What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 2,235 1,265
Depressed mood 1,595 783
Persistent depressive disorder (dysthymia) 389 317
Mild depression 152 65
Anxious mood 121 64

Show all 193 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
264
Moderate
375
Mild
605
None
1,105

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 104
Anxious mood 70
Weight gain 55
Insomnia 50
Headaches 47
Constipation 43

Show all 441 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 184
150 mg daily 140
100 mg daily 77
300 mg/24 hours daily 64
450 mg daily 55
75 mg daily 43
150 mg twice daily 37
100 mg twice daily 31
200 mg daily 30
150 mg/24 hours daily 23

See all 75 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 646
Side effects too severe 542
Doctor's advice 418
Other 272
Course of treatment ended 88
Expense 82
Personal research 70
Change in health plan coverage 42
See all 1569 patients who've stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 4
1 - 6 months 82
6 months - 1 year 75
1 - 2 years 110
2 - 5 years 203
5 - 10 years 187
10 years or more 170

Stopped taking Bupropion

Duration Patients
Less than 1 month 332
1 - 6 months 354
6 months - 1 year 245
1 - 2 years 226
2 - 5 years 272
5 - 10 years 120
10 years or more 58
Adherence
Adherence Evaluations
Always 1835
Usually 352
Sometimes 54
Never taken as prescribed 108
Burden
Burden Evaluations
Very hard to take 78
Somewhat hard to take 147
A little hard to take 338
Not at all hard to take 1786
Cost per month
Cost per month Evaluations
$200+ 13
$100-199 24
$50-99 85
$25-49 174
< $25 1133
Not specified 920

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 92
Fluoxetine (Prozac) 84
Venlafaxine (Effexor XR) 70
Citalopram (Celexa) 50
Duloxetine (Cymbalta) 49

Show all 55 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 46
Sertraline (Zoloft) 45
Venlafaxine (Effexor XR) 35
Citalopram (Celexa) 31
Fluoxetine (Prozac) 28

Show all 46 treatments patients report switching to

Last updated:

184 patient evaluations for Bupropion

Dec 19, 2011 (Started Jan 23, 2008)

  • Effectiveness
    Can’t tell (for fatigue)
  • Effectiveness
    Can’t tell (for problems concentrating)
  • Effectiveness
    Moderate (for persistent depressive disorder (dysthymia))
  • Side effects
    Moderate (irritability, hypersexuality, alcohol consumption, feeling well, energetic, craving alcohol, sleeplessness, insomnia, bruxism (teeth grinding), agitation with irritability)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 13 mg Daily
Advice & Tips: Titrated downward twice in two weeks for the usual adverse effects: hypersexuality, insomnia, craving alcohol, slight hyperacusis (ear pulse), mild teeth grinding.
Cost: < $25 monthly
Side effects: irritability, sleeplessness, feeling well, energetic, alcohol consumption, craving alcohol, hypersexuality

Sep 30, 2010 (Started Jan 23, 2008)

  • Effectiveness
    Can’t tell (for depressed mood)
  • Effectiveness
    Can’t tell (for fatigue)
  • Effectiveness
    Can’t tell (for problems concentrating)
  • Side effects
    Moderate (irritability, hypersexuality, alcohol consumption, feeling well, energetic, craving alcohol, sleeplessness, insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Advice & Tips: At prescribed doses, induced hypomania. At lower doses, may have helped with concentration, depression and fatigue—or not. Did keep me awake if I took it after noon. Stopped because I came to see it as contributing to irritability. This gets complicated, because giving it up can do the same—perhaps because it's habituating/addictive. Be all that as it may, I feel better off without it now.
Cost: < $25 monthly
Side effects: irritability, sleeplessness, feeling well, energetic, alcohol consumption, craving alcohol, hypersexuality

Aug 5, 2009 (Started Jan 23, 2008)

  • Effectiveness
    Moderate (for fatigue)
  • Effectiveness
    Can’t tell (for problems concentrating)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Moderate (hypersexuality, alcohol consumption, feeling well, energetic, craving alcohol, sleeplessness, insomnia)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 68 mg Daily
Advice & Tips: Dosage, dosage, dosage! Be observant about effects, report them, and work with your prescriber to optimize the dose. Micromanage as needed. Use the instant mood readings to spot trends. Get multiiple prescriptions (in different dosages) if that's what you need to manage and your prescriber will cooperate.
Cost: < $25 monthly
Side effects: irritability, sleeplessness, feeling well, energetic, alcohol consumption, craving alcohol, hypersexuality

Feb 21, 2009 (Started Jan 23, 2008)

  • Effectiveness
    Moderate (for problems concentrating)
  • Side effects
    Mild (feeling well, energetic, craving alcohol, sleeplessness, insomnia)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 68 mg Daily
Advice & Tips: Be vigilant about effects, particularly hypomania, and how they relate to dosage and timing of dose. Charting your instant mood can be very helpful for this. It works for me to adjust the dose according to my pattern of good and bad days, and this helps a lot in evening out my moods. If you notice tinnitus, particularly pounding in the ears at night, check out other causes; bupropion may be making you more sensitive to something that you can fix with an earwash or other measures.
Cost: < $25 monthly
Side effects: irritability, sleeplessness, feeling well, energetic, alcohol consumption, craving alcohol, hypersexuality

Nov 10, 2008 (Started Jan 23, 2008)

  • Effectiveness
    Major (for problems concentrating)
  • Side effects
    Moderate (feeling well, energetic, craving alcohol, sleeplessness, insomnia)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 60 mg Daily
Advice & Tips: Dosage, dosage, dosage! Observe the effects, and work with your prescriber to find the dose that's best for you (assuming this is the right drug for you, which of course may not be the case). Through quite a bit of trial and error, I arrived at a dose of about 60 mg a day, which I manage by taking 50 mg (half a 100 mg tablet) 4 days a week and 75 mg (the smallest tab available) 3 days a week. I'm generally sensitive to medications, and many people tolerate and benefit from much more, but the same principle applies: weigh the cost and benefits and see if you can optimize their balance through adjusting dosage (always in consultation with your prescriber).
Cost: < $25 monthly
Side effects: irritability, sleeplessness, feeling well, energetic, alcohol consumption, craving alcohol, hypersexuality

Aug 19, 2008 (Started Jan 23, 2008)

  • Effectiveness
    Moderate (for problems concentrating)
  • Side effects
    Moderate (feeling well, energetic, craving alcohol, sleeplessness, insomnia)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 60 mg Daily
Advice & Tips: This is in my experience and according to a friend's report a "speedy" drug. Watch effects carefully and be prepared to adjust dosage as needed.
Cost: < $25 monthly
Side effects: irritability, sleeplessness, feeling well, energetic, alcohol consumption, craving alcohol, hypersexuality

  • 6 helpful marks

Jul 15, 2012 (Started Mar 09, 2009)

  • Effectiveness
    Can’t tell (for Treat my mood condition(s))
  • Effectiveness
    Can’t tell (for Other)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 450 mg Daily
Advice & Tips: helped with decreasing appetite. helped with increased sex drive. probably "fueling" mania
Cost: < $25 monthly

Aug 5, 2009 (Started Mar 09, 2009)

  • Effectiveness
    Major (for Other)
  • Effectiveness
    Major (for Treat my mood condition(s))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 450 mg Daily
Advice & Tips: for the most part i have little to no appetite when i'm on this drug and was able to loose over 40 pounds after going on it. i've since also gone on lamictal and lithium and have gained about 20 pounds. my daughters say i look much healthier now. i also like this drug because i don't feel it affects me sexually--i.e. it does not affect my sex drive when i am on it. i just have a $10 copay monthly. insurance pays the following.
Cost: $100-199 monthly

  • 5 helpful marks

Oct 13, 2010 (Started Sep 08, 2010)

  • Effectiveness
    None (for bipolar disorder)
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 150 mg/24 hours Daily
Advice & Tips: Very depressed, very tired, totally out of focus. No use taking an AD when it makes you more depressed, especially after 8 weeks. Went off of it cold turkey and never looked back.
Cost: < $25 monthly

Oct 1, 2010 (Started Sep 08, 2010)

  • Effectiveness
    Moderate (for bipolar disorder)
  • Side effects
    Mild
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg/24 hours Daily
Advice & Tips: This version of Wellbutrin drops out half way through the day and I get severe depression for about an hour then I go back to a low level depression. Helping remotely. Switched to Wellbutrin SR to level the med out throughout the day.
Cost: < $25 monthly

  • 2 helpful marks
Last updated:
Showing 3 of 184 patient evaluations for Bupropion