What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's Disease 2,647 1,637
Stiffness/Spasticity 111 77
MSA (Multiple System Atrophy) 82 55
RLS (Restless Legs Syndrome) 74 50
Tremor(s) 58 57
Slowness (bradykinesia) 53 35

Show all 97 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 78
Moderate 350
Mild 548
None 781

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 149
Nausea 128
Drowsiness 45
Constipation 28
Headaches 24
Upset stomach 24

Show all 314 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 70
3 x 25 mg-100 mg daily 32
25-100 mg four times daily 31
25 mg-100 mg three times daily 26
10-100 mg three times daily 21
25 mg-100 mg four times daily 19
25-100 mg five times daily 18
2 x 25-100 mg three times daily 17
6 x 25 mg-100 mg daily 14
4 x 25 mg-100 mg daily 13

See all 179 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 127
Did not seem to work 102
Side effects too severe 85
Other 71
Personal research 30
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 354 patients who’ve stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 4
1 - 6 months 33
6 months - 1 year 62
1 - 2 years 101
2 - 5 years 209
5 - 10 years 196
10 years or more 71

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 38
1 - 6 months 87
6 months - 1 year 56
1 - 2 years 59
2 - 5 years 86
5 - 10 years 40
10 years or more 5
Adherence
Adherence Evaluations
Always 1285
Usually 381
Sometimes 42
Never taken as prescribed 49
Burden
Burden Evaluations
Very hard to take 58
Somewhat hard to take 285
A little hard to take 436
Not at all hard to take 978
Cost per month
Cost per month Evaluations
$200+ 16
$100-199 21
$50-99 68
$25-49 159
< $25 976
Not specified 517

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 42
Pramipexole (Mirapex) 29
Rasagiline (Azilect) 20
Amantadine (Symmetrel) 19
Carbidopa-Entacapone-Levodopa (Stalevo) 18

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 47
Carbidopa-Entacapone-Levodopa (Stalevo) 10
Ropinirole (Requip) 9
Carbidopa-Levodopa CR (Sinemet CR) 7
Pramipexole (Mirapex) 7

Show all 17 treatments patients report switching to

Last updated:

130 patient evaluations for Carbidopa-Levodopa

1,101 members have decided to share their profiles only with other members of PatientsLikeMe.

stickyfingers
1747 thumb
stickyfingers
Sex: M
Data Quality: 3 stars
On
Mouth/throat: none
Arms: none
Chest: none
Legs: none
I am: vg
I have:
Parkinson's

See stickyfingers's full Carbidopa-Levodopa history

Mar 24, 2015 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Moderate (Toe curling)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 5 x 25 mg-100 mg Daily
Advice & Tips: effectiveness was less than one hour, eating food would reduce effectiveness.
Cost: $25-49 monthly

Sep 27, 2013 (Started Jan 07, 2009)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Toe curling)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: Taken at same time as Sinemet CR. Toe curling appears when med starts to work and when it wears off.
Cost: $25-49 monthly

Apr 2, 2013 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: My neuro doubled my Mirapex dosage which allowed me to elimminate "regular" Sinemet. I now take only Sinemet CR every 6 hours along with other meds.
Cost: $25-49 monthly

Jan 9, 2011 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: New Doc prescribes 1.5 tablets 4Xeach day.
Cost: $25-49 monthly

Feb 10, 2009 (Started Jan 07, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
archaeologist
Portrait default thumb
archaeologist
Sex: M
Data Quality: 2 stars
On
Mouth/throat: none
Arms: none
Chest: none
Legs: mild
I am: b
I have:
Parkinson's

See archaeologist's full Carbidopa-Levodopa history

Dec 19, 2014 (Started May 15, 2013)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly

Oct 17, 2014 (Started May 15, 2013)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: Timing is important, I is taking them every 8 hours and that is bad. Now I'm taking them about every six hours during the day and I don't get tired and have cramps in the evening. I still wake up OK. I use a pill box, 7x3 to help remember.
Cost: $25-49 monthly

  • 0 helpful marks
palecarl
46332 thumb
palecarl
Sex: F
Data Quality: 2 stars
On
Mouth/throat: none
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See palecarl's full Carbidopa-Levodopa history

Jun 19, 2014 (Started May 15, 2012)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 130 patient evaluations for Carbidopa-Levodopa