What is Pyridostigmine?

Category: Prescription Drugs

Most popular types: Mestinon Mestinon Timespan Kalymin 60N

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Pyridostigmine is an acetylcholinesterase inhibitor used for the symptomatic treatment of myaesthenia gravis and as an antidote for nondepolarizing neuromuscular blockers.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Myasthenia gravis 132 70
Fatigue 18 10
Lambert-Eaton myasthenic syndrome 7 1
Postural orthostatic tachycardia syndrome 7 4
Dysautonomia 6 5
Amyotrophic lateral sclerosis 5 1

Show all 58 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 7
Moderate 19
Mild 27
None 48

Commonly reported side effects and conditions associated with Pyridostigmine

Side effect Patients
Diarrhea 18
Nausea 6
Excess saliva 3
Sweating 3
Abdominal cramps 2
Abdominal pain 2

Show all 52 reported side effects

Dosages

Based on patients currently taking Pyridostigmine

Dosage Patients
60 mg three times daily 7
180 mg daily 4
60 mg four times daily 4
30 mg three times daily 3
30 mg daily 2
60 mg daily 2
60 mg twice daily 2
90 mg four times daily 2
120 mg four times daily 2
1 mg twice daily 1

See all 19 dosages

Why patients stopped taking Pyridostigmine

Multiple reasons could be selected

Reason Patients
Did not seem to work 18
Doctor's advice 12
Side effects too severe 11
Other 7
Expense 2
Course of treatment ended 1
See all 35 patients who've stopped taking Pyridostigmine

Duration

Currently taking Pyridostigmine

Duration Patients
1 - 6 months 3
6 months - 1 year 4
1 - 2 years 5
2 - 5 years 17
5 - 10 years 5
10 years or more 2

Stopped taking Pyridostigmine

Duration Patients
Less than 1 month 7
1 - 6 months 9
6 months - 1 year 8
1 - 2 years 4
2 - 5 years 4
5 - 10 years 2
10 years or more 1
Adherence
Adherence Evaluations
Always 68
Usually 22
Sometimes 6
Never taken as prescribed 5
Burden
Burden Evaluations
Very hard to take 6
Somewhat hard to take 7
A little hard to take 17
Not at all hard to take 71
Cost per month
Cost per month Evaluations
$200+ 1
$100-199 1
$50-99 1
$25-49 16
< $25 28
Not specified 54

What people switch to and from

Patients started taking Pyridostigmine after stopping:

Treatment Patients
Meclizine (Antivert) 1
Metoprolol (Metoprolol Tartrate) 1
Prednisone (Deltasone) 1
Senna (Senokot) 1

Patients stopped taking Pyridostigmine and switched to:

Treatment Patients
Droxidopa (Northera) 1
Fludrocortisone (Florinef) 1
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 1
Midodrine (ProAmatine) 1
Last updated:

3 patient evaluations for Pyridostigmine

Mar 1, 2011 (Started Aug 01, 2006)

  • Effectiveness
    None (for fatigue)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks

Apr 8, 2009 (Started Apr 08, 2009)

  • Effectiveness
    Moderate (for Other)
  • Effectiveness
    Moderate (for fatigue)
  • Effectiveness
    None (for double vision (diplopia))
  • Side effects
    Moderate (excess mucus)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 30 mg All the time (24/7)
Advice & Tips: The doctor prescribed way too much for me initially. I was to take 60 mg every four hours, well by the second dose I had 120 mg and I was rigid, weak, could not form words with my mouth and tongue, I sounded like I inhaled helium, my face muscles were not working together....I hyperventilated and my anxiety shot through the roof !A trip to the ER, with several IV's and a re-evaluation over the phone with the doc. I now take 1/2-1 30mg tablet as needed. I am monitoring symptoms...no vision improvement but it does help with speaking, choking and neck pain.
Cost: $50-99 monthly
Side effects: excess mucus

  • 0 helpful marks

Aug 19, 2008 (Started Dec 17, 2005)

  • Effectiveness
    Major (for Other)
  • Effectiveness
    None (for atrophy of upper body muscles)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 180 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Pyridostigmine