What is SAMe (S-adenosyl-L-methionine)?

Category: Supplements

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S-adenosyl-L-methionine (SAMe) is an amino acid. As a supplement it's use is promoted for depression, osteoarthritis, and cholestasis of pregnancy and intrahepatic cholestasis associated with liver disease.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 38 22
Fibromyalgia 19 11
General health 10 4
Amyotrophic lateral sclerosis 4 3
Anxious mood 4 3

Show all 47 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 7
Moderate 7
Mild 8
None 44

Commonly reported side effects and conditions associated with SAMe (S-adenosyl-L-methionine)

Side effect Patients
Stomach pain 3
Headaches 2
Anxious mood 1
Bipolar manic episodes 1
Depressed mood 1
Dizziness with nausea 1

Show all 20 reported side effects

Dosages

Based on patients currently taking SAMe (S-adenosyl-L-methionine)

Dosage Patients
400 mg daily 4
200 mg daily 2
800 mg daily 2
200 mg three times daily 1
600 mg daily 1
400 mg twice daily 1
400 mg three times daily 1
400mg as needed 1

Why patients stopped taking SAMe (S-adenosyl-L-methionine)

Multiple reasons could be selected

Reason Patients
Did not seem to work 17
Expense 16
Other 16
Side effects too severe 11
Doctor's advice 3
Personal research 3
Course of treatment ended 2
See all 50 patients who've stopped taking SAMe (S-adenosyl-L-methionine)

Duration

Currently taking SAMe (S-adenosyl-L-methionine)

Duration Patients
1 - 6 months 2
6 months - 1 year 2
1 - 2 years 3
2 - 5 years 2
5 - 10 years 2
10 years or more 2

Stopped taking SAMe (S-adenosyl-L-methionine)

Duration Patients
Less than 1 month 13
1 - 6 months 22
6 months - 1 year 9
1 - 2 years 2
2 - 5 years 3
5 - 10 years 1
Adherence
Adherence Evaluations
Always 48
Usually 15
Sometimes 3
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 4
Somewhat hard to take 8
A little hard to take 16
Not at all hard to take 38
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 0
$50-99 7
$25-49 25
< $25 11
Not specified 23
Last updated:

7 patient evaluations for SAMe (S-adenosyl-L-methionine)

Jan 17, 2012 (Started Dec 23, 2011)

  • Effectiveness
    None (for Treat my mood condition(s))
  • Side effects
    Mild (depressed mood)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: I think SAMe has some good background but personally I felt like I was slipping into a depressed state, so I have stopped taking this andstuck to the 5-HTP

  • 0 helpful marks

Jun 20, 2011 (Started Mar 15, 2011)

  • Effectiveness
    Can't tell (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Jun 14, 2010 (Started Aug 24, 2009)

  • Effectiveness
    Slight (for Joint health)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 400 mg Daily
Advice & Tips: Felt was beneficial overall; stopped due to lack of funds--see comments for St. John's Wort.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 7 patient evaluations for SAMe (S-adenosyl-L-methionine)