What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,340 3,199
Depressed mood 2,077 1,228
Major depressive disorder 1,911 1,159
Generalized anxiety disorder 797 568
Myalgic encephalomyelitis/chronic fatigue syndrome 693 385
Pain 533 316

Show all 326 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 928
Moderate 1,014
Mild 1,144
None 1,765

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 334
Nausea 287
Decreased sex drive (libido) 184
Dry mouth 169
Dizziness 159
Sweating increased 100

Show all 733 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 414
30 mg daily 182
120 mg daily 140
90 mg daily 77
60 mg twice daily 70
20 mg daily 64
30 mg twice daily 26
40 mg daily 16
20 mg twice daily 13
120 mg twice daily 12

See all 43 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1747
Did not seem to work 1546
Doctor's advice 582
Expense 443
Other 434
Personal research 175
Change in health plan coverage 160
Course of treatment ended 69
See all 3479 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 1
1 - 6 months 33
6 months - 1 year 90
1 - 2 years 144
2 - 5 years 307
5 - 10 years 340
10 years or more 168

Stopped taking Duloxetine

Duration Patients
Less than 1 month 814
1 - 6 months 933
6 months - 1 year 548
1 - 2 years 495
2 - 5 years 515
5 - 10 years 155
10 years or more 35
Adherence
Adherence Evaluations
Always 4056
Usually 433
Sometimes 75
Never taken as prescribed 287
Burden
Burden Evaluations
Very hard to take 300
Somewhat hard to take 369
A little hard to take 574
Not at all hard to take 3608
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 191
$50-99 434
$25-49 691
< $25 1559
Not specified 1850

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 129
Venlafaxine (Effexor XR) 123
Sertraline (Zoloft) 111
Citalopram (Celexa) 98

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 77
Venlafaxine (Effexor XR) 69
Gabapentin (Neurontin) 59
Escitalopram (Lexapro) 37
Bupropion (Wellbutrin XL) 36

Show all 77 treatments patients report switching to

Last updated:

321 patient evaluations for Duloxetine

Nov 16, 2017 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    Moderate (brain fog)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    Severe (brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can't tell (for pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Nov 8, 2017 (Started Jul 15, 1996)

  • Effectiveness
    Slight (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Side effects
    Moderate (feelings of hopelessness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: It seems to work. I have been on it so long I cant remember not being on the medication
Cost: < $25 monthly
Side effects: feelings of hopelessness

  • 0 helpful marks

Oct 30, 2017 (Started Dec 01, 2011)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Slight (for degenerative disc disease)
  • Side effects
    Severe (memory problems)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: After several years of taking Cymbalta I noticed some rather significant memory issues. I have no idea if the issues are related to the drug, but I've read other reviews by patients taking Cymbalta, wherein they state exactly the same problem/concerns. Very scary. I was weaned off of Cymbalta with the help of my doctor, who provided nutritional options. It was difficult for the first few months, but then I was fine. However, I recently had surgery on my foot, which left me depressed from being immobile, and in pain from the surgery. I also began to get back the fibro pain. Now I'm wondering if the pain is from the stress of the surgery on my body, or from going off of the nutritional plan (elimination diet) that my doctor had put me on. So it seems I'm going to have to start over one way or another, but am afraid of Cymbalta. Decisions, decisions...
Cost: $25-49 monthly

Jan 25, 2013 (Started Dec 01, 2011)

  • Effectiveness
    Can't tell (for degenerative disc disease)
  • Effectiveness
    Moderate (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 321 patient evaluations for Duloxetine