What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,631 2,703
Depressed mood 1,910 1,070
Major Depressive Disorder 1,510 908
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 681 365
Generalized Anxiety Disorder 678 483
Pain 511 288

Show all 338 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 824
Moderate 869
Mild 1,004
None 1,432

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 256
Weight gain 247
Dizziness 154
Sex drive (libido) decreased 153
Dry mouth 140
Sweating increased 98

Show all 693 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 402
30 mg daily 174
120 mg daily 92
90 mg daily 75
60 mg twice daily 71
20 mg daily 57
30 mg twice daily 40
40 mg daily 28
120 mg twice daily 19
40 mg twice daily 6

See all 47 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1624
Did not seem to work 1389
Doctor's advice 522
Expense 420
Other 393
Personal research 150
Change in health plan coverage 148
Course of treatment ended 63
See all 3159 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 4
1 - 6 months 84
6 months - 1 year 122
1 - 2 years 177
2 - 5 years 274
5 - 10 years 275
10 years or more 116

Stopped taking Duloxetine

Duration Patients
Less than 1 month 685
1 - 6 months 918
6 months - 1 year 513
1 - 2 years 451
2 - 5 years 457
5 - 10 years 123
10 years or more 28
Adherence
Adherence Evaluations
Always 3476
Usually 363
Sometimes 61
Never taken as prescribed 229
Burden
Burden Evaluations
Very hard to take 255
Somewhat hard to take 322
A little hard to take 493
Not at all hard to take 3059
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 176
$50-99 402
$25-49 619
< $25 1276
Not specified 1540

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 105
Fluoxetine (Prozac) 79
Venlafaxine (Effexor XR) 77
Sertraline (Zoloft) 68
Citalopram (Celexa) 59

Show all 60 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 48
Venlafaxine (Effexor XR) 48
Gabapentin (Neurontin) 31
Bupropion (Wellbutrin XL) 27
Sertraline (Zoloft) 25

Show all 63 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,325 members have decided to share their profiles only with other members of PatientsLikeMe.

MakeMeWell
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MakeMeWell
Gender: F
Data Quality: 1 star
Pain: Most
Fatigue: Most
Sleep: Some
Stiffness: Some
function: Some
external_stress: Some
Stickman: some
Description:F59y
FM:16y Dx
I am: g
I have:
Fibromyalgia

See MakeMeWell's full Duloxetine history

Jan 22, 2012 (Started Jul 15, 2009)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 90 mg Daily
Advice & Tips: I was told to take this medication in the morning instead of at night. After a day or two, I started having strange and weird dreams. They were vivid and scary at times. I would find myself falling out of bed. I fell out of bed several nights that week. I finally got tired of doing that and returned back to taking it at night. The bad dreams stopped and so did the falling out of bed.
Cost: $25-49 monthly

  • 0 helpful marks
Aztek350
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Aztek350
Gender: F
Data Quality: 1 star
Depression: 2
Mania: 0
Emotional: 1
Anxiety: 0
Compulsion: 1
External Stress: Low
61 F
Function: High
Distress: Low
I am: g
I have:
Persistent depressive disorder (dysthymia)

See Aztek350's full Duloxetine history

Jan 22, 2012 (Started Jul 01, 2010)

  • Effectiveness
    Moderate (for Persistent depressive disorder (dysthymia))
  • Side effects
    Mild (Constipation)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Ladywolf319
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Ladywolf319
Data Quality: 1 star
  • Gender: F
  • Age: 32
Condition: CRPS II 29 additional condition(s)
Quality of life:
  • Mental: Mild
  • Physical: Moderate
I am: vb
I have:
CRPS II

See Ladywolf319's full Duloxetine history

Jan 20, 2012 (Started Dec 09, 2010)

  • Effectiveness
    None (for Fibromyalgia)
  • Effectiveness
    None (for Depressed mood)
  • Effectiveness
    Moderate (for Generalized Anxiety Disorder)
  • Effectiveness
    Slight (for Major Depressive Disorder)
  • Effectiveness
    None (for Pain in upper back)
  • Effectiveness
    None (for Pain in lower abdomen)
  • Side effects
    Mild (Weight gain, Fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 27, 2011 (Started Dec 09, 2010)

  • Effectiveness
    Can’t tell (for Fibromyalgia)
  • Effectiveness
    None (for Depressed mood)
  • Effectiveness
    Can’t tell (for Generalized Anxiety Disorder)
  • Effectiveness
    None (for Major Depressive Disorder)
  • Effectiveness
    Can’t tell (for Pain in upper back)
  • Effectiveness
    None (for Pain in lower abdomen)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine