What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,782 1,802
Stiffness/spasticity 111 83
Multiple system atrophy 84 56
Restless legs syndrome 79 67
Tremor(s) 60 57
Slow movement (bradykinesia) 53 36

Show all 91 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
84
Moderate
386
Mild
597
None
854

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements 159
Nausea 137
Drowsiness 47
Constipation 32
Headaches 24
Upset stomach 24

Show all 342 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 75
25-100 mg four times daily 32
3 x 25 mg-100 mg daily 32
25 mg-100 mg three times daily 29
25-100 mg five times daily 21
2 x 25-100 mg three times daily 21
4 x 25 mg-100 mg daily 20
25 mg-100 mg daily 19
2 x 25-100 mg four times daily 18
25-100 mg twice daily 14

See all 193 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 133
Did not seem to work 108
Side effects too severe 94
Other 75
Personal research 30
Course of treatment ended 18
Change in health plan coverage 7
Expense 5
See all 375 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 1
1 - 6 months 16
6 months - 1 year 48
1 - 2 years 83
2 - 5 years 208
5 - 10 years 269
10 years or more 83

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 48
1 - 6 months 86
6 months - 1 year 58
1 - 2 years 60
2 - 5 years 93
5 - 10 years 41
10 years or more 6
Adherence
Adherence Evaluations
Always 1408
Usually 410
Sometimes 46
Never taken as prescribed 57
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 303
A little hard to take 479
Not at all hard to take 1078
Cost per month
Cost per month Evaluations
$200+ 17
$100-199 22
$50-99 71
$25-49 171
< $25 1073
Not specified 567

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 48
Pramipexole (Mirapex) 40
Rasagiline (Azilect) 23
Amantadine (Symmetrel) 20
Carbidopa-Entacapone-Levodopa (Stalevo) 18

Show all 17 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 57
Carbidopa-Entacapone-Levodopa (Stalevo) 14
Ropinirole (Requip) 10
Carbidopa-Levodopa CR (Sinemet CR) 9
Pramipexole (Mirapex) 8

Show all 20 treatments patients report switching to

Last updated:

132 patient evaluations for Carbidopa-Levodopa

Jun 1, 2015 (Started Aug 18, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 18, 2011 (Started Aug 18, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily

  • 1 helpful mark

Jun 1, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-250 mg Daily

  • 0 helpful marks

Mar 29, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3.5 x 25 mg-100 mg Daily
Advice & Tips: My Neurologists at the Alfred Hospital in Melbourne Australia tuned my DBS neuro-stimulator so that I no longer take Entacapone and I reduced the amount of Levadopa and Carbidopa That I am taking.I am taking Mirtazone and Sifrol.

  • 0 helpful marks
Last updated:
Showing 3 of 132 patient evaluations for Carbidopa-Levodopa