What is Depakote?

Category: Prescription Drugs

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Generic name: Divalproex sodium

See also: Valproic Acid

Depakote is a brand name for the antiseizure drug Valproate semisodium, used in the treatment of epilepsy, chronic pain associated with neuropathy, migraine headaches, and manic episodes in bipolar disorder.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Bipolar disorder 184 115
Epilepsy 173 90
Migraine headaches 47 36
Bipolar II disorder 28 24
Bipolar manic episodes 19 15
Bipolar I disorder 16 9

Show all 66 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 99
Moderate 83
Mild 75
None 82

Commonly reported side effects and conditions associated with Depakote

Side effect Patients
Weight gain 65
Fatigue 25
Hair loss 22
Drowsiness 12
Grogginess 9
Nausea 9

Show all 110 reported side effects

Dosages

Based on patients currently taking Depakote

Dosage Patients
250 mg twice daily 6
1,000 mg daily 6
500 mg daily 4
750 mg daily 4
500 mg twice daily 4
250 mg daily 3
2,000 mg daily 3
1,500 mg daily 2
500 mg three times daily 2
1,000 mg twice daily 2

See all 22 dosages

Why patients stopped taking Depakote

Multiple reasons could be selected

Reason Patients
Side effects too severe 175
Did not seem to work 108
Doctor's advice 72
Other 45
Personal research 20
Expense 14
Course of treatment ended 10
Change in health plan coverage 5
See all 303 patients who've stopped taking Depakote

Duration

Currently taking Depakote

Duration Patients
1 - 6 months 2
6 months - 1 year 2
1 - 2 years 10
2 - 5 years 12
5 - 10 years 12
10 years or more 12

Stopped taking Depakote

Duration Patients
Less than 1 month 56
1 - 6 months 75
6 months - 1 year 38
1 - 2 years 32
2 - 5 years 59
5 - 10 years 18
10 years or more 25
Adherence
Adherence Evaluations
Always 266
Usually 52
Sometimes 11
Never taken as prescribed 10
Burden
Burden Evaluations
Very hard to take 31
Somewhat hard to take 36
A little hard to take 63
Not at all hard to take 209
Cost per month
Cost per month Evaluations
$200+ 6
$100-199 7
$50-99 14
$25-49 19
< $25 138
Not specified 155

What people switch to and from

Patients started taking Depakote after stopping:

Treatment Patients
Lithium Carbonate (Lithium Carbonate ER) 21
Lamotrigine (Lamictal) 9
Aripiprazole (Abilify) 6
Sertraline (Zoloft) 4
Topiramate (Topamax) 4

Show all 34 treatments patients report switching from

Patients stopped taking Depakote and switched to:

Treatment Patients
Lamotrigine (Lamictal) 19
Lithium Carbonate (Lithium Carbonate ER) 8
Carbamazepine (Tegretol) 7
Aripiprazole (Abilify) 4
Lurasidone (Latuda) 4

Show all 26 treatments patients report switching to

Last updated:

24 patient evaluations for Depakote

Jan 8, 2009 (Started Dec 31, 2008)

  • Effectiveness
    Moderate (for bipolar rapid cycling)
  • Side effects
    Mild (thirst, nausea)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 500 mg Daily
Advice & Tips: I have only been taking this medicine just over a week and it seems to be working so far. I have experienced some very unpredictable nausea/vomitting. Its not every time I take it and it comes completely out of nowhere. Its weird. One minute I'm fine, then all of a sudden I'm running to the bathroom to get sick, then I'm completely fine again. I haven't really had any upset stomach, which makes this even more bizarre. I'm hoping this will go away with time.
Cost: < $25 monthly
Side effects: thirst, nausea, nausea

Dec 31, 2008 (Started Dec 31, 2008)

  • Effectiveness
    Moderate (for bipolar rapid cycling)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 500 mg Daily
Cost: < $25 monthly
Side effects: thirst, nausea, nausea

  • 1 helpful mark

Nov 1, 2010 (Started Jun 30, 2010)

  • Effectiveness
    Major (for bipolar manic episodes)
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Advice & Tips: Extreme Hair loss/ breakage of hair. Very upsetting. Its a shame because other than losing my hair it worked well.
Cost: < $25 monthly

  • 1 helpful mark

Sep 22, 2008 (Started Jan 01, 2008)

  • Effectiveness
    Moderate (for General health)
  • Side effects
    Mild (fatigue)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 375 mg Daily
Advice & Tips: I take this medication to maintain my awareness. I know what it feels like to be completely depressed, sucidal, etc. I don't ever want to go back to that place.
Cost: < $25 monthly
Side effects: fatigue, nausea

  • 0 helpful marks
Last updated:
Showing 3 of 24 patient evaluations for Depakote