What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,112 3,075
Depressed mood 2,001 1,150
Major depressive disorder 1,778 1,090
Generalized anxiety disorder 762 537
Myalgic encephalomyelitis/chronic fatigue syndrome 693 380
Pain 524 301

Show all 353 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 899
Moderate 975
Mild 1,111
None 1,659

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 300
Nausea 289
Dizziness 159
Dry mouth 159
Sex drive (libido) decreased 157
Sweating increased 100

Show all 727 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 480
30 mg daily 184
120 mg daily 132
90 mg daily 92
60 mg twice daily 89
20 mg daily 72
30 mg twice daily 49
40 mg daily 31
120 mg twice daily 18
20 mg twice daily 16

See all 50 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1700
Did not seem to work 1492
Doctor's advice 562
Expense 439
Other 418
Personal research 167
Change in health plan coverage 156
Course of treatment ended 66
See all 3366 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 5
1 - 6 months 93
6 months - 1 year 107
1 - 2 years 203
2 - 5 years 393
5 - 10 years 345
10 years or more 140

Stopped taking Duloxetine

Duration Patients
Less than 1 month 728
1 - 6 months 952
6 months - 1 year 552
1 - 2 years 482
2 - 5 years 497
5 - 10 years 139
10 years or more 32
Adherence
Adherence Evaluations
Always 3895
Usually 408
Sometimes 68
Never taken as prescribed 273
Burden
Burden Evaluations
Very hard to take 293
Somewhat hard to take 359
A little hard to take 543
Not at all hard to take 3449
Cost per month
Cost per month Evaluations
$200+ 124
$100-199 187
$50-99 428
$25-49 672
< $25 1489
Not specified 1744

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 147
Fluoxetine (Prozac) 111
Venlafaxine (Effexor XR) 107
Sertraline (Zoloft) 89
Citalopram (Celexa) 88

Show all 70 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 72
Venlafaxine (Effexor XR) 60
Gabapentin (Neurontin) 51
Sertraline (Zoloft) 35
Bupropion (Wellbutrin XL) 32

Show all 70 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Jul 2, 2017 (Started Jan 18, 2017)

  • Effectiveness
    Slight (for Pain)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Lack of motivation)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 60 mg Daily

  • 0 helpful marks

Jun 17, 2017 (Started Feb 23, 2017)

  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    Moderate (Dizziness, Tremor(s))
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 30 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Can’t tell (for Parkinson's disease)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine