What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,268 3,154
Depressed mood 2,044 1,188
Major depressive disorder 1,845 1,121
Generalized anxiety disorder 785 550
Myalgic encephalomyelitis/chronic fatigue syndrome 697 386
Pain 529 308

Show all 314 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
916
Moderate
998
Mild
1,127
None
1,708

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 313
Nausea 284
Dry mouth 163
Dizziness 158
Decreased sex drive (libido) 151
Sweating increased 100

Show all 744 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 431
30 mg daily 170
120 mg daily 123
90 mg daily 83
20 mg daily 72
60 mg twice daily 71
30 mg twice daily 34
40 mg daily 23
20 mg twice daily 16
120 mg twice daily 16

See all 45 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1729
Did not seem to work 1519
Doctor's advice 570
Expense 443
Other 422
Personal research 168
Change in health plan coverage 157
Course of treatment ended 69
See all 3422 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 11
1 - 6 months 88
6 months - 1 year 70
1 - 2 years 169
2 - 5 years 326
5 - 10 years 332
10 years or more 139

Stopped taking Duloxetine

Duration Patients
Less than 1 month 746
1 - 6 months 961
6 months - 1 year 558
1 - 2 years 486
2 - 5 years 505
5 - 10 years 150
10 years or more 33
Adherence
Adherence Evaluations
Always 3980
Usually 419
Sometimes 72
Never taken as prescribed 278
Burden
Burden Evaluations
Very hard to take 296
Somewhat hard to take 364
A little hard to take 550
Not at all hard to take 3539
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 191
$50-99 431
$25-49 685
< $25 1532
Not specified 1784

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 153
Fluoxetine (Prozac) 122
Venlafaxine (Effexor XR) 117
Sertraline (Zoloft) 103
Citalopram (Celexa) 94

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 78
Venlafaxine (Effexor XR) 67
Gabapentin (Neurontin) 57
Sertraline (Zoloft) 35
Bupropion (Wellbutrin XL) 34

Show all 76 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Nov 16, 2017 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Moderate (brain fog)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Severe (brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can’t tell (for Pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Nov 8, 2017 (Started Jul 15, 1996)

  • Effectiveness
    Slight (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Side effects
    Moderate (feelings of hopelessness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: It seems to work. I have been on it so long I cant remember not being on the medication
Cost: < $25 monthly
Side effects: feelings of hopelessness

  • 0 helpful marks

Oct 30, 2017 (Started Dec 01, 2011)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Slight (for degenerative disc disease)
  • Side effects
    Severe (memory problems)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: After several years of taking Cymbalta I noticed some rather significant memory issues. I have no idea if the issues are related to the drug, but I've read other reviews by patients taking Cymbalta, wherein they state exactly the same problem/concerns. Very scary. I was weaned off of Cymbalta with the help of my doctor, who provided nutritional options. It was difficult for the first few months, but then I was fine. However, I recently had surgery on my foot, which left me depressed from being immobile, and in pain from the surgery. I also began to get back the fibro pain. Now I'm wondering if the pain is from the stress of the surgery on my body, or from going off of the nutritional plan (elimination diet) that my doctor had put me on. So it seems I'm going to have to start over one way or another, but am afraid of Cymbalta. Decisions, decisions...
Cost: $25-49 monthly

Jan 25, 2013 (Started Dec 01, 2011)

  • Effectiveness
    Can’t tell (for degenerative disc disease)
  • Effectiveness
    Moderate (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine