What is Amitriptyline?

Category: Prescription Drugs

Most popular types: Elavil Endep Trepiline Show all

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See also: Amantadine-amitriptyline-baclofen-clonidine-lidocaine-nifedipine-prilocaine Ketoprofen, Bupivacaine, Amitriptyline, Clonidine, Gabapentin , Ketamine, Cyclobenzaprine

Amitriptyline is a tricyclic antidepressant used for the treatment of depression. It may also be used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 1083 739
Fibromyalgia 989 633
Pain 943 607
Depressed mood 211 124
Migraine headaches 171 114

Show all 303 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 288
Moderate 424
Mild 559
None 715

Commonly reported side effects and conditions associated with Amitriptyline

Side effect Patients Percentage
Dry mouth 183
Weight gain 129
Drowsiness 95
Sleepiness 61
Excessive daytime sleepiness (somnolence) 51
Grogginess 47

Show all 271 reported side effects

Dosages

Based on patients currently taking Amitriptyline

Dosage Patients Percentage
25 mg daily 57
10 mg daily 49
50 mg daily 40
20 mg daily 20
75 mg daily 16
30 mg daily 15
100 mg daily 13
200 mg daily 4
150 mg daily 3
10mg as needed 2

See all 25 dosages

Why patients stopped taking Amitriptyline

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 489
Side effects too severe 486
Doctor's advice 273
Other 178
Course of treatment ended 57
Personal research 56
Expense 15
Change in health plan coverage 12
See all 1156 patients who've stopped taking Amitriptyline

Duration

Currently taking Amitriptyline

Duration Patients Percentage
Less than 1 month 2
1 - 6 months 3
6 months - 1 year 6
1 - 2 years 25
2 - 5 years 62
5 - 10 years 69
10 years or more 70

Stopped taking Amitriptyline

Duration Patients Percentage
Less than 1 month 220
1 - 6 months 316
6 months - 1 year 181
1 - 2 years 151
2 - 5 years 189
5 - 10 years 64
10 years or more 40
Adherence
Adherence Evaluations Percentage
Always 1581
Usually 244
Sometimes 74
Never taken as prescribed 87
Burden
Burden Evaluations Percentage
Very hard to take 90
Somewhat hard to take 125
A little hard to take 245
Not at all hard to take 1526
Cost per month
Cost per month Evaluations Percentage
$200+ 7
$100-199 3
$50-99 13
$25-49 29
< $25 1027
Not specified 907

What people switch to and from

Patients started taking Amitriptyline after stopping:

Treatment Patients Percentage
Duloxetine (Cymbalta) 16
Gabapentin (Neurontin) 16
Trazodone (Desyrel) 16
Pregabalin (Lyrica) 11
Zolpidem (Ambien) 11

Show all 72 treatments patients report switching from

Patients stopped taking Amitriptyline and switched to:

Treatment Patients Percentage
Nortriptyline (Pamelor) 30
Gabapentin (Neurontin) 28
Duloxetine (Cymbalta) 18
Pregabalin (Lyrica) 14
Topiramate (Topamax) 11

Show all 61 treatments patients report switching to

Last updated:

154 patient evaluations for Amitriptyline

Jun 20, 2019 (Started May 05, 2017)

  • Effectiveness
    Slight (for pain)
  • Effectiveness
    None (for neuropathy in hands)
  • Effectiveness
    Slight (for neuropathy in feet)
  • Effectiveness
    Slight (for neuropathy)
  • Side effects
    Mild (intoxicated feeling, nausea, migraine headaches)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

May 19, 2017 (Started May 05, 2017)

  • Effectiveness
    Moderate (for neuropathy in feet)
  • Effectiveness
    Slight (for neuropathy in hands)
  • Side effects
    Moderate (intoxicated feeling, nausea, migraine headaches)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

  • 0 helpful marks

May 31, 2019 (Started Jan 15, 2019)

  • Effectiveness
    Slight (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Slight (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily

  • 0 helpful marks

Dec 15, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Slight (for increased need for sleep)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Still have unexpected "depressive episodes" but they are b/c of my Major Depressive Disorder. (chemical imbalance in brain) Sometimes, I have to add an "extra" (100 mg) d/t lack of sleep/quality of sleep. But still think it's one of the best anti-depressants around. The ones that the pharmaceutical companies are cranking out have longer & longer side effects (Any advertised in magazine...takes up 3 pages!) Weight gain is something I have to fight with --along w/ post menopause, hypothyroidism, & clonazepam
Cost: < $25 monthly

Aug 13, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Major (for increased need for sleep)
  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Feeling hung-over in the morning & sudden impact of sleepiness after taken; take. medication right before you have eaten & are ready for bed. Its still the best anti-depressant I've EVER tried!
Cost: < $25 monthly

Dec 15, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Nov 10, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Aug 2, 2016 (Started Apr 19, 2012)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Elavil is becoming unfamiliar with psychiatrists these days; they seem to feel that the old tricylics don't work as well as all the SSRI's that are out there now. Personally, over the vast amount of years with my psychiatrist, we tried everything from A-Z......always came back to Elavil. The SSRI's had terrible side effects & did not work as well. I think it's been quite effective! The weight gain used to be bad until I was dxed w/ Type 2 Diabetes (not on medication/just diet & exercise & glucose monitoring daily) Now I've been losing weight.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 154 patient evaluations for Amitriptyline