What is Duloxetine?

Category: Prescription Drugs

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,199 2,399
Depressed mood 1,852 1,026
Major Depressive Disorder 1,346 786
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 679 355
Generalized Anxiety Disorder 653 464
Pain 500 281

Show all 321 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 758
Moderate 810
Mild 913
None 1,233

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 234
Weight gain 220
Sex drive (libido) decreased 151
Dizziness 138
Dry mouth 123
Sweating increased 96

Show all 657 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 257
30 mg daily 113
120 mg daily 65
90 mg daily 47
60 mg twice daily 35
20 mg daily 28
30 mg twice daily 20
40 mg daily 12
120 mg twice daily 5
80 mg daily 3

See all 36 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1553
Did not seem to work 1312
Doctor's advice 503
Expense 410
Other 380
Personal research 146
Change in health plan coverage 142
Course of treatment ended 60
See all 3016 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 6
1 - 6 months 49
6 months - 1 year 39
1 - 2 years 87
2 - 5 years 181
5 - 10 years 200
10 years or more 62

Stopped taking Duloxetine

Duration Patients
Less than 1 month 635
1 - 6 months 900
6 months - 1 year 484
1 - 2 years 432
2 - 5 years 437
5 - 10 years 117
10 years or more 26
Adherence
Adherence Evaluations
Always 3140
Usually 331
Sometimes 55
Never taken as prescribed 188
Burden
Burden Evaluations
Very hard to take 228
Somewhat hard to take 293
A little hard to take 455
Not at all hard to take 2738
Cost per month
Cost per month Evaluations
$200+ 114
$100-199 169
$50-99 386
$25-49 580
< $25 1074
Not specified 1391

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 61
Venlafaxine (Effexor XR) 56
Fluoxetine (Prozac) 52
Escitalopram (Lexapro) 47
Sertraline (Zoloft) 47

Show all 53 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Venlafaxine (Effexor XR) 42
Pregabalin (Lyrica) 30
Bupropion (Wellbutrin XL) 23
Sertraline (Zoloft) 22
Gabapentin (Neurontin) 21

Show all 51 treatments patients report switching to

Last updated:

317 patient evaluations for Duloxetine

2,946 members have decided to share their profiles only with other members of PatientsLikeMe.

Chrismh1
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Chrismh1
Gender: M
Data Quality: 3 stars
Depression: 3
Mania: 1
Emotional: 1
Anxiety: 3
Compulsion: 3
External Stress: Severe
44 M
Function: High
Distress: Moderate
I am: g
I have:
Bipolar I

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
17881 thumb
a-non-mouse
Sex: M
Data Quality: 3 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
ljpwrites
43698 thumb
ljpwrites
Data Quality: 1 star
  • Gender: F
  • Age: 63
Condition: CNS Lupus 10 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Mild
I am: g
I have:
CNS Lupus

See ljpwrites's full Duloxetine history

Oct 22, 2016 (Started Oct 15, 2011)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 60 mg Twice daily
Advice & Tips: If you are hesitant to take any antidepressant because of weight gain or sexual desire issues, try it first.  If it does cause that, you can always be switched to another antidepressant.  There are many, many of these different formulae available to you and your doctor and it might take a while to find the one that is right for you.  Also, internal med MDs and GPs often don't give high enough dosages to be clinically significant (studies show), so if your depression and pain aren't improving, consider a one-time or a short course of visits to a psychiatrist, because they are experts in prescriptions for mental health issues.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 317 patient evaluations for Duloxetine