What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,702 1,730
Stiffness/Spasticity 111 81
Multiple system atrophy 83 56
Restless legs syndrome 76 62
Tremor(s) 58 57
Slow movement (bradykinesia) 53 36

Show all 91 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 81
Moderate 371
Mild 577
None 820

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 153
Nausea 131
Drowsiness 45
Constipation 30
Headaches 24
Upset stomach 24

Show all 329 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 62
25-100 mg four times daily 25
25 mg-100 mg three times daily 23
3 x 25 mg-100 mg daily 23
25-100 mg five times daily 18
2 x 25-100 mg three times daily 18
4 x 25 mg-100 mg daily 17
25 mg-100 mg four times daily 15
10-100 mg three times daily 14
2 x 25-100 mg four times daily 14

See all 183 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 129
Did not seem to work 106
Side effects too severe 90
Other 69
Personal research 30
Course of treatment ended 18
Change in health plan coverage 7
Expense 5
See all 362 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 1
1 - 6 months 19
6 months - 1 year 39
1 - 2 years 86
2 - 5 years 185
5 - 10 years 217
10 years or more 73

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 40
1 - 6 months 89
6 months - 1 year 59
1 - 2 years 59
2 - 5 years 89
5 - 10 years 38
10 years or more 5
Adherence
Adherence Evaluations
Always 1361
Usually 394
Sometimes 44
Never taken as prescribed 50
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 291
A little hard to take 462
Not at all hard to take 1035
Cost per month
Cost per month Evaluations
$200+ 16
$100-199 22
$50-99 69
$25-49 163
< $25 1042
Not specified 537

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 44
Pramipexole (Mirapex) 33
Amantadine (Symmetrel) 21
Rasagiline (Azilect) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 18

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 50
Carbidopa-Entacapone-Levodopa (Stalevo) 10
Ropinirole (Requip) 10
Carbidopa-Levodopa CR (Sinemet CR) 8
Pramipexole (Mirapex) 7

Show all 18 treatments patients report switching to

Last updated:

131 patient evaluations for Carbidopa-Levodopa

Jun 1, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-250 mg Daily

  • 0 helpful marks

Mar 29, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3.5 x 25 mg-100 mg Daily
Advice & Tips: My Neurologists at the Alfred Hospital in Melbourne Australia tuned my DBS neuro-stimulator so that I no longer take Entacapone and I reduced the amount of Levadopa and Carbidopa That I am taking.I am taking Mirtazone and Sifrol.

  • 0 helpful marks

Mar 24, 2015 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (Toe curling)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 5 x 25 mg-100 mg Daily
Advice & Tips: effectiveness was less than one hour, eating food would reduce effectiveness.
Cost: $25-49 monthly

Sep 27, 2013 (Started Jan 07, 2009)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Moderate (Toe curling)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: Taken at same time as Sinemet CR. Toe curling appears when med starts to work and when it wears off.
Cost: $25-49 monthly

Apr 2, 2013 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: My neuro doubled my Mirapex dosage which allowed me to elimminate "regular" Sinemet. I now take only Sinemet CR every 6 hours along with other meds.
Cost: $25-49 monthly

Jan 9, 2011 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: New Doc prescribes 1.5 tablets 4Xeach day.
Cost: $25-49 monthly

Feb 10, 2009 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 131 patient evaluations for Carbidopa-Levodopa