What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

false

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1,441 564
Systemic lupus erythematosus 256 118
Psoriatic arthritis 199 94
Psoriasis 183 80
Multiple sclerosis 71 36

Show all 113 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 208
Moderate 276
Mild 237
None 230

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients
Nausea 227
Fatigue 112
Hair loss 85
Headaches 47
Nausea and vomiting 43
Mouth sores (ulcers) 37

Show all 298 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients
15 mg weekly 46
20 mg weekly 41
10 mg weekly 34
7.5 mg weekly 26
25 mg weekly 26
12.5 mg weekly 17
17.5 mg weekly 5
30 mg weekly 5
2.5 mg weekly 4
5 mg weekly 4

See all 42 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients
Side effects too severe 425
Did not seem to work 231
Doctor's advice 221
Other 99
Course of treatment ended 45
Personal research 28
Expense 14
Change in health plan coverage 13
See all 740 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients
Less than 1 month 3
1 - 6 months 27
6 months - 1 year 16
1 - 2 years 27
2 - 5 years 64
5 - 10 years 73
10 years or more 45

Stopped taking Methotrexate

Duration Patients
Less than 1 month 110
1 - 6 months 160
6 months - 1 year 151
1 - 2 years 104
2 - 5 years 137
5 - 10 years 46
10 years or more 31
Adherence
Adherence Evaluations
Always 785
Usually 104
Sometimes 16
Never taken as prescribed 46
Burden
Burden Evaluations
Very hard to take 71
Somewhat hard to take 142
A little hard to take 174
Not at all hard to take 564
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 7
$50-99 23
$25-49 42
< $25 460
Not specified 412

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients
Hydroxychloroquine (Plaquenil) 43
Prednisone (Deltasone) 23
Sulfasalazine (Salazopyrin) 11
Azathioprine (Imuran) 10
Mycophenolate mofetil (CellCept) 7

Show all 40 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients
Leflunomide (Arava) 20
Azathioprine (Imuran) 17
Sulfasalazine (Salazopyrin) 16
Etanercept (Enbrel SureClick) 14
Mycophenolate mofetil (CellCept) 14

Show all 32 treatments patients report switching to

Last updated:

47 patient evaluations for Methotrexate

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (Upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Slight (for psoriatic arthritis)
  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Mild (Upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Effectiveness
    Moderate (for Crohn's disease)
  • Side effects
    Moderate (Grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks

May 26, 2016 (Started Oct 30, 2007)

  • Effectiveness
    Slight (for multiple sclerosis)
  • Effectiveness
    Slight (for Arthritis pain)
  • Side effects
    Mild (Nausea)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 22.5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 47 patient evaluations for Methotrexate