What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,640 2,711
Depressed mood 1,910 1,070
Major Depressive Disorder 1,512 910
Generalized Anxiety Disorder 681 486
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 681 365
Pain 511 288

Show all 338 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 824
Moderate 871
Mild 1,006
None 1,436

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Nausea 256
Weight gain 248
Dizziness 154
Sex drive (libido) decreased 153
Dry mouth 140
Sweating increased 98

Show all 694 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 405
30 mg daily 175
120 mg daily 94
90 mg daily 75
60 mg twice daily 68
20 mg daily 55
30 mg twice daily 41
40 mg daily 29
120 mg twice daily 20
40 mg twice daily 6

See all 48 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1626
Did not seem to work 1391
Doctor's advice 522
Expense 420
Other 393
Personal research 150
Change in health plan coverage 148
Course of treatment ended 63
See all 3162 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 5
1 - 6 months 85
6 months - 1 year 122
1 - 2 years 178
2 - 5 years 275
5 - 10 years 275
10 years or more 117

Stopped taking Duloxetine

Duration Patients
Less than 1 month 685
1 - 6 months 919
6 months - 1 year 514
1 - 2 years 451
2 - 5 years 458
5 - 10 years 123
10 years or more 28
Adherence
Adherence Evaluations
Always 3483
Usually 363
Sometimes 61
Never taken as prescribed 230
Burden
Burden Evaluations
Very hard to take 256
Somewhat hard to take 322
A little hard to take 493
Not at all hard to take 3066
Cost per month
Cost per month Evaluations
$200+ 116
$100-199 176
$50-99 404
$25-49 619
< $25 1278
Not specified 1544

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 107
Fluoxetine (Prozac) 79
Venlafaxine (Effexor XR) 77
Sertraline (Zoloft) 69
Citalopram (Celexa) 59

Show all 60 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 48
Venlafaxine (Effexor XR) 48
Gabapentin (Neurontin) 31
Bupropion (Wellbutrin XL) 27
Sertraline (Zoloft) 25

Show all 63 treatments patients report switching to

Last updated:

316 patient evaluations for Duloxetine

3,333 members have decided to share their profiles only with other members of PatientsLikeMe.

Chrismh1
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Chrismh1
Gender: M
Data Quality: 2 stars
Depression: 3
Mania: 1
Emotional: 1
Anxiety: 2
Compulsion: 3
External Stress: Low
45 M
Function: Moderate
Distress: Moderate
I am: vb
I have:
Bipolar I

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
17881 thumb
a-non-mouse
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
ljpwrites
43698 thumb
ljpwrites
Data Quality: 1 star
  • Gender: F
  • Age: 63
Condition: CNS Lupus 10 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Mild
I am: g
I have:
CNS Lupus

See ljpwrites's full Duloxetine history

Oct 22, 2016 (Started Oct 15, 2011)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 60 mg Twice daily
Advice & Tips: If you are hesitant to take any antidepressant because of weight gain or sexual desire issues, try it first.  If it does cause that, you can always be switched to another antidepressant.  There are many, many of these different formulae available to you and your doctor and it might take a while to find the one that is right for you.  Also, internal med MDs and GPs often don't give high enough dosages to be clinically significant (studies show), so if your depression and pain aren't improving, consider a one-time or a short course of visits to a psychiatrist, because they are experts in prescriptions for mental health issues.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 316 patient evaluations for Duloxetine