What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid Arthritis (RA) 1,400 536
Systemic Lupus Erythematosus 229 103
Psoriatic Arthritis 191 88
Psoriasis 181 80
Multiple Sclerosis 73 36
Rheumatoid Arthritis 44 20

Show all 121 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 198
Moderate 264
Mild 227
None 207

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 216
Fatigue 108
Hair loss 81
Nausea and vomiting 43
Headaches 42
Mouth sores (ulcers) 34

Show all 287 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
15 mg weekly 57
20 mg weekly 49
10 mg weekly 34
25 mg weekly 32
7.5 mg weekly 15
12.5 mg weekly 10
17.5 mg weekly 9
30 mg weekly 7
0.6 mg weekly 3
5 mg weekly 3

See all 43 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 409
Did not seem to work 218
Doctor's advice 210
Other 94
Course of treatment ended 44
Personal research 27
Expense 14
Change in health plan coverage 13
See all 706 patients who’ve stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
Less than 1 month 1
1 - 6 months 21
6 months - 1 year 24
1 - 2 years 45
2 - 5 years 68
5 - 10 years 62
10 years or more 42

Stopped taking Methotrexate

Duration Patients
Less than 1 month 102
1 - 6 months 151
6 months - 1 year 147
1 - 2 years 101
2 - 5 years 134
5 - 10 years 43
10 years or more 27
Adherence
Adherence Evaluations
Always 737
Usually 100
Sometimes 14
Never taken as prescribed 45
Burden
Burden Evaluations
Very hard to take 66
Somewhat hard to take 137
A little hard to take 165
Not at all hard to take 528
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 21
$25-49 39
< $25 430
Not specified 392

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 40
Prednisone (Deltasone) 21
Sulfasalazine (Salazopyrin) 10
Azathioprine (Imuran) 8
Mycophenolate mofetil (CellCept) 7

Show all 38 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Azathioprine (Imuran) 17
Leflunomide (Arava) 16
Sulfasalazine (Salazopyrin) 14
Mycophenolate mofetil (CellCept) 12
Etanercept (Enbrel SureClick) 11

Show all 29 treatments patients report switching to

Last updated:

47 patient evaluations for Methotrexate

728 members have decided to share their profiles only with other members of PatientsLikeMe.

Monas21
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Monas21
Data Quality: 2 stars
Age: 58y
Gender:
Condition: Psoriasis
I am: b
BSA% 18
DLQI score: 14
I have:
Psoriasis

See Monas21's full Methotrexate history

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for Psoriasis)
  • Side effects
    Moderate (Upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for Psoriatic Arthritis)
  • Effectiveness
    Moderate (for Psoriasis)
  • Side effects
    Mild (Upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks
CarynH
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CarynH
Data Quality: 1 star
  • Gender: F
  • Age: 44
Condition: Crohn's Disease 7 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Moderate
I am: b
I have:
Crohn's Disease

See CarynH's full Methotrexate history

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for Rheumatoid Arthritis (RA))
  • Effectiveness
    Moderate (for Crohn's Disease)
  • Side effects
    Moderate (Grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
homesick
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homesick
Sex: F
Data Quality: 2 stars
Sensation: Severe
Overall: Moderate
Cognition: moderate
Vision: moderate
Speech: moderate
Swallowing: moderate
Upper limb: moderate
Walking: moderate
I am: b
I have:
MS

See homesick's full Methotrexate history

May 26, 2016 (Started Oct 30, 2007)

  • Effectiveness
    Slight (for Multiple Sclerosis)
  • Effectiveness
    Slight (for Arthritis pain)
  • Side effects
    Mild (Nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 22.5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 47 patient evaluations for Methotrexate