What is Amitriptyline?

Category: Prescription Drugs

Most popular types: Elavil Endep Trepiline Show all

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Amitriptyline is a tricyclic antidepressant approved for the treatment of depression. Off label amitripyline is used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 969 598
Fibromyalgia 913 521
Pain 858 524
Depressed mood 193 111
Sleep problems 152 83
Migraine headaches 148 97

Show all 307 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 246
Moderate 362
Mild 464
None 588

Commonly reported side effects and conditions associated with Amitriptyline

Side effect Patients
Dry mouth 155
Weight gain 97
Drowsiness 69
Sleepiness 50
Excessive daytime sleepiness (somnolence) 47
Grogginess 44

Show all 308 reported side effects

Dosages

Based on patients currently taking Amitriptyline

Dosage Patients
25 mg daily 71
50 mg daily 71
10 mg daily 55
100 mg daily 31
20 mg daily 24
75 mg daily 24
30 mg daily 13
150 mg daily 9
10 mg twice daily 4
25 mg twice daily 4

See all 29 dosages

Why patients stopped taking Amitriptyline

Multiple reasons could be selected

Reason Patients
Did not seem to work 438
Side effects too severe 432
Doctor's advice 236
Other 158
Course of treatment ended 51
Personal research 50
Expense 15
Change in health plan coverage 9
See all 1027 patients who’ve stopped taking Amitriptyline

Duration

Currently taking Amitriptyline

Duration Patients
1 - 6 months 24
6 months - 1 year 20
1 - 2 years 46
2 - 5 years 114
5 - 10 years 74
10 years or more 63

Stopped taking Amitriptyline

Duration Patients
Less than 1 month 183
1 - 6 months 288
6 months - 1 year 172
1 - 2 years 140
2 - 5 years 159
5 - 10 years 56
10 years or more 35
Adherence
Adherence Evaluations
Always 1324
Usually 211
Sometimes 67
Never taken as prescribed 58
Burden
Burden Evaluations
Very hard to take 76
Somewhat hard to take 109
A little hard to take 218
Not at all hard to take 1257
Cost per month
Cost per month Evaluations
$200+ 6
$100-199 3
$50-99 8
$25-49 36
< $25 855
Not specified 752

What people switch to and from

Patients started taking Amitriptyline after stopping:

Treatment Patients
Gabapentin (Neurontin) 11
Duloxetine (Cymbalta) 8
Trazodone (Desyrel) 5
Pregabalin (Lyrica) 4
Topiramate (Topamax) 4

Show all 46 treatments patients report switching from

Patients stopped taking Amitriptyline and switched to:

Treatment Patients
Nortriptyline (Pamelor) 19
Gabapentin (Neurontin) 17
Pregabalin (Lyrica) 13
Duloxetine (Cymbalta) 9
Topiramate (Topamax) 6

Show all 45 treatments patients report switching to

Last updated:

153 patient evaluations for Amitriptyline

1,196 members have decided to share their profiles only with other members of PatientsLikeMe.

sheronemus
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sheronemus
Sex: M
Data Quality: 2 stars
Bulbar: moderate
Arms: severe
Chest: moderate
Legs: moderate
I am: vg
I have:
ALS

See sheronemus's full Amitriptyline history

Oct 10, 2016 (Started Jul 01, 2009)

  • Effectiveness
    Moderate (for Excess saliva)
  • Side effects
    Mild (Drowsiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily

  • 0 helpful marks
jasminefaery
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jasminefaery
Gender: F
Data Quality: 3 stars
Depression: 1
Mania: 0
Emotional: 0
Anxiety: 1
Compulsion: 0
External Stress: Low
54 F
Function: High
Distress: Low
I am: g
I have:
Major Depressive Disorder

See jasminefaery's full Amitriptyline history

Aug 2, 2016 (Started Apr 19, 2012)

  • Effectiveness
    Moderate (for Major Depressive Disorder)
  • Side effects
    Mild (Weight gain, Fluid retention weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Elavil is becoming unfamiliar with psychiatrists these days; they seem to feel that the old tricylics don't work as well as all the SSRI's that are out there now. Personally, over the vast amount of years with my psychiatrist, we tried everything from A-Z......always came back to Elavil. The SSRI's had terrible side effects & did not work as well. I think it's been quite effective! The weight gain used to be bad until I was dxed w/ Type 2 Diabetes (not on medication/just diet & exercise & glucose monitoring daily) Now I've been losing weight.
Cost: < $25 monthly

  • 0 helpful marks
janik
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janik
Sex: F
Data Quality: 3 stars
Bulbar: mild
Arms: moderate
Chest: none
Legs: moderate
I am: n
I have:
PLS

See janik's full Amitriptyline history

Jul 20, 2016 (Started Apr 13, 1998)

  • Effectiveness
    Slight (for Pain)
  • Effectiveness
    Can’t tell (for Nerve damage)
  • Side effects
    Moderate (Occasional constipation, Mucous membrane dryness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Advice & Tips: unexpected benefit in reduced drippy nose in the morning and throughout the day from allergies.
Cost: < $25 monthly
Side effects: Dry mouth

Oct 22, 2015 (Started Apr 13, 1998)

  • Effectiveness
    Can’t tell (for Pain)
  • Effectiveness
    Can’t tell (for Nerve damage)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Cost: < $25 monthly
Side effects: Dry mouth

Feb 20, 2001 (Started Apr 13, 1998)

  • Effectiveness
    Slight (for Pain)
  • Side effects
    Mild (Occasional constipation, Mucous membrane dryness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Cost: < $25 monthly
Side effects: Dry mouth

  • 0 helpful marks
Last updated:
Showing 3 of 153 patient evaluations for Amitriptyline