What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Wellbutrin SR Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major Depressive Disorder 1,597 894
Depressed mood 1,475 693
Persistent depressive disorder (dysthymia) 312 265
Mild Depression 132 51
Anxious mood 113 52
Bipolar Disorder 97 81

Show all 203 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 213
Moderate 296
Mild 492
None 843

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 84
Anxious mood 52
Insomnia 44
Weight gain 41
Constipation 38
Headaches 38

Show all 385 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
150 mg daily 83
300 mg daily 77
300 mg/24 hours daily 69
100 mg daily 49
150 mg/24 hours daily 32
450 mg daily 29
75 mg daily 28
100 mg twice daily 28
200 mg daily 22
150 mg twice daily 17

See all 57 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 513
Side effects too severe 441
Doctor's advice 354
Other 241
Expense 76
Course of treatment ended 75
Personal research 62
Change in health plan coverage 34
See all 1296 patients who’ve stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 3
1 - 6 months 25
6 months - 1 year 51
1 - 2 years 92
2 - 5 years 141
5 - 10 years 144
10 years or more 86

Stopped taking Bupropion

Duration Patients
Less than 1 month 249
1 - 6 months 316
6 months - 1 year 198
1 - 2 years 191
2 - 5 years 232
5 - 10 years 105
10 years or more 44
Adherence
Adherence Evaluations
Always 1444
Usually 297
Sometimes 41
Never taken as prescribed 62
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 111
A little hard to take 283
Not at all hard to take 1389
Cost per month
Cost per month Evaluations
$200+ 10
$100-199 22
$50-99 73
$25-49 149
< $25 899
Not specified 691

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 50
Fluoxetine (Prozac) 39
Venlafaxine (Effexor XR) 36
Duloxetine (Cymbalta) 30
Citalopram (Celexa) 23

Show all 36 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 31
Sertraline (Zoloft) 23
Venlafaxine (Effexor XR) 17
Citalopram (Celexa) 15
Bupropion (Wellbutrin XL) 13

Show all 34 treatments patients report switching to

Last updated:

183 patient evaluations for Bupropion

1,383 members have decided to share their profiles only with other members of PatientsLikeMe.

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zoomer
Gender: F
Data Quality: 3 stars
Depression: 1
Mania: 0
Emotional: 1
Anxiety: 1
Compulsion: 0
External Stress: Low
61 F
Function: High
Distress: Low
I am: g
I have:
Bipolar I

See zoomer's full Bupropion history

Nov 29, 2015 (Started Dec 04, 2009)

  • Effectiveness
    None (for Tobacco Addiction)
  • Effectiveness
    Moderate (for Major Depressive Disorder)
  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Moderate (for Bipolar Disorder)
  • Effectiveness
    Moderate (for Anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: Just wanting to update. I continue taking Wellbutrin daily in the morning. I have many helpful strategies for reducing anxiety. Pair those coping skills with this medication, I have been able to avoid the benzodiazepines.
Cost: < $25 monthly

Apr 6, 2011 (Started Dec 04, 2009)

  • Effectiveness
    Can’t tell (for Bipolar Disorder)
  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Moderate (for Anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I initially asked Pdoc for this med to assist my stop smoking nicotine efforts. The effects of the anti-anxiety component were noticeable behaviorally: symptoms reduced and intensity of symptoms lessened. As far as helping with my depression, I have been without an episode of major depression for as long as I have been taking wellbutrin. I don't allocate all credit to this med. I take Pristiq also. So, did it help me quit smoking? not yet.
Cost: < $25 monthly

Oct 25, 2010 (Started Dec 04, 2009)

  • Effectiveness
    Can’t tell (for Bipolar Disorder)
  • Effectiveness
    Slight (for Depressed mood)
  • Effectiveness
    Moderate (for Anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I have noticed a more consistent level of lower anxiety on Wellbutrin. It has also noticeably helped decrease the depression a degree during episodes. I have also decreased my tabacco intake since taking .
Cost: < $25 monthly

  • 1 helpful mark
John Jamson
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John Jamson
Gender: M
Data Quality: 1 star
Depression: 1
Mania: 0
Emotional: 0
Anxiety: 1
Compulsion: 1
External Stress: Severe
36 M
Function: High
Distress: Low
I am: n
I have:
Major Depressive Disorder

See John Jamson's full Bupropion history

Nov 13, 2015 (Started Sep 18, 2009)

  • Effectiveness
    Moderate (for Persistent depressive disorder (dysthymia))
  • Effectiveness
    Moderate (for Major Depressive Disorder)
  • Effectiveness
    None (for Fatigue)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Cost: $25-49 monthly

Oct 4, 2014 (Started Sep 18, 2009)

  • Effectiveness
    Moderate (for Fatigue)
  • Effectiveness
    Moderate (for Depressed mood)
  • Effectiveness
    Moderate (for Persistent depressive disorder (dysthymia))
  • Effectiveness
    Moderate (for Major Depressive Disorder)
  • Side effects
    Mild (Weight gain)
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 200 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Keeper of the Flame
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Keeper of the Flame
Gender: F
Data Quality: 3 stars
Pain: All
Fatigue: Most
Sleep: All
Stiffness: All
function: None
external_stress: Most
Stickman: all
Description:F59y
CFS:?y
FM:8y Dx
I am: b
I have:
Fibromyalgia

See Keeper of the Flame's full Bupropion history

Oct 1, 2015 (Started Apr 27, 2012)

  • Effectiveness
    Slight (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: I took the Bupropion until about January of 2015 and then I decided I had had just about enough of a bunch of meds that didn't work so I stopped taking them. Things went south in May 2015 when my Mother-In-Law died unexpectedly and so in April I started back on the Bupropion but my doctor also has me taking Provigil for my fatigue and I am doing a lot better now. I still don't know if the Bupropion is helping me or not. I am still tired a lost. Fatigued body and mind. (Sigh) Even with taking 200mg of Provigil a day. I guess I need more sleep but I don't think that will help any. Even when I get hours and hours of sleep the fatigue is still there. I take the bupropion in the mornings.
Cost: < $25 monthly

May 26, 2013 (Started Apr 27, 2012)

  • Effectiveness
    Can’t tell (for Fatigue)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Advice & Tips: I am very tired all of the time so my psychiatrist has prescribed this medication to see if it gives me any pep. I have been taking it for months now with no change in my exhaustion. As of Feb. 2013 I have been taking 300mg in the morning and 200mg in the afternoon. I forget to take the 200mg in the afternoon a lot of the time.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 183 patient evaluations for Bupropion