What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6,296 3,168
Depressed mood 2,054 1,203
Major depressive disorder 1,873 1,132
Generalized anxiety disorder 789 552
Myalgic encephalomyelitis/chronic fatigue syndrome 696 386
Pain 534 313

Show all 325 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
921
Moderate
1,002
Mild
1,133
None
1,726

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 315
Nausea 286
Dry mouth 166
Dizziness 158
Decreased sex drive (libido) 153
Sweating increased 100

Show all 747 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 429
30 mg daily 184
120 mg daily 129
90 mg daily 80
60 mg twice daily 73
20 mg daily 64
30 mg twice daily 34
20 mg twice daily 18
40 mg daily 18
120 mg twice daily 15

See all 47 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1739
Did not seem to work 1529
Doctor's advice 578
Expense 444
Other 426
Personal research 168
Change in health plan coverage 159
Course of treatment ended 69
See all 3449 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
1 - 6 months 53
6 months - 1 year 100
1 - 2 years 162
2 - 5 years 331
5 - 10 years 340
10 years or more 148

Stopped taking Duloxetine

Duration Patients
Less than 1 month 809
1 - 6 months 931
6 months - 1 year 542
1 - 2 years 489
2 - 5 years 509
5 - 10 years 153
10 years or more 33
Adherence
Adherence Evaluations
Always 4003
Usually 423
Sometimes 73
Never taken as prescribed 283
Burden
Burden Evaluations
Very hard to take 299
Somewhat hard to take 365
A little hard to take 556
Not at all hard to take 3562
Cost per month
Cost per month Evaluations
$200+ 126
$100-199 191
$50-99 430
$25-49 686
< $25 1546
Not specified 1803

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 152
Fluoxetine (Prozac) 124
Venlafaxine (Effexor XR) 121
Sertraline (Zoloft) 107
Citalopram (Celexa) 95

Show all 74 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 78
Venlafaxine (Effexor XR) 68
Gabapentin (Neurontin) 58
Escitalopram (Lexapro) 36
Sertraline (Zoloft) 36

Show all 77 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Nov 16, 2017 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    Moderate (brain fog)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Jun 20, 2016 (Started Mar 15, 2012)

  • Effectiveness
    Moderate (for pain)
  • Side effects
    Severe (brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

Dec 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Slight (for pain)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: < $25 monthly

Oct 22, 2012 (Started Mar 15, 2012)

  • Effectiveness
    Can't tell (for pain)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Nov 8, 2017 (Started Jul 15, 1996)

  • Effectiveness
    Slight (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for generalized anxiety disorder)
  • Side effects
    Moderate (feelings of hopelessness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: It seems to work. I have been on it so long I cant remember not being on the medication
Cost: < $25 monthly
Side effects: feelings of hopelessness

  • 0 helpful marks

Oct 30, 2017 (Started Dec 01, 2011)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Slight (for degenerative disc disease)
  • Side effects
    Severe (memory problems)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: After several years of taking Cymbalta I noticed some rather significant memory issues. I have no idea if the issues are related to the drug, but I've read other reviews by patients taking Cymbalta, wherein they state exactly the same problem/concerns. Very scary. I was weaned off of Cymbalta with the help of my doctor, who provided nutritional options. It was difficult for the first few months, but then I was fine. However, I recently had surgery on my foot, which left me depressed from being immobile, and in pain from the surgery. I also began to get back the fibro pain. Now I'm wondering if the pain is from the stress of the surgery on my body, or from going off of the nutritional plan (elimination diet) that my doctor had put me on. So it seems I'm going to have to start over one way or another, but am afraid of Cymbalta. Decisions, decisions...
Cost: $25-49 monthly

Jan 25, 2013 (Started Dec 01, 2011)

  • Effectiveness
    Can't tell (for degenerative disc disease)
  • Effectiveness
    Moderate (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine