What is Trihexyphenidyl?

Category: Prescription Drugs

Most popular types: Artane Trihexyphen Benzhexol Show all

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See also: Risperidone-Trihexyphenidyl Rispond Plus

Trihexyphenidyl is anti-Parkinson's and anticholinergic agent used as adjunctive treatment of Parkinson's disease and for the treatment of drug-induced extrapyramidal symptoms.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 82 46
Tremor in hands 28 22
Tremor(s) 20 17
Dystonia 4 6
Restlessness (akathisia) 4 3
Stiffness/spasticity 3 2

Show all 29 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 16
Moderate 31
Mild 28
None 21

Commonly reported side effects and conditions associated with Trihexyphenidyl

Side effect Patients Percentage
Cognitive confusion 10
Dry mouth 7
Word fishing 6
Dizziness 4
Sleepiness 4
Auditory hallucinations 2

Show all 45 reported side effects

Dosages

Based on patients currently taking Trihexyphenidyl

Dosage Patients Percentage
2 mg twice daily 3
1 mg daily 2
5 mg twice daily 2
1 mg twice daily 1
2 mg/5 mL daily 1
2 mg daily 1
1 mg three times daily 1
1 mg four times daily 1
4 mg daily 1
2 mg three times daily 1

See all 13 dosages

Why patients stopped taking Trihexyphenidyl

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 28
Doctor's advice 18
Did not seem to work 17
Other 10
Course of treatment ended 3
Personal research 3
Expense 1
See all 60 patients who've stopped taking Trihexyphenidyl

Duration

Currently taking Trihexyphenidyl

Duration Patients Percentage
1 - 2 years 5
2 - 5 years 5
5 - 10 years 4
10 years or more 3

Stopped taking Trihexyphenidyl

Duration Patients Percentage
Less than 1 month 6
1 - 6 months 20
6 months - 1 year 10
1 - 2 years 11
2 - 5 years 11
5 - 10 years 1
10 years or more 3
Adherence
Adherence Evaluations Percentage
Always 64
Usually 24
Sometimes 3
Never taken as prescribed 5
Burden
Burden Evaluations Percentage
Very hard to take 3
Somewhat hard to take 5
A little hard to take 19
Not at all hard to take 69
Cost per month
Cost per month Evaluations Percentage
$200+ 0
$100-199 1
$50-99 0
$25-49 6
< $25 58
Not specified 31

What people switch to and from

Patients started taking Trihexyphenidyl after stopping:

Treatment Patients Percentage
Baclofen (Mylan-Baclofen) 1
Cyclobenzaprine (Flexeril) 1
Gabapentin (Neurontin) 1
Hydroxyzine (Vistaril) 1
Propranolol (Inderal) 1

Show all 6 treatments patients report switching from

Patients stopped taking Trihexyphenidyl and switched to:

Treatment Patients Percentage
Amantadine (Symmetrel) 2
Carbidopa-Levodopa (Sinemet) 2
Entacapone (Comtan) 2
Baclofen (Mylan-Baclofen) 1
Cyclobenzaprine (Flexeril) 1

Show all 7 treatments patients report switching to

Last updated:

10 patient evaluations for Trihexyphenidyl

Jan 9, 2016 (Started Dec 20, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 6 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

May 13, 2012 (Started Apr 28, 2010)

  • Effectiveness
    Moderate (for pd was progressing)
  • Side effects
    Moderate (complete exhaustion, anxious mood)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.5 mg Daily
Advice & Tips: lots of great changes at first, bladder control, sleeping better, less tremoring
Cost: < $25 monthly

  • 0 helpful marks

Mar 25, 2011 (Started Oct 12, 2003)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Severe (cognitive confusion, loss of short term memory)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: I stopped Artane March 2011...the short term memory was causing some major problems in my life
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

Jan 3, 2011 (Started Oct 12, 2003)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (cognitive confusion, loss of short term memory)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 20 mg Daily
Advice & Tips: Artane definitely helps with my tremors but it also cause some short term memory problems
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

Apr 2, 2010 (Started Oct 12, 2003)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (cognitive confusion, loss of short term memory)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 20 mg Daily
Advice & Tips: I was off Artane for several months, by my request. I started again because my tremors started getting bad again. I did not see any improvement in my memory loss while I was off of the artane
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

Nov 20, 2009 (Started Oct 12, 2003)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Severe (cognitive confusion)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Daily
Advice & Tips: Started taking Artane when diagnosed. It helped my tremors, but had a devastating effect on my short term memory. My neuro and I felt like it was time to start weaning me off of Artane on Oct 29,2009. I took my last dose morning of Nov 20, 2009. Went from 5mgs 4xdaily to 2.5 mgs 1xday over 3 weeks. Have not seen any real improvement over short term memory loss but over all feel better physically. My tremors have not increased significantly enough to warrant going back to Artane.
Cost: < $25 monthly
Side effects: cognitive confusion, loss of short term memory

  • 1 helpful mark
Last updated:
Showing 3 of 10 patient evaluations for Trihexyphenidyl