What is Sirolimus?

Category: Prescription Drugs

Most popular types: Rapamune Rocas

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Sirolimus is an immunosuppressant agent used to prevent organ rejection in renal transplants, in combination with corticosteroids and cyclosporine. It is also used to prevent rejection in heart transplant and for immunosuppression for stem cell/bone marrow transplants.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Prevent organ rejection 93 21
Kidney transplant 7 2
Heart transplant 2 0
Lymphangiomatosis 2 2
Liver transplant 1 1

Show all 10 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 10
Moderate 10
Mild 6
None 7

Commonly reported side effects and conditions associated with Sirolimus

Side effect Patients
Acne breakout 3
Chronic diarrhea 3
Mouth sores (ulcers) 3
Fluid retention (edema) 2
Increased lipids in blood (hyperlipidemia) 2
Swelling in lower extremities 2

Show all 23 reported side effects

Dosages

Based on patients currently taking Sirolimus

Dosage Patients
2 mg daily 2
1 mg m,w,f 1
0.5 mg daily 1
1 mg twice daily 1
2.5 mg daily 1
4 mg daily 1
1mg as needed 1

Why patients stopped taking Sirolimus

Multiple reasons could be selected

Reason Patients
Doctor's advice 15
Side effects too severe 14
Did not seem to work 4
Personal research 3
Other 2
Course of treatment ended 1
See all 25 patients who've stopped taking Sirolimus

Duration

Currently taking Sirolimus

Duration Patients
1 - 2 years 1
2 - 5 years 1
5 - 10 years 4
10 years or more 2

Stopped taking Sirolimus

Duration Patients
Less than 1 month 7
1 - 6 months 9
6 months - 1 year 4
1 - 2 years 1
2 - 5 years 2
5 - 10 years 2
Adherence
Adherence Evaluations
Always 29
Usually 4
Sometimes 0
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 1
Somewhat hard to take 5
A little hard to take 2
Not at all hard to take 25
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 1
$50-99 4
$25-49 1
< $25 7
Not specified 19

What people switch to and from

Patients started taking Sirolimus after stopping:

Treatment Patients
Tacrolimus (Prograf) 2
Belimumab (Benlysta) 1
Cyclosporine (Neoral) 1

Patients stopped taking Sirolimus and switched to:

Treatment Patients
Mycophenolic acid (Myfortic) 1
Last updated:

3 patient evaluations for Sirolimus

Jun 17, 2012 (Started Jul 18, 2011)

  • Effectiveness
    Can't tell (for Prevent organ rejection)
  • Side effects
    Moderate (swelling in lower extremities)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 0.5 mg Daily
Side effects: swelling in lower extremities

  • 0 helpful marks

Jul 14, 2010 (Started Jul 21, 1998)

  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Severe (recurrent hernias)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 mg Daily
Advice & Tips: This drug does cause hernias anywhere you have previously been operated on...except of course your knee or foot... I don't mind taking this drug in fact I feel I need it so I won't reject my sisters kidney, since we only shared 1 antigen out of 6...I'm taking care of this kidney and if this is the drug I need to keep it, then I 'll just continue to have my hernias repaired...I've had 8 hernia surgeries to my abdomine and kidney sight in the last 10 yrs...it's been painful and I now have 3 new hernias...I can't lift anything over 10lbs, or bend excessively with out tearing myself...I constantly have to ask friends and neighbors to help me around the house, even carrying in the groceries...I'm sure one of the reasons my ex hubby found a younger woman was so he could scuba dive with her...I can't carry the tanks...and I'm sure he got sick of the surgeries and helping me as well...oh well, win some and lose some...
Cost: $200+ monthly
Side effects: recurrent hernias

  • 0 helpful marks

Mar 17, 2010 (Started Dec 17, 2003)

  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Moderate (swelling in feet)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 mg Daily
Advice & Tips: It was a replacement drug for Prograf which I could not tolerate.
Side effects: swelling in feet

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Sirolimus