What is Lubiprostone?

Category: Prescription Drugs

Most popular types: Amitiza

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Lubiprostone is a gastrointestinal agent used for the treatment of chronic idiopathic constipation; treatment of irritable bowel syndrome with constipation in adult women.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Constipation 92 58
Bowel problems 29 20
Bowel irritability 27 18
Irritable bowel syndrome 16 8
Chronic constipation 4 0
Gastroparesis 2 2

Show all 18 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 3
Moderate 12
Mild 25
None 42

Commonly reported side effects and conditions associated with Lubiprostone

Side effect Patients
Diarrhea 8
Nausea 5
Abdominal bloating 3
Loose bowel movements 2
Abdominal cramps 1
Abdominal pain 1

Show all 19 reported side effects

Dosages

Based on patients currently taking Lubiprostone

Dosage Patients
24 mcg twice daily 8
16 mcg daily 2
24 mcg daily 2
8 mcg daily 1
12 mcg daily 1
16 mcg twice daily 1
48 mcg daily 1
2 8mcg as needed 1

Why patients stopped taking Lubiprostone

Multiple reasons could be selected

Reason Patients
Other 14
Did not seem to work 13
Side effects too severe 11
Doctor's advice 9
Expense 8
Change in health plan coverage 2
Course of treatment ended 2
Personal research 1
See all 42 patients who've stopped taking Lubiprostone

Duration

Currently taking Lubiprostone

Duration Patients
1 - 6 months 1
6 months - 1 year 1
1 - 2 years 4
2 - 5 years 5
5 - 10 years 2
10 years or more 4

Stopped taking Lubiprostone

Duration Patients
Less than 1 month 11
1 - 6 months 9
6 months - 1 year 6
1 - 2 years 10
2 - 5 years 2
5 - 10 years 3
10 years or more 1
Adherence
Adherence Evaluations
Always 55
Usually 13
Sometimes 11
Never taken as prescribed 3
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 6
A little hard to take 14
Not at all hard to take 61
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 2
$50-99 8
$25-49 16
< $25 24
Not specified 32

What people switch to and from

Patients started taking Lubiprostone after stopping:

Treatment Patients
Linaclotide (Linzess) 5
Polyethylene Glycol 3350 (MiraLax) 3
Dicyclomine (Bentyl) 1
Hydrocortisone suppositories (Anucort HC) 1
Lactulose (Generlac) 1

Show all 8 treatments patients report switching from

Patients stopped taking Lubiprostone and switched to:

Treatment Patients
Polyethylene Glycol 3350 (MiraLax) 2
Lactulose (Generlac) 1
Linaclotide (Linzess) 1
Naloxegol (Movantik) 1
Trazodone (Desyrel) 1
Last updated:

4 patient evaluations for Lubiprostone

Mar 8, 2017 (Started Nov 08, 2011)

  • Effectiveness
    Slight (for constipation)
  • Effectiveness
    Moderate (for bowel problems)
  • Effectiveness
    Slight (for bowel irritability)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 48 mcg Daily
Cost: < $25 monthly

  • 0 helpful marks

Dec 10, 2013 (Started Mar 15, 2013)

  • Effectiveness
    Moderate (for bowel irritability)
  • Effectiveness
    Slight (for constipation)
  • Effectiveness
    Moderate (for irritable bowel syndrome)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 16 mcg Daily
Advice & Tips: take miralax or ducolase sodium
Cost: $50-99 monthly

  • 0 helpful marks

Oct 28, 2012 (Started Mar 01, 2012)

  • Effectiveness
    Moderate (for constipation)
  • Side effects
    Severe (shortness of breath with little or minimal activity (ie standing))
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: As needed

Apr 19, 2012 (Started Mar 01, 2012)

  • Effectiveness
    Moderate (for constipation)
  • Side effects
    Moderate (shortness of breath with little or minimal activity (ie standing))
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: I take Amitza when I am constipated, but it hurts, so I rarely take it. The first time I took it, I had sever shortness of breath and tightness of chest, my cheeks became flushed, and I actually threw it up. I did have a bowel movement with a few hours, but it wasn't worth the pain. I have since tried taking it at different times of the day, with or without food, etc., but I still don't like it.

  • 0 helpful marks
Last updated:
Showing 3 of 4 patient evaluations for Lubiprostone