What is sodium hyaluronate?

Sodium hyaluronate is similar to the synovial (sin-OH-vee-ul) fluid that surrounds your joints. Synovial fluid acts as a lubricant and shock absorber.

Sodium hyaluronate is injected into the knee joint to treat pain caused by osteoarthritis. This medication is usually reserved for people whose pain has not been relieved by using other medicines or treatments.

Sodium hyaluronate may also be used for purposes other than those listed in this medication guide.


You should not receive sodium hyaluronate if you have:

  • an infection of your knee joint; or
  • infection of the skin around your knee.

Before receiving sodium hyaluronate, tell your doctor if you have an allergy to eggs, birds, or bird products.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether sodium hyaluronate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

For the first 48 hours after your injection, avoid any strenuous or weight-bearing activity that lasts longer than 1 hour. This includes jogging, tennis, stair-climbing, or lifting weights. Follow your doctor’s instructions about other activity restrictions.

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Seek emergency medical attention if you think you have received too much of this medicine. An overdose of sodium hyaluronate is not expected to produce life-threatening symptoms.

Contact your doctor for instructions if you miss an appointment for your injection.

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Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Other less serious side effects are more likely to occur, such as:

  • pain or swelling where the medicine was injected;
  • joint pain;
  • headache;
  • numbness or tingly feeing;
  • skin irritation; or
  • knee pain or tenderness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

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There may be other drugs that can affect sodium hyaluronate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Euflexxa, Supartz, hyaluronic acid, sodium hyaluronate, and Hyalgan

Available Strengths & Dosages

Route Form Strength
intra-articular solution 10 mg/mL

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Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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