What is Hydrocodone-Acetaminophen?

Category: Prescription Drugs

Most popular types: Norco Vicodin Lortab Show all


Hydrocodone is an opiate pain medication used in the relief of moderate to severe pain. Acetaminophen (also known as APAP and paracetamol) is typically used for management of mild to moderate pain; when in combination, it increases the effect of hydrocodone.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Pain 1,880 739
Fibromyalgia 817 339
Pain in lower back 409 196
Back pain 101 67
Muscle pain 77 49

Show all 299 reasons taken

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations

Commonly reported side effects and conditions associated with Hydrocodone-Acetaminophen

Side effect Patients
Constipation 169
Drowsiness 59
Nausea 53
Sleepiness 51
Dizziness 25
Itching 22

Show all 189 reported side effects


Based on patients currently taking Hydrocodone-Acetaminophen

Dosage Patients
325-10 mg four times daily 24
500mg-5mg as needed 21
325-10 mg three times daily 18
325-5mg as needed 17
325mg-10mg as needed 14
325mg-5mg as needed 13
325 mg-10 mg four times daily 10
325-10mg as needed 10
325-5 mg three times daily 9
325-5 mg twice daily 7

See all 142 dosages

Why patients stopped taking Hydrocodone-Acetaminophen

Multiple reasons could be selected

Reason Patients
Other 210
Did not seem to work 206
Doctor's advice 181
Course of treatment ended 141
Side effects too severe 112
Personal research 30
Change in health plan coverage 21
Expense 15
See all 703 patients who've stopped taking Hydrocodone-Acetaminophen


Currently taking Hydrocodone-Acetaminophen

Duration Patients
Less than 1 month 3
1 - 6 months 31
6 months - 1 year 12
1 - 2 years 38
2 - 5 years 108
5 - 10 years 128
10 years or more 71

Stopped taking Hydrocodone-Acetaminophen

Duration Patients
Less than 1 month 118
1 - 6 months 159
6 months - 1 year 99
1 - 2 years 102
2 - 5 years 154
5 - 10 years 67
10 years or more 36
Adherence Evaluations
Always 682
Usually 288
Sometimes 157
Never taken as prescribed 26
Burden Evaluations
Very hard to take 40
Somewhat hard to take 116
A little hard to take 189
Not at all hard to take 808
Cost per month
Cost per month Evaluations
$200+ 2
$100-199 3
$50-99 17
$25-49 75
< $25 661
Not specified 395

What people switch to and from

Patients started taking Hydrocodone-Acetaminophen after stopping:

Treatment Patients
Tramadol (Ultram) 56
Oxycodone-acetaminophen (Percocet) 13
Morphine (Morphine ER) 8
Oxycodone (Oxycodone IR) 8
Codeine-acetaminophen (paracetamol) (Tylenol with Codeine #3) 7

Show all 49 treatments patients report switching from

Patients stopped taking Hydrocodone-Acetaminophen and switched to:

Treatment Patients
Oxycodone-acetaminophen (Percocet) 37
Tramadol (Ultram) 35
Oxycodone (Oxycodone IR) 22
Morphine (Morphine ER) 14
Fentanyl patch (Duragesic-50) 9

Show all 42 treatments patients report switching to

Last updated:

134 patient evaluations for Hydrocodone-Acetaminophen

Sep 17, 2009 (Started Sep 01, 2005)

  • Effectiveness
    Major (for muscle pain)
  • Side effects
  • Adherence
  • Burden
    Not at all hard to take
Dosage: 500 mg-5 mg Daily
Advice & Tips: It grieves me v. much to hear all the negative press and judgementalism about Vicodin users. Of all the treatments I have tried, 1/2 a tab of Vicodin, taken about 4 times a day has been the absolute best treatment, with virtually zero side effects, and allows me to think clearly, and accomplish my studies as a full-time student, as well as work fulltime. Right now, I have had the ability to obtain this drug curtailed by the doubts of my physicians and worries that I am going to abuse it. I suppose this comes from real reports of so many other abusers. However, during the rare times when my pain level is very low, I feel no need to take it and do not take it. So that is my side of the story. If I did not use Vicodin, the most effective agent that allows me the freedom to be the most active in society, I would have spent many more days home from work in bed.
Cost: < $25 monthly

  • 11 helpful marks

Jan 22, 2009 (Started Jan 22, 2004)

  • Effectiveness
    Moderate (for Pain)
  • Effectiveness
    Moderate (for pain in lower back)
  • Side effects
  • Adherence
  • Burden
    Very hard to take
Dosage: As needed
Advice & Tips: If taking this med for a long period of time and even though the med was never abused, it is living hell getting off of it. Please do it slowly and not cold turkey. I only take it now when I have an extremely high level of pain that the Tramadol does not get rid of.
Cost: < $25 monthly

  • 2 helpful marks

May 31, 2009 (Started Apr 19, 2009)

  • Effectiveness
    Moderate (for Pain)
  • Side effects
    Moderate (sleepiness)
  • Adherence
  • Burden
    Not at all hard to take
Dosage: 500 mg-5 mg Daily
Advice & Tips: Trying to get a physician to prescribe pain medications especially opiates, is really difficult. They don't understand that we use it only when we need it and we are not abusing it.
Side effects: sleepiness

  • 1 helpful mark
Last updated:
Showing 3 of 134 patient evaluations for Hydrocodone-Acetaminophen