What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2,843 1,866
Stiffness/spasticity 111 83
Multiple system atrophy 86 58
Restless legs syndrome 80 61
Tremor(s) 60 57
Slow movement (bradykinesia) 53 36

Show all 92 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 87
Moderate 393
Mild 610
None 895

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients
Jerky movements 162
Nausea 140
Drowsiness 48
Constipation 32
Upset stomach 26
Headaches 25

Show all 344 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients
25-100 mg three times daily 79
25-100 mg four times daily 41
25 mg-100 mg three times daily 33
3 x 25 mg-100 mg daily 32
2 x 25-100 mg three times daily 26
25-100 mg five times daily 25
4 x 25 mg-100 mg daily 23
6 x 25 mg-100 mg daily 20
25 mg-100 mg daily 19
25-100 mg twice daily 15

See all 211 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients
Doctor's advice 136
Did not seem to work 112
Side effects too severe 98
Other 74
Personal research 31
Course of treatment ended 19
Change in health plan coverage 7
Expense 5
See all 381 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 3
1 - 6 months 21
6 months - 1 year 46
1 - 2 years 101
2 - 5 years 236
5 - 10 years 276
10 years or more 108

Stopped taking Carbidopa-Levodopa

Duration Patients
Less than 1 month 48
1 - 6 months 90
6 months - 1 year 55
1 - 2 years 62
2 - 5 years 94
5 - 10 years 41
10 years or more 9
Adherence
Adherence Evaluations
Always 1454
Usually 422
Sometimes 48
Never taken as prescribed 61
Burden
Burden Evaluations
Very hard to take 61
Somewhat hard to take 310
A little hard to take 497
Not at all hard to take 1117
Cost per month
Cost per month Evaluations
$200+ 18
$100-199 23
$50-99 68
$25-49 172
< $25 1113
Not specified 591

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients
Ropinirole (Requip) 46
Pramipexole (Mirapex) 42
Rasagiline (Azilect) 26
Amantadine (Symmetrel) 21
Carbidopa-Entacapone-Levodopa (Stalevo) 19

Show all 18 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients
Carbidopa Levodopa ER (Rytary XR) 64
Carbidopa-Entacapone-Levodopa (Stalevo) 14
Ropinirole (Requip) 13
Carbidopa-Levodopa CR (Sinemet CR) 10
Pramipexole (Mirapex) 10

Show all 21 treatments patients report switching to

Last updated:

134 patient evaluations for Carbidopa-Levodopa

May 22, 2018 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: all the same
Cost: < $25 monthly
Side effects: jerky movements

Dec 21, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

May 1, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: suddenly became more dyskinetic and realized it was important to cut back on amount
Cost: < $25 monthly
Side effects: jerky movements

Feb 18, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Jan 17, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Aug 19, 2008 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Other)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 800 mg Daily
Advice & Tips: use exactly as directed to avoid side effects
Cost: < $25 monthly
Side effects: jerky movements

  • 1 helpful mark

Apr 11, 2018 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for dystonia)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 25-100 mg Five times daily
Cost: < $25 monthly

Nov 4, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for dystonia)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 25-100 mg Five times daily
Advice & Tips: must eat carbs before taking medicine so I don't get sick to my stomach.
Cost: < $25 monthly

Aug 10, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for dystonia)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 25-100 mg Five times daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit. I take 2 tablets times 4 times daily of the 25/100 mg. tablets
Cost: < $25 monthly

May 25, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Moderate (for dystonia)
  • Side effects
    Moderate (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 2 x 25-100 mg Five times daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit. I take 2 tablets times 4 times daily of the 25/100 mg. tablets
Cost: < $25 monthly

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Moderate (for dystonia)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit.
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Slight (for dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Slight (for dystonia)
  • Side effects
    Mild (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Slight (for dystonia)
  • Side effects
    Moderate (nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks

Mar 28, 2018 (Started Mar 15, 2005)

  • Effectiveness
    Slight (for dystonia)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I AM ON RYTARY 48.75MG/195MG NOT XR. THIS MEDICATION IS ONLY SLIGHTLY WORKING. I WAS ON STALEVO 200MG WHICH WORKED GREAT FOR 9 YEARS. THEN IT WORE OFF QUICKLY AND I WAS PUT ON RYTARY.
Cost: $100-199 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 134 patient evaluations for Carbidopa-Levodopa