What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,299 2,485
Depressed mood 1,865 1,037
Major Depressive Disorder 1,379 809
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 678 358
Generalized Anxiety Disorder 659 470
Pain 503 285

Show all 321 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 775
Moderate 822
Mild 940
None 1,278

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 240
Weight gain 227
Sex drive (libido) decreased 151
Dizziness 145
Dry mouth 128
Sweating increased 97

Show all 655 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 292
30 mg daily 130
120 mg daily 70
90 mg daily 54
60 mg twice daily 39
20 mg daily 37
30 mg twice daily 23
40 mg daily 17
120 mg twice daily 6
20 mg twice daily 5

See all 40 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1571
Did not seem to work 1333
Doctor's advice 509
Expense 412
Other 379
Personal research 148
Change in health plan coverage 141
Course of treatment ended 60
See all 3045 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
1 - 6 months 45
6 months - 1 year 65
1 - 2 years 118
2 - 5 years 199
5 - 10 years 213
10 years or more 78

Stopped taking Duloxetine

Duration Patients
Less than 1 month 645
1 - 6 months 902
6 months - 1 year 491
1 - 2 years 438
2 - 5 years 441
5 - 10 years 118
10 years or more 26
Adherence
Adherence Evaluations
Always 3217
Usually 342
Sometimes 57
Never taken as prescribed 199
Burden
Burden Evaluations
Very hard to take 237
Somewhat hard to take 303
A little hard to take 463
Not at all hard to take 2812
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 170
$50-99 389
$25-49 590
< $25 1128
Not specified 1422

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 73
Venlafaxine (Effexor XR) 61
Fluoxetine (Prozac) 60
Sertraline (Zoloft) 54
Citalopram (Celexa) 47

Show all 55 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 44
Pregabalin (Lyrica) 35
Bupropion (Wellbutrin XL) 24
Gabapentin (Neurontin) 23
Sertraline (Zoloft) 23

Show all 53 treatments patients report switching to

Last updated:

315 patient evaluations for Duloxetine

3,037 members have decided to share their profiles only with other members of PatientsLikeMe.

Chrismh1
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Chrismh1
Gender: M
Data Quality: 3 stars
Depression: 3
Mania: 1
Emotional: 1
Anxiety: 3
Compulsion: 3
External Stress: Severe
45 M
Function: High
Distress: Moderate
I am: vb
I have:
Bipolar I

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
17881 thumb
a-non-mouse
Sex: M
Data Quality: 3 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
ljpwrites
43698 thumb
ljpwrites
Data Quality: 1 star
  • Gender: F
  • Age: 63
Condition: CNS Lupus 10 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Mild
I am: g
I have:
CNS Lupus

See ljpwrites's full Duloxetine history

Oct 22, 2016 (Started Oct 15, 2011)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 60 mg Twice daily
Advice & Tips: If you are hesitant to take any antidepressant because of weight gain or sexual desire issues, try it first.  If it does cause that, you can always be switched to another antidepressant.  There are many, many of these different formulae available to you and your doctor and it might take a while to find the one that is right for you.  Also, internal med MDs and GPs often don't give high enough dosages to be clinically significant (studies show), so if your depression and pain aren't improving, consider a one-time or a short course of visits to a psychiatrist, because they are experts in prescriptions for mental health issues.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 315 patient evaluations for Duloxetine