What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1,465 575
Systemic lupus erythematosus 273 121
Psoriatic arthritis 204 97
Psoriasis 183 80
Multiple sclerosis 71 36

Show all 115 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 216
Moderate 279
Mild 240
None 237

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 232
Fatigue 116
Hair loss 87
Headaches 51
Nausea and vomiting 43
Mouth sores (ulcers) 39

Show all 301 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
15 mg weekly 55
20 mg weekly 41
10 mg weekly 38
25 mg weekly 28
7.5 mg weekly 22
12.5 mg weekly 17
30 mg weekly 7
5 mg weekly 5
17.5 mg weekly 5
0.6 mg weekly 3

See all 46 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 437
Did not seem to work 235
Doctor's advice 225
Other 101
Course of treatment ended 49
Personal research 28
Expense 14
Change in health plan coverage 13
See all 762 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
Less than 1 month 1
1 - 6 months 28
6 months - 1 year 27
1 - 2 years 30
2 - 5 years 69
5 - 10 years 77
10 years or more 43

Stopped taking Methotrexate

Duration Patients
Less than 1 month 114
1 - 6 months 161
6 months - 1 year 157
1 - 2 years 107
2 - 5 years 142
5 - 10 years 48
10 years or more 32
Adherence
Adherence Evaluations
Always 804
Usually 104
Sometimes 16
Never taken as prescribed 48
Burden
Burden Evaluations
Very hard to take 71
Somewhat hard to take 141
A little hard to take 179
Not at all hard to take 581
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 23
$25-49 44
< $25 470
Not specified 421

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 46
Prednisone (Deltasone) 24
Sulfasalazine (Salazopyrin) 13
Azathioprine (Imuran) 10
Mycophenolate mofetil (CellCept) 8

Show all 42 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Leflunomide (Arava) 28
Azathioprine (Imuran) 17
Sulfasalazine (Salazopyrin) 16
Mycophenolate mofetil (CellCept) 15
Adalimumab (Humira) 14

Show all 31 treatments patients report switching to

Last updated:

47 patient evaluations for Methotrexate

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for psoriatic arthritis)
  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Mild (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Effectiveness
    Moderate (for Crohn's disease)
  • Side effects
    Moderate (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks

May 26, 2016 (Started Oct 30, 2007)

  • Effectiveness
    Slight (for multiple sclerosis)
  • Effectiveness
    Slight (for arthritis pain)
  • Side effects
    Mild (nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 22.5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 47 patient evaluations for Methotrexate