What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
major depressive disorder 2,086 1,196
Depressed mood 1,555 752
persistent depressive disorder (dysthymia) 366 304
mild depression 147 61
Anxious mood 120 64
bipolar disorder 105 91

Show all 213 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 249
Moderate 364
Mild 581
None 1,053

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 101
Anxious mood 64
Weight gain 54
Insomnia 49
Headaches 47
Constipation 41

Show all 429 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 173
150 mg daily 156
100 mg daily 105
75 mg daily 62
300 mg/24 hours daily 62
450 mg daily 57
150 mg twice daily 42
100 mg twice daily 37
200 mg daily 27
150 mg/24 hours daily 21

See all 86 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 608
Side effects too severe 511
Doctor's advice 395
Other 265
Course of treatment ended 85
Expense 80
Personal research 71
Change in health plan coverage 39
See all 1490 patients who've stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 17
1 - 6 months 77
6 months - 1 year 81
1 - 2 years 140
2 - 5 years 241
5 - 10 years 203
10 years or more 172

Stopped taking Bupropion

Duration Patients
Less than 1 month 306
1 - 6 months 346
6 months - 1 year 239
1 - 2 years 212
2 - 5 years 258
5 - 10 years 114
10 years or more 55
Adherence
Adherence Evaluations
Always 1756
Usually 340
Sometimes 49
Never taken as prescribed 102
Burden
Burden Evaluations
Very hard to take 75
Somewhat hard to take 141
A little hard to take 331
Not at all hard to take 1700
Cost per month
Cost per month Evaluations
$200+ 13
$100-199 25
$50-99 84
$25-49 167
< $25 1087
Not specified 871

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 84
Fluoxetine (Prozac) 77
Venlafaxine (Effexor XR) 61
Citalopram (Celexa) 43
Duloxetine (Cymbalta) 43

Show all 53 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 44
Sertraline (Zoloft) 40
Venlafaxine (Effexor XR) 29
Citalopram (Celexa) 26
Fluoxetine (Prozac) 24

Show all 44 treatments patients report switching to

Last updated:

185 patient evaluations for Bupropion

Jan 13, 2017 (Started Dec 06, 2016)

  • Effectiveness
    Slight (for Lack of motivation)
  • Effectiveness
    Slight (for Exhaustion)
  • Effectiveness
    Slight (for Excessive sleeping (hypersomnia))
  • Side effects
    Moderate (Muscle twitching (fasciculations), Impulsive behaviors)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 75 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Nov 1, 2016 (Started Aug 19, 2016)

  • Effectiveness
    None (for persistent depressive disorder (dysthymia))
  • Side effects
    Severe (Serotonin syndrome, Night sweats, Unrefreshing or poor sleep, Constipation, Shakiness, Hot flashes, Brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily

  • 0 helpful marks

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for bipolar II disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 185 patient evaluations for Bupropion