What is Intravenous Immunoglobulin (IVIG)?

Category: Prescription Drugs

Most popular types: Gammaglobulin (IVIg) Gammagard Gamunex Show all

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Intravenous Immune Globulin (IVIG) is a human blood product consisting of antibodies which is used to treat immunodeficiency disorders, B-cell chronic lymphocytic leukemia, inflammatory demyelinating disorders. It may also be used to treat Guillain-Barré, Multiple Sclerosis, and myasthenia gravis.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 73 52
Chronic inflammatory demyelinating polyneuropathy 56 33
Hypogammaglobulinemia 50 46
Myasthenia gravis 48 26
Common variable immunodeficiency disorder 42 33
Multifocal motor neuropathy 19 16

Show all 104 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe
34
Moderate
66
Mild
119
None
86

Commonly reported side effects and conditions associated with Intravenous Immunoglobulin (IVIG)

Side effect Patients
Headaches 83
Nausea 24
Fatigue 23
Migraine headaches 21
Flu like symptoms 12
Fever/chills 8

Show all 152 reported side effects

Dosages

Based on patients currently taking Intravenous Immunoglobulin (IVIG)

Dosage Patients
30 g monthly 3
30 mg monthly 3
100 mg monthly 3
10 g every other week 2
20 g every other week 2
100 mg every 6 weeks 2
50 mg every other week 2
10,000 mg weekly 2
1 other monthly 1
1 other every 3 weeks 1

See all 57 dosages

Why patients stopped taking Intravenous Immunoglobulin (IVIG)

Multiple reasons could be selected

Reason Patients
Did not seem to work 74
Course of treatment ended 68
Doctor's advice 52
Side effects too severe 36
Other 29
Change in health plan coverage 15
Expense 14
Personal research 4
See all 212 patients who've stopped taking Intravenous Immunoglobulin (IVIG)

Duration

Currently taking Intravenous Immunoglobulin (IVIG)

Duration Patients
1 - 6 months 6
6 months - 1 year 9
1 - 2 years 13
2 - 5 years 24
5 - 10 years 8
10 years or more 13

Stopped taking Intravenous Immunoglobulin (IVIG)

Duration Patients
Less than 1 month 74
1 - 6 months 53
6 months - 1 year 27
1 - 2 years 24
2 - 5 years 28
5 - 10 years 10
10 years or more 3
Adherence
Adherence Evaluations
Always 271
Usually 10
Sometimes 3
Never taken as prescribed 21
Burden
Burden Evaluations
Very hard to take 37
Somewhat hard to take 101
A little hard to take 83
Not at all hard to take 84
Cost per month
Cost per month Evaluations
$200+ 58
$100-199 6
$50-99 2
$25-49 8
< $25 86
Not specified 145

What people switch to and from

Patients started taking Intravenous Immunoglobulin (IVIG) after stopping:

Treatment Patients
Azathioprine (Imuran) 3
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 3
Methotrexate (Apo-Methotrexate) 3
Methylprednisolone (Solu-Medrol Infusion) 3
Mycophenolate mofetil (CellCept) 3

Show all 17 treatments patients report switching from

Patients stopped taking Intravenous Immunoglobulin (IVIG) and switched to:

Treatment Patients
Subcutaneous immune globulin (Hizentra) 13
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 3
Rituximab (Rituxan) 3
Cyclophosphamide (Cytoxan) 1
Methotrexate (Apo-Methotrexate) 1

Show all 12 treatments patients report switching to

Last updated:

18 patient evaluations for Intravenous Immunoglobulin (IVIG)

Apr 15, 2017 (Started Mar 08, 2017)

  • Effectiveness
    Can't tell (for hypogammaglobulinemia)
  • Side effects
    Severe (aseptic meningitis)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 35000 mg Monthly
Cost: < $25 monthly

  • 0 helpful marks

Jan 16, 2017 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Monthly
Advice & Tips: My 12/6/16 infusion had a lot fewer side effects the next day and also the night of. My new immunologist had D5NS infuse at 20 mL/hr in addition to the Gammagard Liquid at my maximum tolerable rate of 40 mL/hr. Having the D5NS really seemed to make a big difference in the decreased side effects. Basically I was just really fatigued for a couple days.

Aug 27, 2016 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 g Monthly
Advice & Tips: With the Gammagard, I have noticed that my weight jumps about 9 pounds after each infusion. The weight change takes place overnight and after about 7 days, my weight is back to baseline. My insurance requires a new prior authorization every 3 months, which makes it something else that I have to keep tabs on. 

Nov 16, 2015 (Started Nov 12, 2015)

  • Effectiveness
    Can't tell (for hypogammaglobulinemia)
  • Side effects
    Moderate (weight gain, abdominal pain, migraine, fatigue)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 25 g Monthly

  • 1 helpful mark

Nov 1, 2015 (Started May 15, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Moderate (abdominal pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25000 mg Monthly

  • 0 helpful marks
Last updated:
Showing 3 of 18 patient evaluations for Intravenous Immunoglobulin (IVIG)