What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
fibromyalgia 6,013 3,002
Depressed mood 1,979 1,133
major depressive disorder 1,727 1,054
generalized anxiety disorder 748 528
myalgic encephalomyelitis/chronic fatigue syndrome 691 375
Pain 520 296

Show all 352 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 884
Moderate 952
Mild 1,093
None 1,615

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 291
Nausea 281
Dizziness 158
Dry mouth 156
Sex drive (libido) decreased 155
Sweating increased 99

Show all 725 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 553
30 mg daily 217
120 mg daily 134
90 mg daily 108
60 mg twice daily 97
20 mg daily 85
30 mg twice daily 59
40 mg daily 39
120 mg twice daily 23
20 mg twice daily 13

See all 57 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1678
Did not seem to work 1463
Doctor's advice 550
Expense 433
Other 411
Personal research 165
Change in health plan coverage 153
Course of treatment ended 65
See all 3309 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 2
1 - 6 months 96
6 months - 1 year 211
1 - 2 years 266
2 - 5 years 390
5 - 10 years 362
10 years or more 144

Stopped taking Duloxetine

Duration Patients
Less than 1 month 715
1 - 6 months 943
6 months - 1 year 540
1 - 2 years 473
2 - 5 years 488
5 - 10 years 134
10 years or more 32
Adherence
Adherence Evaluations
Always 3817
Usually 398
Sometimes 67
Never taken as prescribed 262
Burden
Burden Evaluations
Very hard to take 283
Somewhat hard to take 350
A little hard to take 534
Not at all hard to take 3377
Cost per month
Cost per month Evaluations
$200+ 122
$100-199 188
$50-99 422
$25-49 659
< $25 1452
Not specified 1701

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 131
Fluoxetine (Prozac) 105
Venlafaxine (Effexor XR) 99
Sertraline (Zoloft) 86
Citalopram (Celexa) 79

Show all 70 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 66
Venlafaxine (Effexor XR) 56
Gabapentin (Neurontin) 44
Bupropion (Wellbutrin XL) 32
Sertraline (Zoloft) 31

Show all 69 treatments patients report switching to

Last updated:

315 patient evaluations for Duloxetine

Tulabee
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Tulabee
Sex: F
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See Tulabee's full Duloxetine history

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Can’t tell (for Parkinson's disease)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

  • 0 helpful marks
Chrismh1
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Chrismh1
Gender: M
Data Quality: 3 stars
Depression: 4
Mania: 1
Emotional: 3
Anxiety: 4
Compulsion: 3
External Stress: Severe
45 M
Function: Low
Distress: High
I am: vb
I have:
bipolar I disorder

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for postpartum depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
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a-non-mouse
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
Last updated:
Showing 3 of 315 patient evaluations for Duloxetine