What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Wellbutrin SR Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major Depressive Disorder 1,597 894
Depressed mood 1,475 693
Persistent depressive disorder (dysthymia) 312 265
Mild Depression 132 51
Anxious mood 113 52
Bipolar Disorder 97 81

Show all 203 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 213
Moderate 296
Mild 492
None 843

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 84
Anxious mood 52
Insomnia 44
Weight gain 41
Constipation 38
Headaches 38

Show all 385 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
150 mg daily 83
300 mg daily 77
300 mg/24 hours daily 69
100 mg daily 49
150 mg/24 hours daily 32
450 mg daily 29
75 mg daily 28
100 mg twice daily 28
200 mg daily 22
150 mg twice daily 17

See all 57 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 513
Side effects too severe 441
Doctor's advice 354
Other 241
Expense 76
Course of treatment ended 75
Personal research 62
Change in health plan coverage 34
See all 1296 patients who’ve stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 3
1 - 6 months 25
6 months - 1 year 51
1 - 2 years 92
2 - 5 years 141
5 - 10 years 144
10 years or more 86

Stopped taking Bupropion

Duration Patients
Less than 1 month 249
1 - 6 months 316
6 months - 1 year 198
1 - 2 years 191
2 - 5 years 232
5 - 10 years 105
10 years or more 44
Adherence
Adherence Evaluations
Always 1444
Usually 297
Sometimes 41
Never taken as prescribed 62
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 111
A little hard to take 283
Not at all hard to take 1389
Cost per month
Cost per month Evaluations
$200+ 10
$100-199 22
$50-99 73
$25-49 149
< $25 899
Not specified 691

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 50
Fluoxetine (Prozac) 39
Venlafaxine (Effexor XR) 36
Duloxetine (Cymbalta) 30
Citalopram (Celexa) 23

Show all 36 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 31
Sertraline (Zoloft) 23
Venlafaxine (Effexor XR) 17
Citalopram (Celexa) 15
Bupropion (Wellbutrin XL) 13

Show all 34 treatments patients report switching to

Last updated:

183 patient evaluations for Bupropion

1,383 members have decided to share their profiles only with other members of PatientsLikeMe.

CupcakeKitten
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CupcakeKitten
Gender: F
Data Quality: 3 stars
Depression: 2
Mania: 0
Emotional: 2
Anxiety: 1
Compulsion: 1
External Stress: Moderate
25 F
Function: Moderate
Distress: Low
I am: b
I have:
Borderline Personality

See CupcakeKitten's full Bupropion history

Jan 13, 2017 (Started Dec 06, 2016)

  • Effectiveness
    Slight (for Lack of motivation)
  • Effectiveness
    Slight (for Exhaustion)
  • Effectiveness
    Slight (for Excessive sleeping (hypersomnia))
  • Side effects
    Moderate (Muscle twitching (fasciculations), Impulsive behaviors)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 75 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
ProfGumbySan
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ProfGumbySan
Sex: M
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See ProfGumbySan's full Bupropion history

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks
jackconrad
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jackconrad
Sex: M
Data Quality: 3 stars
Bulbar: none
Arms: moderate
Chest: none
Legs: moderate
I am: n
I have:
ALS

See jackconrad's full Bupropion history

Aug 15, 2016 (Started Aug 12, 2016)

  • Effectiveness
    None (for Mild Depression)
  • Side effects
    Severe (Tiredness increased)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 75 mg Daily
Advice & Tips: wiped me out..
Cost: < $25 monthly

Aug 7, 2016 (Started Aug 12, 2016)

  • Effectiveness
    None (for Mild Depression)
  • Side effects
    Severe
  • Adherence
    Sometimes
  • Burden
    Very hard to take
Advice & Tips: find better..
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 183 patient evaluations for Bupropion