What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1,529 602
Systemic lupus erythematosus 300 133
Psoriatic arthritis 209 102
Psoriasis 185 83
Multiple sclerosis 72 37

Show all 119 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 220
Moderate 297
Mild 253
None 248

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 244
Fatigue 117
Hair loss 89
Headaches 53
Nausea and vomiting 43
Mouth sores (ulcers) 42

Show all 307 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
20 mg weekly 71
15 mg weekly 57
25 mg weekly 34
10 mg weekly 31
12.5 mg weekly 24
7.5 mg weekly 19
30 mg weekly 10
5 mg weekly 7
17.5 mg weekly 7
0.6 mL weekly 5

See all 61 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 462
Did not seem to work 243
Doctor's advice 233
Other 106
Course of treatment ended 50
Personal research 28
Change in health plan coverage 14
Expense 14
See all 799 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
1 - 6 months 17
6 months - 1 year 41
1 - 2 years 44
2 - 5 years 91
5 - 10 years 90
10 years or more 58

Stopped taking Methotrexate

Duration Patients
Less than 1 month 128
1 - 6 months 168
6 months - 1 year 152
1 - 2 years 113
2 - 5 years 151
5 - 10 years 54
10 years or more 31
Adherence
Adherence Evaluations
Always 844
Usually 107
Sometimes 16
Never taken as prescribed 51
Burden
Burden Evaluations
Very hard to take 73
Somewhat hard to take 142
A little hard to take 182
Not at all hard to take 621
Cost per month
Cost per month Evaluations
$200+ 8
$100-199 6
$50-99 24
$25-49 46
< $25 495
Not specified 439

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 56
Prednisone (Deltasone) 27
Sulfasalazine (Salazopyrin) 14
Azathioprine (Imuran) 13
Leflunomide (Arava) 8

Show all 44 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Leflunomide (Arava) 34
Azathioprine (Imuran) 21
Etanercept (Enbrel SureClick) 18
Sulfasalazine (Salazopyrin) 18
Adalimumab (Humira) 16

Show all 31 treatments patients report switching to

Last updated:

47 patient evaluations for Methotrexate

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for psoriatic arthritis)
  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Mild (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Effectiveness
    Moderate (for Crohn's disease)
  • Side effects
    Moderate (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks

May 26, 2016 (Started Oct 30, 2007)

  • Effectiveness
    Slight (for multiple sclerosis)
  • Effectiveness
    Slight (for arthritis pain)
  • Side effects
    Mild (nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 22.5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 47 patient evaluations for Methotrexate