What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's Disease 2,480 1,491
Stiffness/Spasticity 111 73
MSA (Multiple System Atrophy) 79 53
RLS (Restless Legs Syndrome) 68 45
Tremor(s) 58 56
Slowness 48 32

Show all 98 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 72
Moderate 320
Mild 504
None 703

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 144
Nausea 119
Drowsiness 43
Constipation 26
Upset stomach 24
Headaches 23

Show all 298 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 51
25 mg-100 mg three times daily 40
3 x 25 mg-100 mg daily 29
25-100 mg four times daily 27
2 x 25-100 mg three times daily 23
4 x 25 mg-100 mg daily 21
25 mg-100 mg four times daily 17
6 x 25 mg-100 mg daily 17
25-100 mg five times daily 16
2 x 25-100 mg four times daily 14

See all 172 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 125
Did not seem to work 96
Side effects too severe 80
Other 70
Personal research 28
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 343 patients who’ve stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
1 - 6 months 29
6 months - 1 year 48
1 - 2 years 90
2 - 5 years 196
5 - 10 years 195
10 years or more 67

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 37
1 - 6 months 83
6 months - 1 year 55
1 - 2 years 59
2 - 5 years 82
5 - 10 years 39
10 years or more 5
Adherence
Adherence Evaluations
Always 1169
Usually 348
Sometimes 39
Never taken as prescribed 43
Burden
Burden Evaluations
Very hard to take 55
Somewhat hard to take 266
A little hard to take 403
Not at all hard to take 875
Cost per month
Cost per month Evaluations
$200+ 12
$100-199 21
$50-99 62
$25-49 142
< $25 889
Not specified 473

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 34
Pramipexole (Mirapex) 25
Carbidopa-Entacapone-Levodopa (Stalevo) 17
Rasagiline (Azilect) 15
Amantadine (Symmetrel) 13

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 40
Carbidopa-Entacapone-Levodopa (Stalevo) 10
Carbidopa-Levodopa CR (Sinemet CR) 6
Pramipexole (Mirapex) 6
Ropinirole (Requip) 6

Show all 17 treatments patients report switching to

Last updated:

128 patient evaluations for Carbidopa-Levodopa

1,007 members have decided to share their profiles only with other members of PatientsLikeMe.

margie99
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margie99
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See margie99's full Carbidopa-Levodopa history

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Moderate (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit.
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Moderate (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks
reikihh
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reikihh
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See reikihh's full Carbidopa-Levodopa history

Jan 12, 2017 (Started Jun 30, 2004)

  • Effectiveness
    Major (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I am so afraid of increasing my dose of carbidopa/levadopa that I still have not even tried it. I might be able to move better if I increased it but I fear the nausea, the dyskinesia, the near syncope. However, I have such back pain that it interferes with everythingI want to do. I can only walk for a short time before I am looking for a place to sit. That eliminates any tours, any walks in the woods. I used to enjoy walking. And I have gained a lot of weight from being sedentary.
Cost: < $25 monthly

Apr 24, 2016 (Started Jun 30, 2004)

  • Effectiveness
    Can’t tell (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: The carbidopa/levodopa works the best for me to lessen the symptoms of PD. Other Rx drugs I tried didn't work as well or they worked well for symptoms but caused syncope or near syncope and left me feeling drained. It took many months to find the right med & the right dose. I do realize that carb/levo may cause tardive dyskinesia before it's over. But right now it is the best I can do & I want to enjoy it while I can. I can do quite a bit still . I owe that to the carb/levo.
Cost: < $25 monthly

Nov 26, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Very hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: My niece showed me how to set my iPhone clock to have a timer go off every day at 1pm to remind me to take my mid day dose of carb/levo & pramipexole. It works!!! It has worked. I have not missed a day since using the timer. I now am aware of "wearing off" of the meds. I never noticed it until a few months ago. At my last appt with Neurologist he increased my carb/levo to 1 1/2 TID. He said to increase gradually. I haven't increased just yet because I want to be firmly on the previous dose first which I am with this timer helping me. Soon I will try the new increase.
Cost: < $25 monthly

Jun 5, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Can’t tell (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: Now I am taking a new dose-1 TID-gradually titrating up from 1/2 TID. I still miss my noon dose although not as often. It is difficult remembering. I do notice the increase in dose is helping me stand up straighter longer & within about an hour of taking my dose. It is a pain in the neck to take 3 x a day but it improves my symptoms.
Cost: < $25 monthly

Feb 11, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Major (for RLS (Restless Legs Syndrome))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I no longer am seeing any improvement. Maybe I have just gotten used to it & no longer notice it. Maybe it is time to increase again.
Cost: < $25 monthly

Nov 10, 2014 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: This formula (immediate release) was given so I can see if I can get more carb/levo into me for better symptom control, but the problem with this formula is that I have a hard time remembering the noon dose. I am having an easier time remembering it now that I am retired, but I still forget sometimes. So far I MAY have experienced improvement in symptoms: I occasionally get relief from my back pain. I think the pain is caused by the postural changes with PD & anything I do to correct posture relieves the pain. This 1/2 pill taken 3x a day gives me more levo than I was getting with the CR 50/200 1/2 daily. Just that small amt more seems to have helped me stand up better which relieves the pain.
Cost: < $25 monthly

  • 0 helpful marks
TamiLynn
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TamiLynn
Sex: F
Data Quality: 2 stars
Off
Mouth/throat: none
Arms: mild
Chest: none
Legs: mild
I am: vg
I have:
Parkinson's

See TamiLynn's full Carbidopa-Levodopa history

Jan 3, 2017 (Started Jun 23, 2006)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 mg Daily
Cost: $100-199 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 128 patient evaluations for Carbidopa-Levodopa