What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,150 3,107
Depressed mood 2,010 1,172
Major depressive disorder 1,789 1,095
Generalized anxiety disorder 767 540
Myalgic encephalomyelitis/chronic fatigue syndrome 692 380
Pain 524 302

Show all 313 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 904
Moderate 980
Mild 1,114
None 1,672

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 302
Nausea 278
Dry mouth 160
Dizziness 155
Decreased sex drive (libido) 151
Sweating increased 100

Show all 728 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 446
30 mg daily 176
120 mg daily 127
90 mg daily 84
60 mg twice daily 77
20 mg daily 69
30 mg twice daily 45
40 mg daily 30
20 mg twice daily 18
120 mg twice daily 18

See all 46 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1709
Did not seem to work 1497
Doctor's advice 566
Expense 443
Other 417
Personal research 168
Change in health plan coverage 158
Course of treatment ended 66
See all 3378 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 3
1 - 6 months 79
6 months - 1 year 105
1 - 2 years 190
2 - 5 years 371
5 - 10 years 321
10 years or more 131

Stopped taking Duloxetine

Duration Patients
Less than 1 month 732
1 - 6 months 955
6 months - 1 year 552
1 - 2 years 482
2 - 5 years 499
5 - 10 years 141
10 years or more 33
Adherence
Adherence Evaluations
Always 3919
Usually 410
Sometimes 68
Never taken as prescribed 273
Burden
Burden Evaluations
Very hard to take 294
Somewhat hard to take 360
A little hard to take 543
Not at all hard to take 3473
Cost per month
Cost per month Evaluations
$200+ 124
$100-199 188
$50-99 428
$25-49 674
< $25 1499
Not specified 1757

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 147
Fluoxetine (Prozac) 115
Venlafaxine (Effexor XR) 110
Sertraline (Zoloft) 93
Citalopram (Celexa) 88

Show all 70 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 75
Venlafaxine (Effexor XR) 60
Gabapentin (Neurontin) 54
Sertraline (Zoloft) 35
Bupropion (Wellbutrin XL) 33

Show all 71 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Jul 2, 2017 (Started Jan 18, 2017)

  • Effectiveness
    Slight (for Pain)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Lack of motivation)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 60 mg Daily

  • 0 helpful marks

Jun 17, 2017 (Started Feb 23, 2017)

  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    Moderate (Dizziness, Tremor(s))
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 30 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Can’t tell (for Parkinson's disease)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine