What is ALS Phase 3 Study Dexpramipexole (KNS-760704)?

Category: Others

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See also: Clinical Trial

NCT01281189 is a randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of dexpramipexole in subjects with amyotrophic lateral sclerosis (ALS). Dexpramipexole was previously known as KNS-760704. Other study IDs: EMPOWER, 223AS302, EUDRA CT NO:2010-022818-19.

Side effects

Side effects as an overall problem

Side effects of ALS Phase 3 Study Dexpramipexole (KNS-760704)

Severe
1
Moderate
2
Mild
9
None
25

Commonly reported side effects, conditions, and hospitalizations associated with ALS Phase 3 Study Dexpramipexole (KNS-760704)

Patients
3
Patients
2
Hospitalization
Patients
2
Patients
2
Patients
2

Show all 21 reported side effects

Dosages

Most common dosages (by patients currently using ALS Phase 3 Study Dexpramipexole (KNS-760704))
Dosage
300 mg daily
Patients
16
Dosage
2 daily
Patients
7
Dosage
2 other daily
Patients
3
Dosage
1M,W,F as needed
Patients
1
Dosage
2 intl units daily
Patients
1
Dosage
2 mg daily
Patients
1
Dosage
30 mg daily
Patients
1
Dosage
150 mg daily
Patients
1
Why Patients Stopped Using ALS Phase 3 Study Dexpramipexole (KNS-760704) (multiple reasons could be selected)
Reason
Course of treatment ended
Patients
13
Reason
Other
Patients
10
Reason
Did not seem to work
Patients
4
Reason
Side effects too severe
Patients
3
Reason
Doctor's advice
Patients
2
Reason
Personal research
Patients
1
See all 27 patients who’ve stopped using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration

Currently Using ALS Phase 3 Study Dexpramipexole (KNS-760704)
Duration
Patients
Duration
0-1 month
Patients
0
Duration
1-3 months
Patients
0
Duration
3-6 months
Patients
0
Duration
6 months-1 year
Patients
0
Duration
1-2 years
Patients
0
Duration
2 years or more
Patients
3
Stopped Using ALS Phase 3 Study Dexpramipexole (KNS-760704)
Duration
Patients
Duration
0-1 month
Patients
1
Duration
1-3 months
Patients
0
Duration
3-6 months
Patients
0
Duration
6 months-1 year
Patients
3
Duration
1-2 years
Patients
20
Duration
2 years or more
Patients
1

Adherence


Always
Patients
35
95%
Usually
Patients
2
5%
Sometimes
Patients
0
0%
Never
Patients
0
0%

Burden


Very
Patients
0
0%
Somewhat
Patients
0
0%
A little
Patients
7
19%
Not at all
Patients
30
81%

Cost per month


Cost per month
$200+
Patients
8
28%
Cost per month
$100-199
Patients
0
0%
Cost per month
$50-99
Patients
1
3%
Cost per month
$25-49
Patients
1
3%
Cost per month
< $25
Patients
0
0%
Cost per month
Not specified
Patients
27
93%
Last updated:

6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)

jaws-als
35884 thumb
jaws-als
Sex: M
Data Quality: 1 star
Bulbar: severe
Arms: severe
Chest: severe
Legs: severe
I am: vg
I have:
ALS

See jaws-als's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Mar 26, 2012 (Started Jul 05, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 300 mg Daily
Cost: Not specified monthly

Jul 20, 2011 (Started Jul 05, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 300 mg Daily
Cost: Not specified monthly

  • 5 helpful marks
Spodfather
35867 thumb
Spodfather
Sex: M
Data Quality: 1 star
Bulbar: mild
Arms: severe
Chest: mild
Legs: moderate
I am: n
I have:
ALS

See Spodfather's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Sep 7, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): None
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Advice & Tips: Struggling to believe this is doing anything for me in terms of slowing progression, if anything its as though its sped up! maybe i'm on the dummy drug.
Cost: Not specified monthly
Side effects: Sleep problems

Aug 23, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Cost: Not specified monthly
Side effects: Sleep problems

Aug 9, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Advice & Tips: This may be a result of Dex or may not but since the i started 2 months ago my breath test improved from 86 to 93! either way it gave me a lift.
Cost: Not specified monthly
Side effects: Sleep problems

Jun 14, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Advice & Tips: The only side effects i have noticed is a change in my sleeping and slightly more indegestion
Cost: Not specified monthly
Side effects: Sleep problems

  • 4 helpful marks
jadedjohn
37652 thumb
jadedjohn
Sex: M
Data Quality: 1 star
Bulbar: mild
Arms: moderate
Chest: none
Legs: moderate
I am: vb
I have:
ALS

See jadedjohn's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Jan 31, 2012 (Started Sep 09, 2011)

  • Perceived effectiveness for Participate in clinical trial: None
  • Side Effects: None
  • Adherence: Always
  • Burden: A little
Dosage: 300 mg Daily
Cost: $50-99 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)