What is Intravenous Immunoglobulin (IVIG)?

Category: Prescription Drugs

Most popular types: Gammaglobulin (IVIg) Gammagard Gamunex Show all

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Intravenous Immune Globulin (IVIG) is a human blood product consisting of antibodies which is used to treat immunodeficiency disorders, B-cell chronic lymphocytic leukemia, inflammatory demyelinating disorders. It may also be used to treat Guillain-Barré, Multiple Sclerosis, and myasthenia gravis.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 73 54
Chronic inflammatory demyelinating polyneuropathy 58 37
Hypogammaglobulinemia 52 48
Myasthenia gravis 51 30
Common variable immunodeficiency disorder 42 31
Multifocal motor neuropathy 21 17

Show all 102 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 37
Moderate 70
Mild 125
None 87

Commonly reported side effects and conditions associated with Intravenous Immunoglobulin (IVIG)

Side effect Patients
Headaches 86
Fatigue 26
Nausea 26
Migraine headaches 22
Fever/chills 9
Aseptic meningitis 8

Show all 123 reported side effects

Dosages

Based on patients currently taking Intravenous Immunoglobulin (IVIG)

Dosage Patients
30 g monthly 3
40 g monthly 3
1 other monthly 2
10 g monthly 2
30 mg monthly 2
100 mg monthly 2
50 mg every other week 2
90 g every other week 2
10,000 mg weekly 2
1 L monthly 1

See all 44 dosages

Why patients stopped taking Intravenous Immunoglobulin (IVIG)

Multiple reasons could be selected

Reason Patients
Did not seem to work 75
Course of treatment ended 69
Doctor's advice 52
Side effects too severe 37
Other 30
Change in health plan coverage 16
Expense 14
Personal research 4
See all 217 patients who've stopped taking Intravenous Immunoglobulin (IVIG)

Duration

Currently taking Intravenous Immunoglobulin (IVIG)

Duration Patients
Less than 1 month 2
1 - 6 months 5
6 months - 1 year 6
1 - 2 years 9
2 - 5 years 17
5 - 10 years 9
10 years or more 10

Stopped taking Intravenous Immunoglobulin (IVIG)

Duration Patients
Less than 1 month 77
1 - 6 months 55
6 months - 1 year 28
1 - 2 years 25
2 - 5 years 27
5 - 10 years 9
10 years or more 3
Adherence
Adherence Evaluations
Always 281
Usually 12
Sometimes 3
Never taken as prescribed 23
Burden
Burden Evaluations
Very hard to take 38
Somewhat hard to take 106
A little hard to take 88
Not at all hard to take 87
Cost per month
Cost per month Evaluations
$200+ 59
$100-199 6
$50-99 2
$25-49 9
< $25 88
Not specified 155

What people switch to and from

Patients started taking Intravenous Immunoglobulin (IVIG) after stopping:

Treatment Patients
Mycophenolate mofetil (CellCept) 4
Subcutaneous immune globulin (Hizentra) 4
Azathioprine (Imuran) 3
Methotrexate (Apo-Methotrexate) 3
Methylprednisolone (Solu-Medrol Infusion) 3

Show all 17 treatments patients report switching from

Patients stopped taking Intravenous Immunoglobulin (IVIG) and switched to:

Treatment Patients
Subcutaneous immune globulin (Hizentra) 13
Rituximab (Rituxan) 3
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 2
Riluzole (Rilutek) 2
Cyclophosphamide (Cytoxan) 1

Show all 12 treatments patients report switching to

Last updated:

18 patient evaluations for Intravenous Immunoglobulin (IVIG)

Apr 6, 2018 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 g Monthly
Advice & Tips: Continuing to infuse the D5NS with my Gammagard. It makes a huge difference with my side effects. I also don't gain as much weight, however I have to make sure to not take my diuretics for a couple days afterwards or else I get a massive headache.

Jan 16, 2017 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 g Monthly
Advice & Tips: My 12/6/16 infusion had a lot fewer side effects the next day and also the night of. My new immunologist had D5NS infuse at 20 mL/hr in addition to the Gammagard Liquid at my maximum tolerable rate of 40 mL/hr. Having the D5NS really seemed to make a big difference in the decreased side effects. Basically I was just really fatigued for a couple days.

Aug 27, 2016 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 g Monthly
Advice & Tips: With the Gammagard, I have noticed that my weight jumps about 9 pounds after each infusion. The weight change takes place overnight and after about 7 days, my weight is back to baseline. My insurance requires a new prior authorization every 3 months, which makes it something else that I have to keep tabs on. 

Nov 16, 2015 (Started Nov 12, 2015)

  • Effectiveness
    Can't tell (for hypogammaglobulinemia)
  • Side effects
    Moderate (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 25 g Monthly

  • 1 helpful mark

Apr 15, 2017 (Started Mar 08, 2017)

  • Effectiveness
    Can't tell (for hypogammaglobulinemia)
  • Side effects
    Severe (aseptic meningitis)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 35000 mg Monthly
Cost: < $25 monthly

  • 0 helpful marks

Nov 1, 2015 (Started May 15, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Moderate (abdominal pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25000 mg Monthly

  • 0 helpful marks
Last updated:
Showing 3 of 18 patient evaluations for Intravenous Immunoglobulin (IVIG)