What is 5-methyltetrahydrofolate (5-MTHF)?

Category: Supplements

Most popular types: FolaPro

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5-MTHF is an acronym for 5-methyltetrahydrofolate, also known as L-5-methyltetrahydrofolate (L-5-MTHF). It is the metabolically active form of folic acid that plays a role in DNA synthesis and repair.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Methylenetetrahydrofolate reductase deficiency 8 4
Folic acid deficiency 5 5
Fibromyalgia 2 1
Major depressive disorder 2 2
Amyotrophic lateral sclerosis 1 0
Depressed mood 1 0

Show all 9 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 0
Moderate 0
Mild 0
None 11

Commonly reported side effects and conditions associated with 5-methyltetrahydrofolate (5-MTHF)

Side effect Patients

Dosages

Based on patients currently taking 5-methyltetrahydrofolate (5-MTHF)

Dosage Patients
400 mcg daily 2
5 mg daily 1
10 mg daily 1
25 mg daily 1
350 mcg daily 1

Why patients stopped taking 5-methyltetrahydrofolate (5-MTHF)

Multiple reasons could be selected

Reason Patients
Did not seem to work 4
Expense 4
Course of treatment ended 2
Doctor's advice 1
Other 1
See all 8 patients who've stopped taking 5-methyltetrahydrofolate (5-MTHF)

Duration

Currently taking 5-methyltetrahydrofolate (5-MTHF)

Duration Patients
1 - 2 years 1
2 - 5 years 3
5 - 10 years 2

Stopped taking 5-methyltetrahydrofolate (5-MTHF)

Duration Patients
Less than 1 month 1
1 - 6 months 3
6 months - 1 year 1
1 - 2 years 1
2 - 5 years 2
Adherence
Adherence Evaluations
Always 8
Usually 3
Sometimes 0
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 0
Somewhat hard to take 0
A little hard to take 1
Not at all hard to take 10
Cost per month
Cost per month Evaluations
$200+ 0
$100-199 1
$50-99 2
$25-49 2
< $25 3
Not specified 3
Last updated:

2 patient evaluations for 5-methyltetrahydrofolate (5-MTHF)

Oct 27, 2013 (Started Oct 15, 2013)

  • Effectiveness
    Moderate (for methylenetetrahydrofolate reductase deficiency)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 5 mg Daily

  • 0 helpful marks

Aug 14, 2012 (Started Jan 01, 2012)

  • Effectiveness
    Major (for Methylation)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 350 mcg Daily
Advice & Tips: In patients afflicted with Fibromyalgia and Chronic Fatigue Syndrome, the methionine synthase reaction is partially blocked, therefore Folic acid (Methylfolate) cannot be converted to folinic acid. Without Methylation, the body is unable to produce vital substances like Glutathione, Methionine, etc., which in turn stifles vital functions, such as detoxification of Heavy metals like Mercury, etc. The Methylation Protocol at: <http://www.fightingfatigue.org/?p=8994>
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 2 of 2 patient evaluations for 5-methyltetrahydrofolate (5-MTHF)