What is Buprenorphine-Naloxone?

Category: Prescription Drugs

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This is a combination of two medications, buprenorphine and naloxone used to treat opiate drug addiction and withdrawal. Buprenorphine binds to parts of the brain to lower the need for pain drugs and help with withdrawal signs, while naloxone helps prevent abuse of this drug.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Pain 39 17
Fibromyalgia 15 9
Drug use disorder 11 8
Substance abuse 4 0
Back pain 3 1

Show all 23 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 4
Moderate 14
Mild 11
None 14

Commonly reported side effects and conditions associated with Buprenorphine-Naloxone

Side effect Patients
Constipation 7
Decreased sex drive (libido) 5
Headaches 3
Bad taste in mouth 2
Chronic constipation 2
Fatigue 2

Show all 26 reported side effects

Dosages

Based on patients currently taking Buprenorphine-Naloxone

Dosage Patients
8-2 mg twice daily 5
8-2 mg daily 3
2 x 8-2 mg daily 3
0.5 mg twice daily 1
2-0.5 mg daily 1
8-2 mg every other day 1
2-0.5 mg three times daily 1
4-1 mg twice daily 1
4.05 mg twice daily 1
8-2 mg three times daily 1

See all 13 dosages

Why patients stopped taking Buprenorphine-Naloxone

Multiple reasons could be selected

Reason Patients
Other 6
Doctor's advice 4
Course of treatment ended 2
Expense 2
Side effects too severe 2
Personal research 1
See all 12 patients who've stopped taking Buprenorphine-Naloxone

Duration

Currently taking Buprenorphine-Naloxone

Duration Patients
1 - 6 months 3
6 months - 1 year 2
1 - 2 years 4
2 - 5 years 10
5 - 10 years 2

Stopped taking Buprenorphine-Naloxone

Duration Patients
Less than 1 month 2
1 - 6 months 1
6 months - 1 year 2
1 - 2 years 3
2 - 5 years 4
Adherence
Adherence Evaluations
Always 32
Usually 9
Sometimes 2
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 4
Somewhat hard to take 6
A little hard to take 8
Not at all hard to take 25
Cost per month
Cost per month Evaluations
$200+ 10
$100-199 1
$50-99 9
$25-49 5
< $25 10
Not specified 8

What people switch to and from

Patients started taking Buprenorphine-Naloxone after stopping:

Treatment Patients
Methadone (Methadose) 7
Hydrocodone-Acetaminophen (Norco) 4
Oxycodone-acetaminophen (Percocet) 4
Hydromorphone (Dilaudid) 2
Buprenorphine patch (BuTrans patch) 1

Show all 14 treatments patients report switching from

Patients stopped taking Buprenorphine-Naloxone and switched to:

Treatment Patients
Hydromorphone (Dilaudid) 2
Methadone (Methadose) 2
Buprenorphine patch (BuTrans patch) 1
Oxymorphone (Opana ER) 1
Last updated:

3 patient evaluations for Buprenorphine-Naloxone

Sep 28, 2011 (Started Oct 15, 2010)

  • Effectiveness
    Major (for drug use disorder)
  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Cost: $50-99 monthly

Sep 12, 2011 (Started Oct 15, 2010)

  • Effectiveness
    Major (for drug use disorder)
  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    Moderate
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 1 mg Daily
Advice & Tips: This a very good medicine for treating opiate addiction. Works especially well for me because I can't feel a thing from it except for the first dose. It takes away every bit of craving by adhering to those opiate receptors and not letting go for a long time. Yes it is a partial opiate agonist like any dope is - but I don't know of any opiate that reliably removes craving like this one. Methadone is slightly similar but sub is in a league of its own. Suboxone is painfully expensive and in most places impossible to find. There is a vague set of rules that doctors who prescribe suboxone are required to adhere to. Mainly the doctor must do frequent urine tests (to make sure you are taking it and nothing else). You must be in some sort of treatment at the same time as you're taking it. Most Suboxone doctors take advantage of this by requiring the patient to attend some sort of expensive counseling or treatment that the doctors then profit from. Then there are the 12-step groups. Going to these blantantly religious cult meetings with my little paper and having it signed to bring back to the physician proved to be too much for me. I WOULD MUCH RATHER BE STRUNG OUT, ADDICTED, AND UNHEALTY than to attend these things. Demeaning, insulting, useless and mind-numbingly boring are a few words I would use to describe this process. It's too bad that this useful medicine is not available or affordable for the vast majority of people who need it. It's too bad that the hoops one must jump through to continue this therapy as long as is needed will wear one down so quickly.
Cost: $50-99 monthly

Feb 1, 2011 (Started Oct 15, 2010)

  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 8 mg-2 mg Daily
Advice & Tips: This drug is helping with the pain from a broken heel 5 yrs ago. It is hard to have to pretend I am in a twelve-step program when I really am not. I would like to get off of this medicine some time in the near future.
Cost: $50-99 monthly

  • 0 helpful marks

Mar 1, 2009 (Started Mar 01, 2009)

  • Effectiveness
    Major (for Stops craving for opiates but works for pain)
  • Effectiveness
    Major (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 8 mg-2 mg Daily
Advice & Tips: Although it is not FDA approved for pain, it works. I started taking it because I am a recovering opiate addict and low and behold it helped manage my fibro. pain significantly. The benefits are huge, I can go about my daily activities without severe pain where as before it was impossible. The impact this medication has had on my life is great it is helping 2 afflictions w/ one type of medication. I could not take Lyrica as it almost killed me. It put me in hospital and MD's had me diagnosed as possible heart, kidney or liver failure due to extreme swelling in lower extremities.
Cost: < $25 monthly

  • 1 helpful mark

Feb 10, 2009 (Started Aug 15, 2007)

  • Effectiveness
    Moderate (for back pain)
  • Side effects
    Mild (decreased sex drive (libido), constipation)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 8 mg-2 mg Daily
Cost: $25-49 monthly
Side effects: constipation, decreased sex drive (libido), decreased sex drive (libido)

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Buprenorphine-Naloxone