What is ALS Phase 3 Study Dexpramipexole (KNS-760704)?

Category: Others

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See also: Clinical Trial

NCT01281189 is a randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of dexpramipexole in subjects with amyotrophic lateral sclerosis (ALS). Dexpramipexole was previously known as KNS-760704. Other study IDs: EMPOWER, 223AS302, EUDRA CT NO:2010-022818-19.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Amyotrophic lateral sclerosis 38 99
Participate in clinical trial 17 21
Increase effect of another treatment 2 14
Arthritis pain in shoulder joints 1 0

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 4
Moderate 4
Mild 28
None 69

Commonly reported side effects and conditions associated with ALS Phase 3 Study Dexpramipexole (KNS-760704)

Side effect Patients
Nausea 3
Heartburn 2
Insomnia 2
Neutropenia (low neutrophils) 2
Oily facial skin 2
Burning sensation in eyes 1

Show all 18 reported side effects

Dosages

Based on patients currently using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Dosage Patients
2 daily 1
300 mg daily 1

Why patients stopped taking ALS Phase 3 Study Dexpramipexole (KNS-760704)

Multiple reasons could be selected

Reason Patients
Course of treatment ended 12
Other 10
Did not seem to work 4
Side effects too severe 3
Doctor's advice 2
Personal research 1
See all 24 patients who've stopped using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration

Currently using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration Patients
5 - 10 years 2

Stopped using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration Patients
Less than 1 month 1
6 months - 1 year 3
1 - 2 years 19
2 - 5 years 1
Adherence
Adherence Evaluations
Always 101
Usually 4
Sometimes 0
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 0
Somewhat hard to take 2
A little hard to take 13
Not at all hard to take 90
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 1
$50-99 1
$25-49 2
< $25 85
Not specified 16
Last updated:

6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)

Mar 26, 2012 (Started Jul 05, 2011)

  • Effectiveness
    Can’t tell (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Cost: < $25 monthly

Jul 20, 2011 (Started Jul 05, 2011)

  • Effectiveness
    Can’t tell (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Cost: < $25 monthly

  • 5 helpful marks

Sep 7, 2011 (Started Jun 14, 2011)

  • Effectiveness
    None (for amyotrophic lateral sclerosis)
  • Side effects
    Mild (Sleep problems)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Advice & Tips: Struggling to believe this is doing anything for me in terms of slowing progression, if anything its as though its sped up! maybe i'm on the dummy drug.
Cost: < $25 monthly
Side effects: Sleep problems

Aug 23, 2011 (Started Jun 14, 2011)

  • Effectiveness
    Can’t tell (for amyotrophic lateral sclerosis)
  • Side effects
    Mild (Sleep problems)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Cost: < $25 monthly
Side effects: Sleep problems

Aug 9, 2011 (Started Jun 14, 2011)

  • Effectiveness
    Can’t tell (for amyotrophic lateral sclerosis)
  • Side effects
    Mild (Sleep problems)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Advice & Tips: This may be a result of Dex or may not but since the i started 2 months ago my breath test improved from 86 to 93! either way it gave me a lift.
Cost: < $25 monthly
Side effects: Sleep problems

Jun 14, 2011 (Started Jun 14, 2011)

  • Effectiveness
    Can’t tell (for amyotrophic lateral sclerosis)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 Daily
Advice & Tips: The only side effects i have noticed is a change in my sleeping and slightly more indegestion
Cost: < $25 monthly
Side effects: Sleep problems

  • 4 helpful marks

Jan 31, 2012 (Started Sep 09, 2011)

  • Effectiveness
    None (for Participate in clinical trial)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg Daily
Cost: $100-199 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)