What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,745 1,765
Stiffness/spasticity 111 82
Multiple system atrophy 83 56
Restless legs syndrome 79 65
Tremor(s) 60 57
Slow movement (bradykinesia) 53 36

Show all 92 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 83
Moderate 380
Mild 583
None 838

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 154
Nausea 133
Drowsiness 47
Constipation 31
Headaches 24
Upset stomach 24

Show all 335 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 65
3 x 25 mg-100 mg daily 32
25-100 mg four times daily 27
25 mg-100 mg three times daily 26
2 x 25-100 mg three times daily 18
4 x 25 mg-100 mg daily 18
25-100 mg five times daily 17
25-100 mg twice daily 14
2 x 25-100 mg four times daily 14
25-250 mg four times daily 11

See all 182 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 130
Did not seem to work 106
Side effects too severe 91
Other 72
Personal research 30
Course of treatment ended 18
Change in health plan coverage 8
Expense 5
See all 367 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 3
1 - 6 months 20
6 months - 1 year 42
1 - 2 years 81
2 - 5 years 188
5 - 10 years 229
10 years or more 76

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 41
1 - 6 months 89
6 months - 1 year 60
1 - 2 years 59
2 - 5 years 90
5 - 10 years 40
10 years or more 5
Adherence
Adherence Evaluations
Always 1387
Usually 399
Sometimes 46
Never taken as prescribed 52
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 299
A little hard to take 470
Not at all hard to take 1054
Cost per month
Cost per month Evaluations
$200+ 17
$100-199 22
$50-99 70
$25-49 166
< $25 1057
Not specified 552

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 46
Pramipexole (Mirapex) 33
Rasagiline (Azilect) 22
Amantadine (Symmetrel) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 18

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 50
Carbidopa-Entacapone-Levodopa (Stalevo) 12
Ropinirole (Requip) 10
Carbidopa-Levodopa CR (Sinemet CR) 8
Pramipexole (Mirapex) 7

Show all 19 treatments patients report switching to

Last updated:

132 patient evaluations for Carbidopa-Levodopa

Jun 1, 2015 (Started Aug 18, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 18, 2011 (Started Aug 18, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily

  • 1 helpful mark

Jun 1, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-250 mg Daily

  • 0 helpful marks

Mar 29, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3.5 x 25 mg-100 mg Daily
Advice & Tips: My Neurologists at the Alfred Hospital in Melbourne Australia tuned my DBS neuro-stimulator so that I no longer take Entacapone and I reduced the amount of Levadopa and Carbidopa That I am taking.I am taking Mirtazone and Sifrol.

  • 0 helpful marks
Last updated:
Showing 3 of 132 patient evaluations for Carbidopa-Levodopa