What is Leflunomide?

Category: Prescription Drugs

Most popular types: Arava

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Leflunomide is a disease modifying antirheumatic drug used to treat active rheumatoid arthritis to reduce symptoms, retard structural damage and improve physical function. Also use as to prevent rejection in organ transplants.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 313 116
Systemic lupus erythematosus 33 18
Psoriatic arthritis 15 15
Arthritis pain 4 1
BK virus 4 0

Show all 26 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 35
Moderate 40
Mild 33
None 50

Commonly reported side effects and conditions associated with Leflunomide

Side effect Patients
Diarrhea 17
Nausea 12
Hair loss 10
Elevated liver enzymes 4
Headaches 4
Upset stomach 4

Show all 73 reported side effects

Dosages

Based on patients currently taking Leflunomide

Dosage Patients
20 mg daily 35
10 mg daily 13
45 mg every 12 weeks 1
10 mg twice daily 1
20 mg twice daily 1

Why patients stopped taking Leflunomide

Multiple reasons could be selected

Reason Patients
Side effects too severe 83
Did not seem to work 69
Doctor's advice 59
Other 15
Expense 7
Personal research 5
Course of treatment ended 3
See all 166 patients who've stopped taking Leflunomide

Duration

Currently taking Leflunomide

Duration Patients
Less than 1 month 1
1 - 6 months 6
6 months - 1 year 9
1 - 2 years 7
2 - 5 years 15
5 - 10 years 13
10 years or more 2

Stopped taking Leflunomide

Duration Patients
Less than 1 month 30
1 - 6 months 54
6 months - 1 year 37
1 - 2 years 21
2 - 5 years 17
5 - 10 years 6
10 years or more 2
Adherence
Adherence Evaluations
Always 135
Usually 9
Sometimes 3
Never taken as prescribed 11
Burden
Burden Evaluations
Very hard to take 11
Somewhat hard to take 9
A little hard to take 16
Not at all hard to take 122
Cost per month
Cost per month Evaluations
$200+ 5
$100-199 2
$50-99 7
$25-49 14
< $25 71
Not specified 59

What people switch to and from

Patients started taking Leflunomide after stopping:

Treatment Patients
Methotrexate (Apo-Methotrexate) 43
Hydroxychloroquine (Plaquenil) 18
Sulfasalazine (Salazopyrin) 6
Azathioprine (Imuran) 5
Etanercept (Enbrel SureClick) 3

Show all 13 treatments patients report switching from

Patients stopped taking Leflunomide and switched to:

Treatment Patients
Etanercept (Enbrel SureClick) 7
Methotrexate (Apo-Methotrexate) 7
Adalimumab (Humira) 5
Azathioprine (Imuran) 5
Tofacitinib (Xeljanz) 3

Show all 15 treatments patients report switching to

Last updated:

5 patient evaluations for Leflunomide

Dec 6, 2016 (Started Jan 30, 2014)

  • Effectiveness
    None (for rheumatoid arthritis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Cost: < $25 monthly

May 15, 2014 (Started Jan 30, 2014)

  • Effectiveness
    None (for rheumatoid arthritis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily

  • 0 helpful marks

Mar 16, 2012 (Started Dec 12, 2011)

  • Effectiveness
    None (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Jul 4, 2011 (Started Apr 15, 2011)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 20 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 5 patient evaluations for Leflunomide