What is Carbidopa-Entacapone-Levodopa?

Category: Prescription Drugs

Most popular types: Stalevo Stalevo 100 Stalevo 150 Show all

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The combination of levodopa, carbidopa, and entacapone is used for Parkinson's Disease. Levodopa is the precursor to dopamine, carbidopa slows the breakdown of levodopa, while entacapone improves the efficacy of levodopa.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 629 287
Stiffness/spasticity 21 14
Increase effect of another treatment 14 12
Improve mobility 5 4
Slow movement (bradykinesia) 3 0
Tremor in hands 3 2

Show all 26 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 32
Moderate 67
Mild 74
None 124

Commonly reported side effects and conditions associated with Carbidopa-Entacapone-Levodopa

Side effect Patients
Jerky movements 36
Nausea 15
Cramps in legs 8
Wearing off increased tremors 8
Dry mouth 7
Weight gain 6

Show all 97 reported side effects

Dosages

Based on patients currently taking Carbidopa-Entacapone-Levodopa

Dosage Patients
25 mg-200 mg-100 mg daily 6
3 x 25 mg-200 mg-100 mg daily 6
37.5-200-150 mg four times daily 4
25 mg-200 mg-100 mg four times daily 4
25-200-100 mg four times daily 3
25 mg-200 mg-100 mg five times daily 3
5 x 37.5 mg-200 mg-150 mg daily 3
25-200-100 mg twice daily 2
31.25-200-125 mg three times daily 2
50-200-200 mg twice daily 2

See all 67 dosages

Why patients stopped taking Carbidopa-Entacapone-Levodopa

Multiple reasons could be selected

Reason Patients
Side effects too severe 70
Doctor's advice 64
Did not seem to work 39
Other 33
Expense 21
Personal research 9
Change in health plan coverage 3
Course of treatment ended 1
See all 191 patients who've stopped taking Carbidopa-Entacapone-Levodopa

Duration

Currently taking Carbidopa-Entacapone-Levodopa

Duration Patients
1 - 6 months 4
6 months - 1 year 3
1 - 2 years 6
2 - 5 years 16
5 - 10 years 48
10 years or more 21

Stopped taking Carbidopa-Entacapone-Levodopa

Duration Patients
Less than 1 month 27
1 - 6 months 58
6 months - 1 year 36
1 - 2 years 22
2 - 5 years 47
5 - 10 years 12
10 years or more 3
Adherence
Adherence Evaluations
Always 225
Usually 54
Sometimes 7
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 16
Somewhat hard to take 32
A little hard to take 62
Not at all hard to take 187
Cost per month
Cost per month Evaluations
$200+ 19
$100-199 15
$50-99 29
$25-49 44
< $25 93
Not specified 97

What people switch to and from

Patients started taking Carbidopa-Entacapone-Levodopa after stopping:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 32
Ropinirole (Requip) 8
Carbidopa Levodopa ER (Rytary XR) 3
Amantadine (Symmetrel) 2
Pramipexole (Mirapex) 2

Show all 11 treatments patients report switching from

Patients stopped taking Carbidopa-Entacapone-Levodopa and switched to:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 13
Carbidopa Levodopa ER (Rytary XR) 8
Entacapone (Comtan) 3
Carbidopa-Levodopa CR (Sinemet CR) 2
Pramipexole (Mirapex) 2

Show all 8 treatments patients report switching to

Last updated:

42 patient evaluations for Carbidopa-Entacapone-Levodopa

Mar 26, 2018 (Started Jan 10, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50-200-200 mg Three times daily
Advice & Tips: I take the kind that dissolves in your mouth, because of my emphysema. I take it three times a day at 8am 3pm and 10pm. That works well for me.
Cost: < $25 monthly

Jun 8, 2016 (Started Jan 10, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 50-200-200 mg Three times daily
Cost: < $25 monthly

  • 0 helpful marks

Jun 19, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12.5-200-50 mg Three times daily

  • 0 helpful marks

Jun 13, 2017 (Started May 19, 2017)

  • Effectiveness
    None (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50-200-200 mg Five times daily
Advice & Tips: I have advanced pd. We were hoping it might help me a little bit more than Rytary. It didn't.
Cost: $200+ monthly

Sep 16, 2015 (Started May 19, 2017)

  • Effectiveness
    Can't tell (for stiffness/spasticity)
  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I HAVE BEEN GOING BACK AND FORTH BETWEEN STALEVO AND RYTARY. UNFORTUNATELY, NEITHER SEEM TO BE HELPNG ME.
Cost: $200+ monthly

Apr 13, 2015 (Started May 19, 2017)

  • Effectiveness
    Can't tell (for stiffness/spasticity)
  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I STOPPED STALEVO TO GO ON RYTARY--THE NEW DRUG. I DON'T FEEL LIKE IT HELPED ME AT ALL
Cost: $200+ monthly

  • 0 helpful marks
Last updated:
Showing 3 of 42 patient evaluations for Carbidopa-Entacapone-Levodopa