What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's Disease 2,565 1,566
Stiffness/Spasticity 111 75
MSA (Multiple System Atrophy) 81 54
RLS (Restless Legs Syndrome) 73 50
Tremor(s) 58 57
Slowness (bradykinesia) 53 35

Show all 97 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 74
Moderate 334
Mild 528
None 747

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements (dyskinesia) 147
Nausea 123
Drowsiness 44
Constipation 26
Upset stomach 24
Headaches 23

Show all 308 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 57
25 mg-100 mg three times daily 34
3 x 25 mg-100 mg daily 30
25-100 mg four times daily 28
2 x 25-100 mg three times daily 21
25 mg-100 mg four times daily 20
25-100 mg five times daily 18
4 x 25 mg-100 mg daily 17
25 mg-100 mg daily 15
25 mg-100 mg five times daily 13

See all 173 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 126
Did not seem to work 100
Side effects too severe 82
Other 71
Personal research 29
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 349 patients who’ve stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 1
1 - 6 months 31
6 months - 1 year 54
1 - 2 years 96
2 - 5 years 211
5 - 10 years 182
10 years or more 76

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 36
1 - 6 months 86
6 months - 1 year 55
1 - 2 years 59
2 - 5 years 85
5 - 10 years 40
10 years or more 5
Adherence
Adherence Evaluations
Always 1230
Usually 365
Sometimes 40
Never taken as prescribed 48
Burden
Burden Evaluations
Very hard to take 56
Somewhat hard to take 279
A little hard to take 411
Not at all hard to take 937
Cost per month
Cost per month Evaluations
$200+ 13
$100-199 21
$50-99 66
$25-49 153
< $25 936
Not specified 494

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 40
Pramipexole (Mirapex) 27
Carbidopa-Entacapone-Levodopa (Stalevo) 18
Rasagiline (Azilect) 17
Amantadine (Symmetrel) 16

Show all 16 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 42
Carbidopa-Entacapone-Levodopa (Stalevo) 10
Carbidopa-Levodopa CR (Sinemet CR) 7
Ropinirole (Requip) 7
Pramipexole (Mirapex) 6

Show all 18 treatments patients report switching to

Last updated:

129 patient evaluations for Carbidopa-Levodopa

1,055 members have decided to share their profiles only with other members of PatientsLikeMe.

garden35
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garden35
Sex: M
Data Quality: 3 stars
On
Mouth/throat: none
Arms: none
Chest: none
Legs: none
I am: vg
I have:
Parkinson's

See garden35's full Carbidopa-Levodopa history

Mar 22, 2017 (Started Aug 18, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 9, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Jun 16, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 22, 2015 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Nov 21, 2013 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 6, 2012 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 5, 2011 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
J.Marley
20395 thumb
J.Marley
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See J.Marley's full Carbidopa-Levodopa history

Feb 3, 2017 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Nov 28, 2016 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Dec 15, 2015 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: This summer I had to lower my total intake of carbidopa / levodopa as I began to experience dyskinesia in the evenings.  If I keep my daily levodopa dose at or below 1200 mgs, I seldom experience any dyskinesia.
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Dec 17, 2012 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Advice & Tips: I take the regular Sinemet pill as a 'back-up' to my extended release Sinemet when I go to the gym, paint or do something during which time I hope to lesson my tremors - it does seem to help.
Cost: < $25 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jul 6, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jun 30, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jun 29, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

  • 0 helpful marks
margie99
70573 thumb
margie99
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See margie99's full Carbidopa-Levodopa history

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Moderate (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit.
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Moderate (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 129 patient evaluations for Carbidopa-Levodopa