What is Fampridine (4-AP immediate release)?

Category: Prescription Drugs

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Fampridine, also known as by its chemical name 4-aminopyridine or 4-AP, a potassium channel blocker that is used to improve walking in patients with Multiple Sclerosis. Fampridine is an immediate release formulation of 4-AP that is compounded by pharmacist.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Improve mobility 26 22
Weakness in legs 9 13
Multiple Sclerosis 5 7
Walking problems 5 3
Balance problems 3 8
Stiffness/Spasticity 3 1

Show all 14 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 0
Moderate 5
Mild 13
None 20

Commonly reported side effects and conditions associated with Fampridine (4-AP immediate release)

Side effect Patients
Balance problems 1
Bladder pain 1
Bowel Irregularity 1
Chills 1
Headaches 1
Head Tingling 1

Show all 16 reported side effects

Dosages

Based on patients currently taking Fampridine (4-AP immediate release)

Dosage Patients
30 mg daily 2
10 mg daily 1
15 mg daily 1
20 mg daily 1
22.5 mg daily 1

Why patients stopped taking Fampridine (4-AP immediate release)

Multiple reasons could be selected

Reason Patients
Did not seem to work 7
Other 7
Course of treatment ended 3
Side effects too severe 1
See all 18 patients who’ve stopped taking Fampridine (4-AP immediate release)

Duration

Currently taking Fampridine (4-AP immediate release)

Duration Patients
2 - 5 years 2
5 - 10 years 4

Stopped taking Fampridine (4-AP immediate release)

Duration Patients
Less than 1 month 1
1 - 6 months 7
6 months - 1 year 2
1 - 2 years 4
2 - 5 years 3
10 years or more 1
Adherence
Adherence Evaluations
Always 31
Usually 3
Sometimes 2
Never taken as prescribed 2
Burden
Burden Evaluations
Very hard to take 0
Somewhat hard to take 3
A little hard to take 8
Not at all hard to take 27
Cost per month
Cost per month Evaluations
$200+ 4
$100-199 1
$50-99 11
$25-49 10
< $25 5
Not specified 7

What people switch to and from

Patients stopped taking Fampridine (4-AP immediate release) and switched to:

Treatment Patients
Dalfampridine (Ampyra) 2
Last updated:

1 patient evaluation for Fampridine (4-AP immediate release)

23 members have decided to share their profiles only with other members of PatientsLikeMe.

wysiwyg
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wysiwyg
Sex: F
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: moderate
Vision: moderate
Speech: mild
Swallowing: mild
Upper limb: mild
Walking: moderate
I am: n
I have:
MS

See wysiwyg's full Fampridine (4-AP immediate release) history

Feb 5, 2011 (Started Aug 01, 2007)

  • Effectiveness
    Major (for Other)
  • Side effects
    Mild (Irritation in back of throat)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: The study is now over...and the drug has been renamed Ampyra. During the week between the end of the study and when I received my first "real" prescription, I had no drug...within 3 days, I was having real trouble walking, and/or lifting my feel to get in car, etc. This may or may not have had to do with the Ampyra...at that time my BIL, who had just been diagnosed with ALS was visiting and I was pretty upset, but trying not to show it. After I re-started the drug, within 2-3 days my walking was MUCH better, although, that was in early Aug. 2010 and I am now definitely a wall-walker, and even must use my cane in the house a lot. Getting up and down the stairs is becoming a real chore.
Cost: < $25 monthly
Side effects: Irritation in back of throat

Jun 25, 2010 (Started Aug 01, 2007)

  • Effectiveness
    Slight (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Daily
Advice & Tips: Don't really notice a difference...but when I take timed walking tests, my speed is always the same or a little faster...unless I'm having a "bad" day. I haven't really noticed much difference, but dont' want to quit unless I can't afford it. I was in trials and have been getting drug free, but might have to pay $1000 a month starting soon, as it was just approved by FDA...If so, will definitely quit!
Side effects: Irritation in back of throat

Jan 12, 2009 (Started Aug 01, 2007)

  • Effectiveness
    None (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Daily
Advice & Tips: Not sure this is really doing anything much for me. I'm participating in a study.
Side effects: Irritation in back of throat

  • 0 helpful marks
Last updated:
Showing 1 of 1 patient evaluation for Fampridine (4-AP immediate release)