What is ALS Phase 3 Study Dexpramipexole (KNS-760704)?

Category: Others

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See also: Clinical Trial

NCT01281189 is a randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of dexpramipexole in subjects with amyotrophic lateral sclerosis (ALS). Dexpramipexole was previously known as KNS-760704. Other study IDs: EMPOWER, 223AS302, EUDRA CT NO:2010-022818-19.

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 1
Moderate 2
Mild 9
None 25

Commonly reported side effects and conditions associated with ALS Phase 3 Study Dexpramipexole (KNS-760704)

Side effect Patients
Nausea 3
Heartburn 2
Insomnia 2
Neutropenia (low neutrophils) 2
Oily facial skin 2
Abdominal cramps 1

Show all 20 reported side effects

Dosages

Based on patients currently using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Dosage Patients
2 daily 1
2 other daily 1
300 mg daily 1

Why patients stopped taking ALS Phase 3 Study Dexpramipexole (KNS-760704)

Multiple reasons could be selected

Reason Patients
Course of treatment ended 13
Other 10
Did not seem to work 4
Side effects too severe 3
Doctor's advice 2
Personal research 1
See all 25 patients who’ve stopped using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration

Currently using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration Patients
2 years or more 3

Stopped using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration Patients
0-1 month 1
6 months-1 year 3
1-2 years 20
2 years or more 1

Adherence


Always
Patients
35
95%
Usually
Patients
2
5%
Sometimes
Patients
0
0%
Never taken as prescribed
Patients
0
0%

Burden


Very hard to take
Patients
0
0%
Somewhat hard to take
Patients
0
0%
A little hard to take
Patients
7
19%
Not at all hard to take
Patients
30
81%

Cost per month


Cost per month
$200+
Patients
0
0%
Cost per month
$100-199
Patients
1
3%
Cost per month
$50-99
Patients
1
3%
Cost per month
$25-49
Patients
0
0%
Cost per month
< $25
Patients
27
73%
Cost per month
Not specified
Patients
8
22%
Last updated:

6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)

jaws-als
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jaws-als
Sex: M
Data Quality: 1 star
Bulbar: severe
Arms: severe
Chest: severe
Legs: severe
I am: vg
I have:
ALS

See jaws-als's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Mar 26, 2012 (Started Jul 05, 2011)

  • Effectiveness
    Can’t tell (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Cost: < $25 monthly

Jul 20, 2011 (Started Jul 05, 2011)

  • Effectiveness
    Can’t tell (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Cost: < $25 monthly

  • 5 helpful marks
Spodfather
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Spodfather
Sex: M
Data Quality: 1 star
Bulbar: mild
Arms: severe
Chest: mild
Legs: moderate
I am: n
I have:
ALS

See Spodfather's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Sep 7, 2011 (Started Jun 14, 2011)

  • Effectiveness
    None (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    Mild (Sleep problems)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Advice & Tips: Struggling to believe this is doing anything for me in terms of slowing progression, if anything its as though its sped up! maybe i'm on the dummy drug.
Cost: < $25 monthly
Side effects: Sleep problems

Aug 23, 2011 (Started Jun 14, 2011)

  • Effectiveness
    Can’t tell (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    Mild (Sleep problems)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Cost: < $25 monthly
Side effects: Sleep problems

Aug 9, 2011 (Started Jun 14, 2011)

  • Effectiveness
    Can’t tell (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    Mild (Sleep problems)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Advice & Tips: This may be a result of Dex or may not but since the i started 2 months ago my breath test improved from 86 to 93! either way it gave me a lift.
Cost: < $25 monthly
Side effects: Sleep problems

Jun 14, 2011 (Started Jun 14, 2011)

  • Effectiveness
    Can’t tell (for ALS (Amyotrophic Lateral Sclerosis))
  • side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Advice & Tips: The only side effects i have noticed is a change in my sleeping and slightly more indegestion
Cost: < $25 monthly
Side effects: Sleep problems

  • 4 helpful marks
jadedjohn
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jadedjohn
Sex: M
Data Quality: 1 star
Bulbar: mild
Arms: moderate
Chest: none
Legs: moderate
I am: vb
I have:
ALS

See jadedjohn's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Jan 31, 2012 (Started Sep 09, 2011)

  • Effectiveness
    None (for Participate in clinical trial)
  • side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg Daily
Cost: $100-199 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)