What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 2,225 1,258
Depressed mood 1,595 782
Persistent depressive disorder (dysthymia) 386 316
Mild depression 152 65
Anxious mood 121 64

Show all 193 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
263
Moderate
374
Mild
603
None
1,100

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 104
Anxious mood 69
Weight gain 55
Insomnia 50
Headaches 47
Constipation 43

Show all 441 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 175
150 mg daily 140
100 mg daily 77
300 mg/24 hours daily 63
450 mg daily 52
75 mg daily 46
150 mg twice daily 33
100 mg twice daily 31
200 mg daily 27
150 mg/24 hours daily 25

See all 71 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 641
Side effects too severe 540
Doctor's advice 412
Other 271
Course of treatment ended 88
Expense 82
Personal research 70
Change in health plan coverage 42
See all 1561 patients who've stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 4
1 - 6 months 87
6 months - 1 year 68
1 - 2 years 108
2 - 5 years 198
5 - 10 years 185
10 years or more 170

Stopped taking Bupropion

Duration Patients
Less than 1 month 330
1 - 6 months 354
6 months - 1 year 244
1 - 2 years 224
2 - 5 years 272
5 - 10 years 120
10 years or more 56
Adherence
Adherence Evaluations
Always 1826
Usually 352
Sometimes 54
Never taken as prescribed 108
Burden
Burden Evaluations
Very hard to take 78
Somewhat hard to take 147
A little hard to take 337
Not at all hard to take 1778
Cost per month
Cost per month Evaluations
$200+ 13
$100-199 24
$50-99 84
$25-49 172
< $25 1130
Not specified 917

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 90
Fluoxetine (Prozac) 84
Venlafaxine (Effexor XR) 68
Citalopram (Celexa) 49
Duloxetine (Cymbalta) 47

Show all 55 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 46
Sertraline (Zoloft) 45
Venlafaxine (Effexor XR) 34
Citalopram (Celexa) 31
Fluoxetine (Prozac) 27

Show all 46 treatments patients report switching to

Last updated:

184 patient evaluations for Bupropion

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks

Aug 5, 2016 (Started Jul 01, 1979)

  • Effectiveness
    Slight (for major depressive disorder)
  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg One time

Jun 5, 2015 (Started Jul 01, 1979)

  • Effectiveness
    Major (for major depressive disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily
Advice & Tips: you need to talk to your Doctor about this treatment plan. some say it is to expense. I get my medIdecation from the VA

  • 0 helpful marks

Jun 28, 2016 (Started Aug 15, 2009)

  • Effectiveness
    Slight (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/24 hours Daily
Advice & Tips: I took this exclusively for two years and found minimal effects. I'm now on Celexa, as well, and the combination is working, but I suspect it's really all the Celexa.

  • 0 helpful marks
Last updated:
Showing 3 of 184 patient evaluations for Bupropion