What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Wellbutrin SR Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major Depressive Disorder 1,538 849
Depressed mood 1,469 684
Persistent depressive disorder (dysthymia) 299 249
Mild Depression 131 51
Anxious mood 113 51
Bipolar Disorder 95 80

Show all 202 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 208
Moderate 284
Mild 473
None 817

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 83
Anxious mood 50
Insomnia 44
Headaches 37
Constipation 36
Weight gain 36

Show all 371 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
150 mg daily 83
300 mg/24 hours daily 72
300 mg daily 67
100 mg daily 41
150 mg/24 hours daily 34
75 mg daily 25
450 mg daily 24
100 mg twice daily 20
150 mg twice daily 17
200 mg daily 16

See all 55 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 503
Side effects too severe 427
Doctor's advice 344
Other 239
Course of treatment ended 75
Expense 75
Personal research 62
Change in health plan coverage 34
See all 1273 patients who’ve stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 3
1 - 6 months 32
6 months - 1 year 44
1 - 2 years 78
2 - 5 years 129
5 - 10 years 130
10 years or more 75

Stopped taking Bupropion

Duration Patients
Less than 1 month 242
1 - 6 months 312
6 months - 1 year 197
1 - 2 years 184
2 - 5 years 229
5 - 10 years 104
10 years or more 43
Adherence
Adherence Evaluations
Always 1401
Usually 284
Sometimes 41
Never taken as prescribed 56
Burden
Burden Evaluations
Very hard to take 59
Somewhat hard to take 106
A little hard to take 270
Not at all hard to take 1347
Cost per month
Cost per month Evaluations
$200+ 11
$100-199 21
$50-99 71
$25-49 147
< $25 868
Not specified 664

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 44
Venlafaxine (Effexor XR) 35
Fluoxetine (Prozac) 32
Duloxetine (Cymbalta) 27
Citalopram (Celexa) 19

Show all 35 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 26
Sertraline (Zoloft) 23
Venlafaxine (Effexor XR) 17
Bupropion (Wellbutrin XL) 13
Citalopram (Celexa) 12

Show all 33 treatments patients report switching to

Last updated:

183 patient evaluations for Bupropion

1,329 members have decided to share their profiles only with other members of PatientsLikeMe.

Keeper of the Flame
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Keeper of the Flame
Gender: F
Data Quality: 3 stars
Pain: Some
Fatigue: Some
Sleep: Most
Stiffness: Some
function: Some
external_stress: Little
Stickman: some
Description:F58y
CFS:?y
FM:8y Dx
I am: b
I have:
Fibromyalgia

See Keeper of the Flame's full Bupropion history

Oct 1, 2015 (Started Apr 27, 2012)

  • Effectiveness
    Slight (for Fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: I took the Bupropion until about January of 2015 and then I decided I had had just about enough of a bunch of meds that didn't work so I stopped taking them. Things went south in May 2015 when my Mother-In-Law died unexpectedly and so in April I started back on the Bupropion but my doctor also has me taking Provigil for my fatigue and I am doing a lot better now. I still don't know if the Bupropion is helping me or not. I am still tired a lost. Fatigued body and mind. (Sigh) Even with taking 200mg of Provigil a day. I guess I need more sleep but I don't think that will help any. Even when I get hours and hours of sleep the fatigue is still there. I take the bupropion in the mornings.
Cost: < $25 monthly

May 26, 2013 (Started Apr 27, 2012)

  • Effectiveness
    Can’t tell (for Fatigue)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Somewhat hard to take
Dosage: 500 mg Daily
Advice & Tips: I am very tired all of the time so my psychiatrist has prescribed this medication to see if it gives me any pep. I have been taking it for months now with no change in my exhaustion. As of Feb. 2013 I have been taking 300mg in the morning and 200mg in the afternoon. I forget to take the 200mg in the afternoon a lot of the time.
Cost: < $25 monthly

  • 0 helpful marks
ProfGumbySan
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ProfGumbySan
Sex: M
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See ProfGumbySan's full Bupropion history

Apr 14, 2015 (Started Jul 01, 2010)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 450 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
naomiah
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naomiah
Gender: F
Data Quality: 1 star
Depression: 1
Mania: 0
Emotional: 0
Anxiety: 1
Compulsion: 0
External Stress: Moderate
53 F
Function: High
Distress: Low
I am: g
I have:
Bipolar I

See naomiah's full Bupropion history

Feb 1, 2015 (Started Mar 01, 1990)

  • Effectiveness
    Slight (for Bipolar Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 450 mg Daily
Advice & Tips: I started Wellbutrin in 1989, before there was a generic. It worked very well for me until a couple of years ago, when I became convinced it was doing less for my depression, and more to make me anxious. My healthcare provider agreed that was a reasonable assessment. When I started Latuda, and it was a success, we decided to titrate off the Buproprion. I have not had difficulty since I quit it, although my anxiety level is still a little high.
Cost: < $25 monthly

Mar 17, 2010 (Started Mar 01, 1990)

  • Effectiveness
    Major (for Bipolar Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 150 mg/24 hours Daily
Cost: < $25 monthly

Mar 3, 2010 (Started Mar 01, 1990)

  • Effectiveness
    Major (for Bipolar Disorder)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 2 x 150 mg/24 hours Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 183 patient evaluations for Bupropion