What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,671 1,680
Stiffness/Spasticity 111 77
multiple system atrophy 82 55
restless legs syndrome 74 50
Tremor(s) 58 57
Slowness (bradykinesia) 53 35

Show all 98 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 80
Moderate 356
Mild 562
None 799

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 150
Nausea 129
Drowsiness 45
Constipation 28
Headaches 24
Upset stomach 24

Show all 320 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 68
25-100 mg four times daily 33
3 x 25 mg-100 mg daily 28
25 mg-100 mg three times daily 26
25 mg-100 mg four times daily 19
10-100 mg three times daily 17
25-100 mg five times daily 17
2 x 25-100 mg three times daily 17
25 mg-100 mg daily 15
6 x 25 mg-100 mg daily 15

See all 182 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 127
Did not seem to work 103
Side effects too severe 88
Other 70
Personal research 30
Course of treatment ended 18
Change in health plan coverage 7
Expense 5
See all 357 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 2
1 - 6 months 23
6 months - 1 year 50
1 - 2 years 83
2 - 5 years 205
5 - 10 years 225
10 years or more 77

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 39
1 - 6 months 88
6 months - 1 year 57
1 - 2 years 59
2 - 5 years 87
5 - 10 years 39
10 years or more 5
Adherence
Adherence Evaluations
Always 1318
Usually 387
Sometimes 43
Never taken as prescribed 49
Burden
Burden Evaluations
Very hard to take 58
Somewhat hard to take 288
A little hard to take 448
Not at all hard to take 1003
Cost per month
Cost per month Evaluations
$200+ 16
$100-199 21
$50-99 68
$25-49 161
< $25 1003
Not specified 528

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 43
Pramipexole (Mirapex) 31
Amantadine (Symmetrel) 21
Rasagiline (Azilect) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 18

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 48
Carbidopa-Entacapone-Levodopa (Stalevo) 10
Ropinirole (Requip) 9
Carbidopa-Levodopa CR (Sinemet CR) 7
Pramipexole (Mirapex) 7

Show all 17 treatments patients report switching to

Last updated:

131 patient evaluations for Carbidopa-Levodopa

Mar 29, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3.5 x 25 mg-100 mg Daily
Advice & Tips: My Neurologists at the Alfred Hospital in Melbourne Australia tuned my DBS neuro-stimulator so that I no longer take Entacapone and I reduced the amount of Levadopa and Carbidopa That I am taking.I am taking Mirtazone and Sifrol.

  • 0 helpful marks

Mar 24, 2015 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (Toe curling)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 5 x 25 mg-100 mg Daily
Advice & Tips: effectiveness was less than one hour, eating food would reduce effectiveness.
Cost: $25-49 monthly

Sep 27, 2013 (Started Jan 07, 2009)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Moderate (Toe curling)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: Taken at same time as Sinemet CR. Toe curling appears when med starts to work and when it wears off.
Cost: $25-49 monthly

Apr 2, 2013 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: My neuro doubled my Mirapex dosage which allowed me to elimminate "regular" Sinemet. I now take only Sinemet CR every 6 hours along with other meds.
Cost: $25-49 monthly

Jan 9, 2011 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: New Doc prescribes 1.5 tablets 4Xeach day.
Cost: $25-49 monthly

Feb 10, 2009 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Dec 19, 2014 (Started May 15, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly

Oct 17, 2014 (Started May 15, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: Timing is important, I is taking them every 8 hours and that is bad. Now I'm taking them about every six hours during the day and I don't get tired and have cramps in the evening. I still wake up OK. I use a pill box, 7x3 to help remember.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 131 patient evaluations for Carbidopa-Levodopa