What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
rheumatoid arthritis 1,416 552
systemic lupus erythematosus 242 113
psoriatic arthritis 197 93
psoriasis 183 80
multiple sclerosis 72 36
Rheumatoid Arthritis 44 20

Show all 124 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 202
Moderate 270
Mild 235
None 223

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 225
Fatigue 110
Hair loss 82
Headaches 45
Nausea and vomiting 43
Mouth sores (ulcers) 35

Show all 292 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
15 mg weekly 52
20 mg weekly 47
10 mg weekly 39
25 mg weekly 33
7.5 mg weekly 23
12.5 mg weekly 11
17.5 mg weekly 8
30 mg weekly 5
2.5 mg weekly 4
0.6 mg weekly 3

See all 46 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 415
Did not seem to work 226
Doctor's advice 215
Other 97
Course of treatment ended 45
Personal research 27
Expense 14
Change in health plan coverage 13
See all 723 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
Less than 1 month 1
1 - 6 months 21
6 months - 1 year 21
1 - 2 years 42
2 - 5 years 73
5 - 10 years 73
10 years or more 44

Stopped taking Methotrexate

Duration Patients
Less than 1 month 107
1 - 6 months 156
6 months - 1 year 149
1 - 2 years 104
2 - 5 years 135
5 - 10 years 43
10 years or more 28
Adherence
Adherence Evaluations
Always 767
Usually 102
Sometimes 16
Never taken as prescribed 45
Burden
Burden Evaluations
Very hard to take 69
Somewhat hard to take 139
A little hard to take 170
Not at all hard to take 552
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 22
$25-49 40
< $25 450
Not specified 404

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 42
Prednisone (Deltasone) 21
Sulfasalazine (Salazopyrin) 11
Azathioprine (Imuran) 9
Mycophenolate mofetil (CellCept) 7

Show all 39 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Leflunomide (Arava) 18
Azathioprine (Imuran) 17
Sulfasalazine (Salazopyrin) 16
Mycophenolate mofetil (CellCept) 14
Etanercept (Enbrel SureClick) 12

Show all 30 treatments patients report switching to

Last updated:

47 patient evaluations for Methotrexate

Monas21
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Monas21
Data Quality: 1 star
Age: 58y
Gender:
Condition: Psoriasis
I am: b
BSA% 18
DLQI score: 14
I have:
Psoriasis

See Monas21's full Methotrexate history

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (Upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for psoriatic arthritis)
  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Mild (Upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks
CarynH
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CarynH
Data Quality: 1 star
  • Gender: F
  • Age: 44
Condition: Crohn's disease 7 additional condition(s)
Quality of life:
  • Mental: Moderate
  • Physical: Moderate
I am: n
I have:
Crohn's disease

See CarynH's full Methotrexate history

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Effectiveness
    Moderate (for Crohn's disease)
  • Side effects
    Moderate (Grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
homesick
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homesick
Sex: F
Data Quality: 2 stars
Sensation: Severe
Overall: Moderate
Cognition: moderate
Vision: moderate
Speech: moderate
Swallowing: moderate
Upper limb: moderate
Walking: moderate
I am: b
I have:
MS

See homesick's full Methotrexate history

May 26, 2016 (Started Oct 30, 2007)

  • Effectiveness
    Slight (for multiple sclerosis)
  • Effectiveness
    Slight (for Arthritis pain)
  • Side effects
    Mild (Nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 22.5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 47 patient evaluations for Methotrexate