What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's Disease 2,475 1,482
Stiffness/Spasticity 111 73
MSA (Multiple System Atrophy) 79 53
RLS (Restless Legs Syndrome) 68 45
Tremor(s) 58 56
Slowness 48 32

Show all 98 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 72
Moderate 317
Mild 500
None 701

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 144
Nausea 119
Drowsiness 43
Constipation 26
Upset stomach 24
Headaches 22

Show all 299 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 51
25 mg-100 mg three times daily 40
3 x 25 mg-100 mg daily 33
25-100 mg four times daily 28
2 x 25-100 mg three times daily 20
4 x 25 mg-100 mg daily 20
2 x 25-100 mg four times daily 16
25 mg-100 mg four times daily 16
25-100 mg five times daily 15
2 x 25 mg-100 mg daily 15

See all 171 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 124
Did not seem to work 95
Side effects too severe 79
Other 70
Personal research 28
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 341 patients who’ve stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 1
1 - 6 months 28
6 months - 1 year 48
1 - 2 years 89
2 - 5 years 193
5 - 10 years 196
10 years or more 67

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 37
1 - 6 months 82
6 months - 1 year 55
1 - 2 years 59
2 - 5 years 82
5 - 10 years 38
10 years or more 5
Adherence
Adherence Evaluations
Always 1162
Usually 348
Sometimes 39
Never taken as prescribed 41
Burden
Burden Evaluations
Very hard to take 55
Somewhat hard to take 266
A little hard to take 398
Not at all hard to take 871
Cost per month
Cost per month Evaluations
$200+ 12
$100-199 21
$50-99 62
$25-49 141
< $25 883
Not specified 471

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 33
Pramipexole (Mirapex) 25
Carbidopa-Entacapone-Levodopa (Stalevo) 17
Rasagiline (Azilect) 15
Amantadine (Symmetrel) 12

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 40
Carbidopa-Entacapone-Levodopa (Stalevo) 9
Carbidopa-Levodopa CR (Sinemet CR) 6
Ropinirole (Requip) 6
Carbidopa-Levodopa (Sinemet) 5

Show all 17 treatments patients report switching to

Last updated:

128 patient evaluations for Carbidopa-Levodopa

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palecarl
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palecarl
Sex: F
Data Quality: 2 stars
On
Mouth/throat: none
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See palecarl's full Carbidopa-Levodopa history

Jun 19, 2014 (Started May 15, 2012)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily

  • 0 helpful marks
StrkL
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StrkL
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: none
Chest: none
Legs: mild
I am: g
I have:
Parkinson's

See StrkL's full Carbidopa-Levodopa history

May 11, 2014 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: As of today, I am still taking six sinemet daily, two pills at a time. Even when I am off, I can write and type almost as well as ever. And even when off, I have no tremor (unless I try to walk, then my right hand shakes.) And when I am on, my walking is generally normal. (I sometimes have problems with freezing when on.) My balance is also much better when I'm on. When off, I have difficulty standing on one leg, but I can do so for a minute or more when on.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

Sep 19, 2010 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: At my most recent neurologist visit, she told me I had dyskinesias. My wife has also noticed them. I'm not sure how long I"ve had them, probably a few months. At my previous visit, three months ago (when I saw the Nurse Practitioner, not the neurologist), the Nurse did not mention them. They are quite mild - at least mild enough that I don't notice. My neurologist has suggested I take more Amantadine to see if this reduces them.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

Mar 29, 2009 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: The first neurologist I saw, in March 2006, had me try a couple of sinemet per day. They had absolutely no effect. The second neurologist I saw, in April 2007, had me take a half tablet per day for the first week, one tablet daily the second, one and a half daily the third, and so on until I was taking four daily after eight weeks. It had no effect until the fifth week, when I started taking two and a half tablets daily. At that time, it improved my eating, dressing, and showering, but did not improve my writing or typing or walking. Later in 2007 I went to five sinemet daily, with little change. During the summer of 2008 I went to six, and my writing and typing essentially became normal. Even when off I’m able to write and type almost as well as ever. And I have no tremor. My walking improved dramatically as well – I could walk a mile or more first thing in the morning after taking my medication. But I would be off a substantial part of the day. I was taking one pill at 5 AM, 9 AM, noon, 3 PM, 6 PM, and 9 PM. In the fall of 2008 I went to taking two pills at 5 AM, 8 AM, and 1 PM. This improved my walking considerably.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

  • 0 helpful marks
princess adventurous
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princess adventurous
Sex: F
Data Quality: 0 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See princess adventurous's full Carbidopa-Levodopa history

Feb 14, 2014 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 128 patient evaluations for Carbidopa-Levodopa