What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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See also: Methotrexate-Vinblastine-Doxorubicin-Cisplatin (MVAC)

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1,548 612
Systemic lupus erythematosus 308 138
Psoriatic arthritis 210 103
Psoriasis 185 84
Multiple sclerosis 72 39

Show all 121 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 222
Moderate 306
Mild 259
None 254

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 252
Fatigue 121
Hair loss 92
Headaches 56
Nausea and vomiting 43
Mouth sores (ulcers) 42

Show all 309 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
20 mg weekly 68
15 mg weekly 58
25 mg weekly 37
10 mg weekly 36
12.5 mg weekly 21
7.5 mg weekly 19
17.5 mg weekly 9
30 mg weekly 9
5 mg weekly 7
2.5 mg weekly 5

See all 58 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 472
Did not seem to work 245
Doctor's advice 235
Other 109
Course of treatment ended 50
Personal research 28
Change in health plan coverage 14
Expense 14
See all 814 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
Less than 1 month 5
1 - 6 months 17
6 months - 1 year 31
1 - 2 years 45
2 - 5 years 85
5 - 10 years 93
10 years or more 55

Stopped taking Methotrexate

Duration Patients
Less than 1 month 129
1 - 6 months 174
6 months - 1 year 154
1 - 2 years 115
2 - 5 years 150
5 - 10 years 58
10 years or more 32
Adherence
Adherence Evaluations
Always 866
Usually 107
Sometimes 16
Never taken as prescribed 52
Burden
Burden Evaluations
Very hard to take 74
Somewhat hard to take 147
A little hard to take 184
Not at all hard to take 636
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 6
$50-99 24
$25-49 47
< $25 504
Not specified 452

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 57
Prednisone (Deltasone) 29
Sulfasalazine (Salazopyrin) 14
Azathioprine (Imuran) 13
Leflunomide (Arava) 9

Show all 45 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Leflunomide (Arava) 35
Azathioprine (Imuran) 21
Etanercept (Enbrel SureClick) 20
Sulfasalazine (Salazopyrin) 18
Adalimumab (Humira) 17

Show all 33 treatments patients report switching to

Last updated:

48 patient evaluations for Methotrexate

May 12, 2018 (Started Feb 03, 2010)

  • Effectiveness
    Can't tell (for chronic inflammatory demyelinating polyneuropathy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for psoriatic arthritis)
  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Mild (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Effectiveness
    Moderate (for Crohn's disease)
  • Side effects
    Moderate (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 48 patient evaluations for Methotrexate