What is Dornase alfa?

Category: Prescription Drugs

Most popular types: Pulmozyme

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Dornase alfa is an enzyme used with cystic fibrosis patients to reduce the frequency of respiratory infections that require IV antibiotics; in conjunction with standard therapies, it is used to improve pulmonary function in patients with cystic fibrosis.

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 0
Moderate 2
Mild 0
None 10

Commonly reported side effects and conditions associated with Dornase alfa

Side effect Patients
Coughing up blood (hemoptysis) 1
Sore throat 1

Dosages

Based on patients currently taking Dornase alfa

Dosage Patients
2.5 mg/2.5 mL daily 3
2 x 2.5 mg/2.5 mL daily 2
1 mg twice daily 1
2 mg twice daily 1
5 mg twice daily 1

Why patients stopped taking Dornase alfa

Multiple reasons could be selected

Reason Patients
Change in health plan coverage 3
Did not seem to work 3
Doctor's advice 2
Side effects too severe 2
Course of treatment ended 1
Other 1
See all 11 patients who've stopped taking Dornase alfa

Duration

Currently taking Dornase alfa

Duration Patients
2 - 5 years 3
5 - 10 years 1
10 years or more 4

Stopped taking Dornase alfa

Duration Patients
Less than 1 month 1
1 - 6 months 3
6 months - 1 year 1
1 - 2 years 1
2 - 5 years 1
5 - 10 years 2
10 years or more 2
Adherence
Adherence Evaluations
Always 8
Usually 4
Sometimes 0
Never taken as prescribed 0
Burden
Burden Evaluations
Very hard to take 0
Somewhat hard to take 2
A little hard to take 4
Not at all hard to take 6

What people switch to and from

Patients started taking Dornase alfa after stopping:

Treatment Patients
Hypertonic Saline (MucoClear) 1
Last updated:

3 patient evaluations for Dornase alfa

Jul 1, 2014 (Started Jul 01, 2013)

  • Effectiveness
    Major (for cystic fibrosis)
  • Side effects
    Moderate (coughing up blood (hemoptysis))
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1 mg Twice daily
Advice & Tips: noticed with lower lung capacity that bleeding started more frequently. it also seemed to be more severe if I would do a treatment at night and not clear all of it out of my lungs. residual med would sit in my lungs while I slept, which would cause a lot of bleeding the following morning. We found that lowering the dose to just the mornings or not taking before bed would help, but eventually this became to persistent for me to continue it.

  • 0 helpful marks

Sep 28, 2012 (Started Nov 12, 2009)

  • Effectiveness
    Major (for increased secretions)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 2 x 2.5 mg/2.5 mL Daily
Advice & Tips: took a long time to do.

Feb 20, 2011 (Started Nov 12, 2009)

  • Effectiveness
    Major (for increased secretions)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 2.5 mg/2.5 mL Daily

  • 0 helpful marks

Feb 1, 2009 (Started Jan 01, 1998)

  • Effectiveness
    Major (for cystic fibrosis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 2.5 mg/2.5 mL Daily

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Dornase alfa