What is Amitriptyline?

Category: Prescription Drugs

Most popular types: Elavil Endep Trepiline Show all

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See also: Amantadine-amitriptyline-baclofen-clonidine-lidocaine-nifedipine-prilocaine

Amitriptyline is a tricyclic antidepressant used for the treatment of depression. It may also be used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 1,037 680
Fibromyalgia 965 582
Pain 904 584
Depressed mood 206 121
Migraine headaches 166 108

Show all 307 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 273
Moderate 397
Mild 526
None 672

Commonly reported side effects and conditions associated with Amitriptyline

Side effect Patients
Dry mouth 178
Weight gain 106
Drowsiness 81
Sleepiness 57
Excessive daytime sleepiness (somnolence) 50
Grogginess 46

Show all 327 reported side effects

Dosages

Based on patients currently taking Amitriptyline

Dosage Patients
25 mg daily 86
50 mg daily 76
10 mg daily 60
100 mg daily 33
20 mg daily 27
30 mg daily 22
75 mg daily 19
150 mg daily 7
200 mg daily 5
25 mg twice daily 4

See all 43 dosages

Why patients stopped taking Amitriptyline

Multiple reasons could be selected

Reason Patients
Did not seem to work 474
Side effects too severe 464
Doctor's advice 257
Other 173
Course of treatment ended 57
Personal research 53
Expense 15
Change in health plan coverage 11
See all 1103 patients who've stopped taking Amitriptyline

Duration

Currently taking Amitriptyline

Duration Patients
Less than 1 month 1
1 - 6 months 19
6 months - 1 year 36
1 - 2 years 51
2 - 5 years 119
5 - 10 years 86
10 years or more 72

Stopped taking Amitriptyline

Duration Patients
Less than 1 month 198
1 - 6 months 306
6 months - 1 year 179
1 - 2 years 147
2 - 5 years 177
5 - 10 years 62
10 years or more 39
Adherence
Adherence Evaluations
Always 1494
Usually 225
Sometimes 73
Never taken as prescribed 76
Burden
Burden Evaluations
Very hard to take 86
Somewhat hard to take 119
A little hard to take 239
Not at all hard to take 1424
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 3
$50-99 10
$25-49 40
< $25 970
Not specified 838

What people switch to and from

Patients started taking Amitriptyline after stopping:

Treatment Patients
Gabapentin (Neurontin) 14
Duloxetine (Cymbalta) 13
Trazodone (Desyrel) 9
Zolpidem (Ambien) 9
Topiramate (Topamax) 7

Show all 65 treatments patients report switching from

Patients stopped taking Amitriptyline and switched to:

Treatment Patients
Nortriptyline (Pamelor) 25
Gabapentin (Neurontin) 22
Duloxetine (Cymbalta) 14
Pregabalin (Lyrica) 14
Trazodone (Desyrel) 9

Show all 53 treatments patients report switching to

Last updated:

154 patient evaluations for Amitriptyline

Jul 22, 2017 (Started Jul 01, 2002)

  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Slight (for pain)
  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Cost: < $25 monthly

Dec 31, 2011 (Started Jul 01, 2002)

  • Effectiveness
    Slight (for insomnia)
  • Effectiveness
    Slight (for fibromyalgia)
  • Effectiveness
    Slight (for pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Advice & Tips: This definitely helps with the problems I have sleeping, getting to sleep, staying asleep, getting restorative sleep, depression, and pain. I can tell more when I miss 2 or more nights, usually caused by a refill problem. I try to never run out and have to go without a dose. Missing doses causes all my problems like with sleeping, pain, and depression to become worse and my other medications don't seem as effective. I really take a nose dive if more than 2 doses are missed. Missing only 1 is tolerable, missing anymore becomes a big problem. I get anxious, teary, sleepless, and I feel hopeless. It is a horrible feeling.
Cost: < $25 monthly

  • 0 helpful marks

Jul 2, 2017 (Started Jan 15, 2016)

  • Effectiveness
    Slight (for peripheral neuropathy)
  • Side effects
    Moderate (mood swings, drowsiness)
  • Adherence
    Usually
  • Burden
    Very hard to take
Dosage: 50 mg Daily
Advice & Tips: The best way to take is at night otherwise i have found that day to day function can be very difficult
Cost: < $25 monthly

  • 0 helpful marks

May 19, 2017 (Started May 05, 2017)

  • Effectiveness
    Slight (for neuropathy in hands)
  • Effectiveness
    Moderate (for neuropathy in feet)
  • Side effects
    Moderate (drunk feeling, migraine headaches, nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

  • 0 helpful marks
Last updated:
Showing 3 of 154 patient evaluations for Amitriptyline