549
30 mg daily 226
120 mg daily 132
90 mg daily 109
60 mg twice daily 105
20 mg daily 90
30 mg twice daily 58
40 mg daily 38
120 mg twice daily 24
20 mg twice daily 13

See all 56 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1678
Did not seem to work 1463
Doctor's advice 550
Expense 433
Other 412
Personal research 165
Change in health plan coverage 153
Course of treatment ended 66
See all 3310 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 3
1 - 6 months 98
6 months - 1 year 212
1 - 2 years 267
2 - 5 years 392
5 - 10 years 363
10 years or more 146

Stopped taking Duloxetine

Duration Patients
Less than 1 month 715
1 - 6 months 944
6 months - 1 year 540
1 - 2 years 472
2 - 5 years 489
5 - 10 years 134
10 years or more 32
Adherence
Adherence Evaluations
Always 3817
Usually 400
Sometimes 68
Never taken as prescribed 262
Burden
Burden Evaluations
Very hard to take 283
Somewhat hard to take 352
A little hard to take 535
Not at all hard to take 3377
Cost per month
Cost per month Evaluations
$200+ 122
$100-199 188
$50-99 422
$25-49 659
< $25 1452
Not specified 1704

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 132
Fluoxetine (Prozac) 106
Venlafaxine (Effexor XR) 99
Sertraline (Zoloft) 87
Citalopram (Celexa) 79

Show all 70 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 66
Venlafaxine (Effexor XR) 56
Gabapentin (Neurontin) 44
Bupropion (Wellbutrin XL) 32
Sertraline (Zoloft) 31

Show all 69 treatments patients report switching to

Last updated:

315 patient evaluations for Duloxetine

Aztek350
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Aztek350
Gender: F
Data Quality: 1 star
Depression: 2
Mania: 0
Emotional: 1
Anxiety: 0
Compulsion: 1
External Stress: Low
62 F
Function: High
Distress: Low
I am: g
I have:
Persistent depressive disorder (dysthymia)

See Aztek350's full Duloxetine history

Jan 22, 2012 (Started Jul 01, 2010)

  • Effectiveness
    Moderate (for persistent depressive disorder (dysthymia))
  • Side effects
    Mild (Constipation)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Ladywolf319
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Ladywolf319
Data Quality: 1 star
  • Gender: F
  • Age: 33
Condition: CRPS II 29 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: vb
I have:
CRPS II

See Ladywolf319's full Duloxetine history

Jan 20, 2012 (Started Dec 09, 2010)

  • Effectiveness
    None (for fibromyalgia)
  • Effectiveness
    None (for Depressed mood)
  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Effectiveness
    Slight (for major depressive disorder)
  • Effectiveness
    None (for Pain in upper back)
  • Effectiveness
    None (for Pain in lower abdomen)
  • Side effects
    Mild (Weight gain, Fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 27, 2011 (Started Dec 09, 2010)

  • Effectiveness
    Can’t tell (for fibromyalgia)
  • Effectiveness
    None (for Depressed mood)
  • Effectiveness
    Can’t tell (for generalized anxiety disorder)
  • Effectiveness
    None (for major depressive disorder)
  • Effectiveness
    Can’t tell (for Pain in upper back)
  • Effectiveness
    None (for Pain in lower abdomen)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
cher9912
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cher9912
Gender: F
Data Quality: 1 star
Pain: Some
Fatigue: Most
Sleep: Most
Stiffness: Most
function: Some
external_stress: Some
Stickman: most
Description:F71y
CFS:12y Dx
FM:12y Dx
I am: b
I have:
ME/CFS

See cher9912's full Duloxetine history

Jan 4, 2012 (Started Sep 25, 2004)

  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Can’t tell (for fibromyalgia)
  • Side effects
    Mild (Dizziness and feeling faint)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: Cymbalta combined with Celebrex and gabapentin seem to keep my pain in a tolerable 3-4 on a 10 point scale. As I get older I am feeling more pain and I see physical medicine Dr. tomorrow.. will discuss options as to what is available if I {wear out} current medications. I've been on current meds for over 5 years and efficacy is decreasing. I pay $50.every three months since I turned 65.
Cost: < $25 monthly

Sep 23, 2010 (Started Sep 25, 2004)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Dizziness and feeling faint)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

Jul 21, 2010 (Started Sep 25, 2004)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Dizziness and feeling faint)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I take my full daily dose in the morning, I find that cymbalta in combination with fluoxetine has helped me deal with chronic depression and helps somewhat with brain fog of fibromyalgia & chronic fatigue. I still stress over some things, family & finances mostly and stressors can override my medications at times. I think cymbalta does help reduce some nerve pain and that is a definite impact. I have been diagnosed with neuropathy and radiculopathy and I think cymbalta helps with some of the symptoms from this.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 315 patient evaluations for Duloxetine