What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Wellbutrin SR Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major Depressive Disorder 1,535 844
Depressed mood 1,466 682
Persistent depressive disorder (dysthymia) 298 245
Mild Depression 131 49
Anxious mood 113 51
Bipolar Disorder 95 79

Show all 201 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 205
Moderate 282
Mild 472
None 813

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 83
Anxious mood 49
Insomnia 44
Constipation 36
Headaches 36
Weight gain 35

Show all 368 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
150 mg daily 76
300 mg/24 hours daily 73
300 mg daily 70
100 mg daily 45
150 mg/24 hours daily 31
75 mg daily 25
450 mg daily 24
150 mg twice daily 21
100 mg twice daily 19
200 mg daily 13

See all 53 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 504
Side effects too severe 424
Doctor's advice 343
Other 239
Course of treatment ended 75
Expense 75
Personal research 62
Change in health plan coverage 34
See all 1271 patients who’ve stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 2
1 - 6 months 33
6 months - 1 year 45
1 - 2 years 74
2 - 5 years 128
5 - 10 years 131
10 years or more 76

Stopped taking Bupropion

Duration Patients
Less than 1 month 240
1 - 6 months 313
6 months - 1 year 197
1 - 2 years 184
2 - 5 years 229
5 - 10 years 103
10 years or more 43
Adherence
Adherence Evaluations
Always 1393
Usually 283
Sometimes 41
Never taken as prescribed 55
Burden
Burden Evaluations
Very hard to take 57
Somewhat hard to take 103
A little hard to take 270
Not at all hard to take 1342
Cost per month
Cost per month Evaluations
$200+ 11
$100-199 21
$50-99 71
$25-49 147
< $25 860
Not specified 662

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 44
Venlafaxine (Effexor XR) 35
Fluoxetine (Prozac) 32
Duloxetine (Cymbalta) 27
Citalopram (Celexa) 19

Show all 35 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 26
Sertraline (Zoloft) 23
Venlafaxine (Effexor XR) 16
Bupropion (Wellbutrin XL) 13
Citalopram (Celexa) 12

Show all 33 treatments patients report switching to

Last updated:

183 patient evaluations for Bupropion

1,325 members have decided to share their profiles only with other members of PatientsLikeMe.

ProfGumbySan
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ProfGumbySan
Sex: M
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See ProfGumbySan's full Bupropion history

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks
jackconrad
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jackconrad
Sex: M
Data Quality: 3 stars
Bulbar: none
Arms: moderate
Chest: none
Legs: moderate
I am: g
I have:
ALS

See jackconrad's full Bupropion history

Aug 7, 2016 (Started Aug 12, 2016)

  • Effectiveness
    None (for Mild Depression)
  • Side effects
    Severe
  • Adherence
    Sometimes
  • Burden
    Very hard to take
Advice & Tips: find better..
Cost: < $25 monthly

  • 0 helpful marks
leejon66
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leejon66
Gender: M
Data Quality: 1 star
Depression: 0
Mania: 1
Emotional: 1
Anxiety: 2
Compulsion: 0
External Stress: Low
68 M
Function: High
Distress: Low
I am: b
I have:
PTSD

See leejon66's full Bupropion history

Aug 5, 2016 (Started Jul 01, 1979)

  • Effectiveness
    Slight (for Major Depressive Disorder)
  • Effectiveness
    Slight (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg One time

Jun 5, 2015 (Started Jul 01, 1979)

  • Effectiveness
    Major (for Major Depressive Disorder)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily
Advice & Tips: you need to talk to your Doctor about this treatment plan. some say it is to expense. I get my medIdecation from the VA

  • 0 helpful marks
Last updated:
Showing 3 of 183 patient evaluations for Bupropion