What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,834 1,862
Stiffness/spasticity 111 83
Multiple system atrophy 86 58
Restless legs syndrome 79 68
Tremor(s) 60 57
Slow movement (bradykinesia) 53 36

Show all 91 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 87
Moderate 393
Mild 610
None 891

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements 162
Nausea 139
Drowsiness 48
Constipation 32
Upset stomach 26
Headaches 25

Show all 344 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 82
25-100 mg four times daily 44
25 mg-100 mg three times daily 33
3 x 25 mg-100 mg daily 32
25-100 mg five times daily 25
4 x 25 mg-100 mg daily 22
2 x 25-100 mg three times daily 20
25 mg-100 mg daily 19
6 x 25 mg-100 mg daily 18
25-100 mg twice daily 17

See all 207 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 136
Did not seem to work 112
Side effects too severe 97
Other 75
Personal research 31
Course of treatment ended 20
Change in health plan coverage 7
Expense 5
See all 380 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
1 - 6 months 26
6 months - 1 year 45
1 - 2 years 94
2 - 5 years 238
5 - 10 years 277
10 years or more 105

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 48
1 - 6 months 89
6 months - 1 year 55
1 - 2 years 62
2 - 5 years 94
5 - 10 years 41
10 years or more 9
Adherence
Adherence Evaluations
Always 1452
Usually 421
Sometimes 48
Never taken as prescribed 60
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 311
A little hard to take 492
Not at all hard to take 1117
Cost per month
Cost per month Evaluations
$200+ 18
$100-199 23
$50-99 68
$25-49 171
< $25 1110
Not specified 591

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 47
Pramipexole (Mirapex) 43
Rasagiline (Azilect) 24
Amantadine (Symmetrel) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 19

Show all 18 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 62
Carbidopa-Entacapone-Levodopa (Stalevo) 14
Ropinirole (Requip) 13
Carbidopa-Levodopa CR (Sinemet CR) 10
Pramipexole (Mirapex) 10

Show all 21 treatments patients report switching to

Last updated:

133 patient evaluations for Carbidopa-Levodopa

Jun 20, 2015 (Started May 18, 2014)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (muscle rigidity)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: In the last six months, I have gotten much weaker and have very little energy. I always try to lay down for one hour in the afternoon. My balance is not as good as in the past.
Cost: < $25 monthly

Jun 23, 2010 (Started May 18, 2014)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I saw a huge increase in my energy level. I became more active and I noticed that I did not lay down and rest as often. I don't believe that I have any side effects. It is a little difficult since you need to take it before you eat, like 1/2 hour. It is very helpful.
Cost: < $25 monthly

  • 0 helpful marks

Jun 1, 2015 (Started Aug 18, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 18, 2011 (Started Aug 18, 2009)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily

  • 1 helpful mark

Jun 1, 2015 (Started Jun 30, 2012)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-250 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 133 patient evaluations for Carbidopa-Levodopa