What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major depressive disorder 2,299 1,297
Depressed mood 1,615 800
Persistent depressive disorder (dysthymia) 402 328
Mild depression 155 68
Anxious mood 121 66
Bipolar disorder 112 94

Show all 194 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 272
Moderate 380
Mild 616
None 1,140

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 107
Anxious mood 71
Weight gain 58
Insomnia 52
Headaches 48
Constipation 43

Show all 441 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 194
150 mg daily 147
300 mg/24 hours daily 66
100 mg daily 64
450 mg daily 55
75 mg daily 47
150 mg twice daily 38
200 mg daily 30
100 mg twice daily 29
150 mg/24 hours daily 27

See all 68 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 659
Side effects too severe 557
Doctor's advice 427
Other 281
Course of treatment ended 92
Expense 85
Personal research 73
Change in health plan coverage 44
See all 1613 patients who've stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 4
1 - 6 months 38
6 months - 1 year 102
1 - 2 years 114
2 - 5 years 229
5 - 10 years 197
10 years or more 168

Stopped taking Bupropion

Duration Patients
Less than 1 month 357
1 - 6 months 356
6 months - 1 year 235
1 - 2 years 231
2 - 5 years 283
5 - 10 years 127
10 years or more 64
Adherence
Adherence Evaluations
Always 1887
Usually 356
Sometimes 52
Never taken as prescribed 113
Burden
Burden Evaluations
Very hard to take 82
Somewhat hard to take 147
A little hard to take 341
Not at all hard to take 1838
Cost per month
Cost per month Evaluations
$200+ 15
$100-199 26
$50-99 86
$25-49 174
< $25 1160
Not specified 947

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 96
Fluoxetine (Prozac) 91
Venlafaxine (Effexor XR) 73
Citalopram (Celexa) 51
Duloxetine (Cymbalta) 48

Show all 56 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 52
Sertraline (Zoloft) 49
Venlafaxine (Effexor XR) 37
Citalopram (Celexa) 32
Fluoxetine (Prozac) 31

Show all 48 treatments patients report switching to

Last updated:

188 patient evaluations for Bupropion

Apr 15, 2017 (Started Jan 15, 2014)

  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I was told I would probably lose weight on this, but I didn't.
Cost: $25-49 monthly

Sep 15, 2014 (Started Jan 15, 2014)

  • Effectiveness
    Slight (for depressed mood)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Mar 9, 2017 (Started Jul 01, 2010)

  • Effectiveness
    Major (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: take as prescribed, Med reactivated in June 2017
Cost: < $25 monthly

  • 0 helpful marks

Feb 6, 2017 (Started Dec 04, 2009)

  • Effectiveness
    None (for tobacco use disorder)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Can't tell (for bipolar disorder)
  • Effectiveness
    Moderate (for anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I continue taking Wellbutrin daily in the morning. I have many helpful strategies for reducing anxiety. Pair those coping skills with this medication, I have been able to avoid the benzodiazepines. I initially asked Pdoc for this med to assist my stop smoking nicotine efforts. The effects of the anti-anxiety component were noticeable behaviorally: symptoms reduced and intensity of symptoms lessened. As far as helping with my depression, I have been without an episode of major depression for as long as I have been taking Wellbutrin. I don't allocate all credit to this med. I take Trintellix also.I have noticed a more consistent level of lower anxiety on Wellbutrin.
Cost: < $25 monthly

Nov 29, 2015 (Started Dec 04, 2009)

  • Effectiveness
    None (for tobacco use disorder)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Moderate (for bipolar disorder)
  • Effectiveness
    Moderate (for anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: Just wanting to update. I continue taking Wellbutrin daily in the morning. I have many helpful strategies for reducing anxiety. Pair those coping skills with this medication, I have been able to avoid the benzodiazepines.
Cost: < $25 monthly

Apr 6, 2011 (Started Dec 04, 2009)

  • Effectiveness
    Can't tell (for bipolar disorder)
  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Moderate (for anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I initially asked Pdoc for this med to assist my stop smoking nicotine efforts. The effects of the anti-anxiety component were noticeable behaviorally: symptoms reduced and intensity of symptoms lessened. As far as helping with my depression, I have been without an episode of major depression for as long as I have been taking wellbutrin. I don't allocate all credit to this med. I take Pristiq also. So, did it help me quit smoking? not yet.
Cost: < $25 monthly

Oct 25, 2010 (Started Dec 04, 2009)

  • Effectiveness
    Can't tell (for bipolar disorder)
  • Effectiveness
    Slight (for depressed mood)
  • Effectiveness
    Moderate (for anxious mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg Daily
Advice & Tips: I have noticed a more consistent level of lower anxiety on Wellbutrin. It has also noticeably helped decrease the depression a degree during episodes. I have also decreased my tabacco intake since taking .
Cost: < $25 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 188 patient evaluations for Bupropion