What is Carbidopa-Levodopa CR?

Category: Prescription Drugs

Most popular types: Sinemet CR Half Sinemet CR Carbilev Show all

false

A controlled release preparation of carbidopa/levodopa formulated to release a lower, smoother dose of medication. It is sometimes taken last thing at night in order to maintain dopamine levels throughout sleep and into the morning.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 297 156
Stiffness/Spasticity 34 15
Improve mobility 14 9
Sleep problems 6 2
Insomnia 5 4
Slowness (bradykinesia) 5 1

Show all 44 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 10
Moderate 27
Mild 35
None 115

Commonly reported side effects and conditions associated with Carbidopa-Levodopa CR

Side effect Patients
Jerky movements (dyskinesia) 12
Vivid dreams 9
Fatigue 8
Nausea 7
Back pain 4
Urine amber color 4

Show all 42 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa CR

Dosage Patients
50 mg-200 mg daily 11
25 mg-100 mg daily 5
50-200 mg daily 3
2 x 25-100 mg daily 2
50-200 mg three times daily 2
3 x 25 mg-100 mg daily 2
2 x 50 mg-200 mg daily 2
4 x 25 mg-100 mg daily 2
4 x 50 mg-200 mg daily 2
3 daily 1

See all 28 dosages

Why patients stopped taking Carbidopa-Levodopa CR

Multiple reasons could be selected

Reason Patients
Doctor's advice 35
Did not seem to work 20
Other 17
Side effects too severe 13
Personal research 5
Course of treatment ended 2
Change in health plan coverage 1
Expense 1
See all 79 patients who've stopped taking Carbidopa-Levodopa CR

Duration

Currently taking Carbidopa-Levodopa CR

Duration Patients
6 months - 1 year 1
1 - 2 years 6
2 - 5 years 14
5 - 10 years 21
10 years or more 10

Stopped taking Carbidopa-Levodopa CR

Duration Patients
Less than 1 month 7
1 - 6 months 21
6 months - 1 year 6
1 - 2 years 18
2 - 5 years 16
5 - 10 years 9
10 years or more 3
Adherence
Adherence Evaluations
Always 134
Usually 38
Sometimes 6
Never taken as prescribed 9
Burden
Burden Evaluations
Very hard to take 7
Somewhat hard to take 17
A little hard to take 57
Not at all hard to take 106
Cost per month
Cost per month Evaluations
$200+ 5
$100-199 4
$50-99 6
$25-49 6
< $25 98
Not specified 68

What people switch to and from

Patients started taking Carbidopa-Levodopa CR after stopping:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 7
Carbidopa-Entacapone-Levodopa (Stalevo) 3
Carbidopa Levodopa ER (Rytary XR) 2
Apomorphine (Apokyn) 1
Entacapone (Comtan) 1

Show all 6 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa CR and switched to:

Treatment Patients
Carbidopa-Levodopa (Sinemet) 8
Carbidopa Levodopa ER (Rytary XR) 4
Apomorphine (Apokyn) 1
Carbidopa-Entacapone-Levodopa (Stalevo) 1
Levodopa-Benserazide (Madopar) 1

Show all 6 treatments patients report switching to

Last updated:

32 patient evaluations for Carbidopa-Levodopa CR

Jun 26, 2017 (Started Jul 17, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: none
Cost: < $25 monthly

  • 0 helpful marks

May 25, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (Breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: I have breakthrough pain at times, but twisting and curling does not happen until 1 to 2 weeks before the next injections. 1 tablet at bedtime.
Cost: < $25 monthly

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: No changes
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (Breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: At times my legs and feet cramp and I use the tens unit during the night.
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (Breakthrough pain)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: No change
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (Breakthrough pain)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: I have breakthrough pain at times, but twisting and curling does not happen until 1 to 2 weeks before the next injections.
Cost: < $25 monthly

Nov 18, 2015 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (Breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: Get up and use Tens unit to help
Cost: < $25 monthly

Sep 16, 2015 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

Jul 15, 2015 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Feb 5, 2017 (Started Jan 10, 2011)

  • Effectiveness
    None (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 4 x 50 mg-200 mg Four times daily
Advice & Tips: Stopped taking Sinemet CR now taking Sinemet 100/25

Dec 28, 2013 (Started Jan 10, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 50 mg-200 mg Daily

Nov 15, 2013 (Started Jan 10, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 3 x 50 mg-200 mg Daily
Advice & Tips: Reintroduced Sinemet CR 6 x half tablets (300 mg total per day)

  • 0 helpful marks
Last updated:
Showing 3 of 32 patient evaluations for Carbidopa-Levodopa CR