What is Bupropion?

Category: Prescription Drugs

Most popular types: Wellbutrin XL Wellbutrin Bupropion XL Show all

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Bupropion, a norepinephrine and dopamine reuptake inhibitor (NDRI) antidepressant is used for the treatment of major depressive disorder, including seasonal affective disorder, and as an adjunct in smoking cessation. It may also be used for attention-deficit/hyperactivity and bipolar disorders.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Major Depressive Disorder 2,012 1,162
Depressed mood 1,544 744
Persistent depressive disorder (dysthymia) 357 296
Mild Depression 144 59
Anxious mood 117 59
Bipolar Disorder 105 91

Show all 210 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 244
Moderate 354
Mild 577
None 1,028

Commonly reported side effects and conditions associated with Bupropion

Side effect Patients
Dry mouth 101
Anxious mood 60
Weight gain 53
Insomnia 49
Headaches 48
Constipation 41

Show all 426 reported side effects

Dosages

Based on patients currently taking Bupropion

Dosage Patients
300 mg daily 164
150 mg daily 149
100 mg daily 103
300 mg/24 hours daily 72
75 mg daily 58
450 mg daily 49
100 mg twice daily 42
150 mg twice daily 38
200 mg daily 27
150 mg/24 hours daily 25

See all 84 dosages

Why patients stopped taking Bupropion

Multiple reasons could be selected

Reason Patients
Did not seem to work 600
Side effects too severe 500
Doctor's advice 386
Other 261
Course of treatment ended 84
Expense 81
Personal research 69
Change in health plan coverage 39
See all 1464 patients who’ve stopped taking Bupropion

Duration

Currently taking Bupropion

Duration Patients
Less than 1 month 10
1 - 6 months 88
6 months - 1 year 103
1 - 2 years 151
2 - 5 years 201
5 - 10 years 194
10 years or more 162

Stopped taking Bupropion

Duration Patients
Less than 1 month 298
1 - 6 months 343
6 months - 1 year 236
1 - 2 years 209
2 - 5 years 252
5 - 10 years 113
10 years or more 53
Adherence
Adherence Evaluations
Always 1718
Usually 337
Sometimes 48
Never taken as prescribed 100
Burden
Burden Evaluations
Very hard to take 74
Somewhat hard to take 140
A little hard to take 329
Not at all hard to take 1660
Cost per month
Cost per month Evaluations
$200+ 13
$100-199 25
$50-99 84
$25-49 163
< $25 1066
Not specified 852

What people switch to and from

Patients started taking Bupropion after stopping:

Treatment Patients
Sertraline (Zoloft) 77
Fluoxetine (Prozac) 70
Venlafaxine (Effexor XR) 59
Citalopram (Celexa) 41
Duloxetine (Cymbalta) 40

Show all 50 treatments patients report switching from

Patients stopped taking Bupropion and switched to:

Treatment Patients
Duloxetine (Cymbalta) 43
Sertraline (Zoloft) 38
Venlafaxine (Effexor XR) 28
Citalopram (Celexa) 22
Fluoxetine (Prozac) 22

Show all 42 treatments patients report switching to

Last updated:

186 patient evaluations for Bupropion

1,695 members have decided to share their profiles only with other members of PatientsLikeMe.

CupcakeKitten
76997 thumb
CupcakeKitten
Gender: F
Data Quality: 3 stars
Depression: 1
Mania: 0
Emotional: 2
Anxiety: 1
Compulsion: 0
External Stress: Severe
25 F
Function: Moderate
Distress: Low
I am: g
I have:
Borderline Personality

See CupcakeKitten's full Bupropion history

Jan 13, 2017 (Started Dec 06, 2016)

  • Effectiveness
    Slight (for Lack of motivation)
  • Effectiveness
    Slight (for Exhaustion)
  • Effectiveness
    Slight (for Excessive sleeping (hypersomnia))
  • Side effects
    Moderate (Muscle twitching (fasciculations), Impulsive behaviors)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 75 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
gridly1
27338 thumb
gridly1
Gender: F
Data Quality: 1 star
Pain: Little
Fatigue: Some
Sleep: All
Stiffness: All
function: None
external_stress: Most
Stickman: most
Description:F57y
CFS:?y
FM:8y Dx
I am: b
I have:
ME/CFS

See gridly1's full Bupropion history

Nov 1, 2016 (Started Aug 19, 2016)

  • Effectiveness
    None (for Persistent depressive disorder (dysthymia))
  • Side effects
    Severe (Serotonin syndrome, Night sweats, Unrefreshing or poor sleep, Constipation, Shakiness, Hot flashes, Brain fog)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 150 mg Daily

  • 0 helpful marks
ProfGumbySan
11668 thumb
ProfGumbySan
Sex: M
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See ProfGumbySan's full Bupropion history

Aug 31, 2016 (Started Sep 10, 1997)

  • Effectiveness
    None (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Oct 23, 2015 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: < $25 monthly

Jun 1, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Bipolar II Disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Been back on Wellbutrin 450mg/day for a couple of ears now and, with the addition of 20mg/day of Viibryd I've been very stable.
Cost: < $25 monthly

Mar 11, 2009 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Cost: $25-49 monthly

Aug 27, 2008 (Started Sep 10, 1997)

  • Effectiveness
    Major (for Other)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 150 mg/24 hours Daily
Advice & Tips: Like any antidepressant, you (doctor & patient) have to determine what works for you. I was on various doses of Prozac for several years, but its effect eventually wore off. My psychopharmacologist switched me to Wellbutrin in 1997 and I've been on various doses of it since. Wellbutrin works on the dopamine system in the brain, so I'm curious how it relates to PD (if it does at all).
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 186 patient evaluations for Bupropion