What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 2,345 1,330
Depressed mood 1,634 814
Persistent depressive disorder (dysthymia) 409 338
Mild depression 157 70
Anxious mood 121 64

Show all 181 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 283
Moderate 386
Mild 632
None 1,162

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 110
Anxious mood 72
Weight gain 59
Insomnia 54
Headaches 48
Constipation 43

Show all 359 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 163
150 mg daily 105
100 mg daily 64
300 mg/24 hours daily 54
450 mg daily 48
75 mg daily 38
150 mg twice daily 34
100 mg twice daily 25
150 mg/24 hours daily 21
200 mg daily 17

See all 58 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 672
Side effects too severe 568
Doctor's advice 444
Other 286
Course of treatment ended 96
Expense 84
Personal research 73
Change in health plan coverage 45
See all 1650 patients who've stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 1
1 - 6 months 27
6 months - 1 year 35
1 - 2 years 101
2 - 5 years 194
5 - 10 years 175
10 years or more 147

Stopped taking Bupropion

Duration Patients
Less than 1 month 363
1 - 6 months 367
6 months - 1 year 239
1 - 2 years 234
2 - 5 years 290
5 - 10 years 129
10 years or more 67
Adherence
Adherence Evaluations
Always 1933
Usually 361
Sometimes 52
Never taken as prescribed 117
Burden
Burden Evaluations
Very hard to take 84
Somewhat hard to take 148
A little hard to take 345
Not at all hard to take 1886
Cost per month
Cost per month Evaluations
$200+ 16
$100-199 27
$50-99 86
$25-49 180
< $25 1171
Not specified 983

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 96
Fluoxetine (Prozac) 94
Venlafaxine (Effexor XR) 75
Citalopram (Celexa) 55
Duloxetine (Cymbalta) 49

Show all 55 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 52
Sertraline (Zoloft) 49
Venlafaxine (Effexor XR) 36
Citalopram (Celexa) 33
Escitalopram (Lexapro) 32

Show all 48 treatments patients report switching to

Last updated:

188 patient evaluations for Bupropion

Jul 1, 2007 (Started Jul 01, 2006)

  • Effectiveness
    Can't tell (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily

  • 0 helpful marks

Mar 1, 2007 (Started Aug 19, 2006)

  • Effectiveness
    Moderate (for persistent depressive disorder (dysthymia))
  • Side effects
    Mild (weight loss)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: $25-49 monthly
Side effects: weight loss

  • 0 helpful marks

Dec 15, 2006 (Started Dec 15, 2005)

  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    Moderate (excessive sweating, agitation, elevated blood pressure, constipation)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 75 mg Daily
Advice & Tips: If you are the type of person where you are a bit nervous naturally, on edge, then this anti-depressant is not the right choice for you. It is very popular as it works with dopamine, but for me it didn't help me as much as it made me constantly nervous, and I would go through extreme sweating from time to time especially a couple hours after I would take it. As I reflect back, I would get a lot of anxiousness, and had a hard time being in groups, which was never a problem prior.
Cost: $25-49 monthly
Side effects: constipation, elevated blood pressure, agitation, excessive sweating, elevated blood pressure, agitation, excessive sweating

  • 1 helpful mark
Last updated:
Showing 3 of 188 patient evaluations for Bupropion