What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,185 3,117
Depressed mood 2,026 1,176
Major depressive disorder 1,818 1,105
Generalized anxiety disorder 780 544
Myalgic encephalomyelitis/chronic fatigue syndrome 695 381
Pain 525 305

Show all 315 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 904
Moderate 987
Mild 1,118
None 1,684

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 305
Nausea 281
Dry mouth 161
Dizziness 155
Sex drive (libido) decreased 151
Sweating increased 100

Show all 727 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 419
30 mg daily 161
120 mg daily 121
90 mg daily 78
60 mg twice daily 74
20 mg daily 59
30 mg twice daily 39
40 mg daily 29
20 mg twice daily 17
120 mg twice daily 16

See all 45 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1712
Did not seem to work 1503
Doctor's advice 568
Expense 443
Other 420
Personal research 168
Change in health plan coverage 158
Course of treatment ended 68
See all 3391 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 3
1 - 6 months 76
6 months - 1 year 95
1 - 2 years 178
2 - 5 years 330
5 - 10 years 303
10 years or more 122

Stopped taking Duloxetine

Duration Patients
Less than 1 month 738
1 - 6 months 955
6 months - 1 year 553
1 - 2 years 483
2 - 5 years 501
5 - 10 years 145
10 years or more 33
Adherence
Adherence Evaluations
Always 3939
Usually 413
Sometimes 68
Never taken as prescribed 273
Burden
Burden Evaluations
Very hard to take 296
Somewhat hard to take 359
A little hard to take 545
Not at all hard to take 3493
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 190
$50-99 429
$25-49 677
< $25 1513
Not specified 1758

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 151
Fluoxetine (Prozac) 117
Venlafaxine (Effexor XR) 113
Sertraline (Zoloft) 93
Citalopram (Celexa) 90

Show all 71 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 75
Venlafaxine (Effexor XR) 63
Gabapentin (Neurontin) 54
Sertraline (Zoloft) 35
Bupropion (Wellbutrin XL) 33

Show all 74 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Sep 30, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: The Psych Dr recommended adding 30mg Cymbalta later in the day when the 60 mg dose is used up. Not sure if and when I wil dose up to 120 mg.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Can’t tell (for Parkinson's disease)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (excessive daytime sleepiness (somnolence), sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

  • 0 helpful marks

Jul 2, 2017 (Started Jan 18, 2017)

  • Effectiveness
    Slight (for pain)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Moderate (lack of motivation)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 60 mg Daily

  • 0 helpful marks

Jun 17, 2017 (Started Feb 23, 2017)

  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    Moderate (dizziness, tremor(s))
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 30 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine