What is Natalizumab?

Category: Prescription Drugs

Most popular types: Tysabri Antegren

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Natalizumab is a monoclonal antibody given by infusion and used in the treatment of MS and Crohn's disease. It has been shown to slow progression and reduce relapses in MS. 

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 2,094 1,445
Improve mobility 49 40
General health 32 20
Fatigue 26 18
Stiffness/spasticity 20 15
Nerve pain (neuralgia) 9 12

Show all 29 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 78
Moderate 131
Mild 415
None 844

Commonly reported side effects and conditions associated with Natalizumab

Side effect Patients
Headaches 94
Fatigue 65
Tiredness 64
Nausea 20
Head pain 11
Stomach pain 11

Show all 217 reported side effects

Dosages

Based on patients currently taking Natalizumab

Dosage Patients
300 mg/15 mL monthly 77
300 mg/15 mL every 4 weeks 65
300 mg/15ml every 4 weeks 36
300 mg/15ml monthly 23
monthly 5
300 mg/15 mL every 6 weeks 3
300 mg monthly 3
1 other monthly 2
300 mg every 4 weeks 2
300 x 300 mg/15ml every 4 weeks 2

See all 17 dosages

Why patients stopped taking Natalizumab

Multiple reasons could be selected

Reason Patients
Doctor's advice 294
Other 232
Side effects too severe 194
Did not seem to work 153
Personal research 58
Course of treatment ended 29
Expense 28
Change in health plan coverage 18
See all 716 patients who've stopped taking Natalizumab

Duration

Currently taking Natalizumab

Duration Patients
1 - 6 months 6
6 months - 1 year 4
1 - 2 years 13
2 - 5 years 58
5 - 10 years 113
10 years or more 40

Stopped taking Natalizumab

Duration Patients
Less than 1 month 73
1 - 6 months 134
6 months - 1 year 109
1 - 2 years 168
2 - 5 years 189
5 - 10 years 43
10 years or more 6
Adherence
Adherence Evaluations
Always 1366
Usually 56
Sometimes 10
Never taken as prescribed 36
Burden
Burden Evaluations
Very hard to take 50
Somewhat hard to take 179
A little hard to take 431
Not at all hard to take 808
Cost per month
Cost per month Evaluations
$200+ 181
$100-199 50
$50-99 68
$25-49 85
< $25 535
Not specified 549

What people switch to and from

Patients started taking Natalizumab after stopping:

Treatment Patients
Glatiramer acetate (Copaxone) 80
Interferon beta-1a IM Injection (Avonex) 47
Interferon beta-1a SubQ injection (Rebif) 46
Dimethyl fumarate (Tecfidera) 34
Interferon beta-1b SubQ Injection (Betaseron) 26

Show all 17 treatments patients report switching from

Patients stopped taking Natalizumab and switched to:

Treatment Patients
Fingolimod (Gilenya) 41
Dimethyl fumarate (Tecfidera) 40
Ocrelizumab (Ocrevus) 20
Rituximab (Rituxan) 18
Teriflunomide (Aubagio) 14

Show all 18 treatments patients report switching to

Last updated:

111 patient evaluations for Natalizumab

Mar 30, 2018 (Started Jul 01, 2014)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 300 mg/15ml every 4 weeks
Cost: < $25 monthly

  • 0 helpful marks

Jul 9, 2017 (Started Jun 30, 2016)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 300 mg/15ml Monthly

  • 0 helpful marks

Feb 27, 2017 (Started Jan 15, 2011)

  • Effectiveness
    Major (for multiple sclerosis)
  • Effectiveness
    None (for Improve mobility)
  • Effectiveness
    Major (for General health)
  • Side effects
    Moderate (bowel problems, slower gait)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 300 mg/15 mL every 4 weeks
Advice & Tips: I completed almost five years on Tysabri. Unfortunately I was diagnosed with breast cancer this month. had to stop it and move to Rebif.

  • 0 helpful marks
Last updated:
Showing 3 of 111 patient evaluations for Natalizumab