What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,240 3,138
Depressed mood 2,037 1,185
Major depressive disorder 1,841 1,116
Generalized anxiety disorder 787 548
Myalgic encephalomyelitis/chronic fatigue syndrome 696 385
Pain 527 307

Show all 315 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 914
Moderate 993
Mild 1,125
None 1,698

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 310
Nausea 283
Dry mouth 163
Dizziness 157
Decreased sex drive (libido) 151
Sweating increased 100

Show all 743 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 416
30 mg daily 147
120 mg daily 119
90 mg daily 79
60 mg twice daily 75
20 mg daily 60
30 mg twice daily 33
40 mg daily 24
20 mg twice daily 18
120 mg twice daily 18

See all 43 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1726
Did not seem to work 1512
Doctor's advice 570
Expense 444
Other 422
Personal research 169
Change in health plan coverage 158
Course of treatment ended 68
See all 3414 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 4
1 - 6 months 84
6 months - 1 year 74
1 - 2 years 164
2 - 5 years 318
5 - 10 years 307
10 years or more 127

Stopped taking Duloxetine

Duration Patients
Less than 1 month 744
1 - 6 months 958
6 months - 1 year 557
1 - 2 years 487
2 - 5 years 504
5 - 10 years 148
10 years or more 33
Adherence
Adherence Evaluations
Always 3962
Usually 418
Sometimes 72
Never taken as prescribed 278
Burden
Burden Evaluations
Very hard to take 296
Somewhat hard to take 363
A little hard to take 549
Not at all hard to take 3522
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 190
$50-99 428
$25-49 680
< $25 1527
Not specified 1779

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 153
Fluoxetine (Prozac) 123
Venlafaxine (Effexor XR) 116
Sertraline (Zoloft) 101
Citalopram (Celexa) 92

Show all 73 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 76
Venlafaxine (Effexor XR) 66
Gabapentin (Neurontin) 54
Sertraline (Zoloft) 35
Bupropion (Wellbutrin XL) 34

Show all 74 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Nov 16, 2017 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Moderate (brain fog)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Severe (brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can’t tell (for Pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Nov 8, 2017 (Started Jul 15, 1996)

  • Effectiveness
    Slight (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Side effects
    Moderate (feelings of hopelessness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: It seems to work. I have been on it so long I cant remember not being on the medication
Cost: < $25 monthly
Side effects: feelings of hopelessness

  • 0 helpful marks

Oct 30, 2017 (Started Dec 01, 2011)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Slight (for degenerative disc disease)
  • Side effects
    Severe (memory problems)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: After several years of taking Cymbalta I noticed some rather significant memory issues. I have no idea if the issues are related to the drug, but I've read other reviews by patients taking Cymbalta, wherein they state exactly the same problem/concerns. Very scary. I was weaned off of Cymbalta with the help of my doctor, who provided nutritional options. It was difficult for the first few months, but then I was fine. However, I recently had surgery on my foot, which left me depressed from being immobile, and in pain from the surgery. I also began to get back the fibro pain. Now I'm wondering if the pain is from the stress of the surgery on my body, or from going off of the nutritional plan (elimination diet) that my doctor had put me on. So it seems I'm going to have to start over one way or another, but am afraid of Cymbalta. Decisions, decisions...
Cost: $25-49 monthly

Jan 25, 2013 (Started Dec 01, 2011)

  • Effectiveness
    Can’t tell (for degenerative disc disease)
  • Effectiveness
    Moderate (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine