What is Amitriptyline?

Category: Prescription Drugs

Most popular types: Elavil Endep Trepiline Show all

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See also: Amantadine-amitriptyline-baclofen-clonidine-lidocaine-nifedipine-prilocaine

Amitriptyline is a tricyclic antidepressant used for the treatment of depression. It may also be used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 1084 740
Fibromyalgia 989 633
Pain 945 606
Depressed mood 212 124
Migraine headaches 171 114

Show all 300 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 287
Moderate 425
Mild 557
None 713

Commonly reported side effects and conditions associated with Amitriptyline

Side effect Patients Percentage
Dry mouth 182
Weight gain 129
Drowsiness 95
Sleepiness 61
Excessive daytime sleepiness (somnolence) 51
Grogginess 47

Show all 270 reported side effects

Dosages

Based on patients currently taking Amitriptyline

Dosage Patients Percentage
25 mg daily 49
10 mg daily 40
50 mg daily 37
20 mg daily 17
30 mg daily 16
75 mg daily 12
100 mg daily 12
150 mg daily 4
200 mg daily 4
5 mg daily 2

See all 23 dosages

Why patients stopped taking Amitriptyline

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 486
Side effects too severe 484
Doctor's advice 272
Other 176
Course of treatment ended 57
Personal research 55
Expense 15
Change in health plan coverage 12
See all 1151 patients who've stopped taking Amitriptyline

Duration

Currently taking Amitriptyline

Duration Patients Percentage
Less than 1 month 1
1 - 6 months 4
6 months - 1 year 12
1 - 2 years 17
2 - 5 years 58
5 - 10 years 65
10 years or more 54

Stopped taking Amitriptyline

Duration Patients Percentage
Less than 1 month 219
1 - 6 months 315
6 months - 1 year 183
1 - 2 years 150
2 - 5 years 186
5 - 10 years 64
10 years or more 40
Adherence
Adherence Evaluations Percentage
Always 1578
Usually 244
Sometimes 74
Never taken as prescribed 86
Burden
Burden Evaluations Percentage
Very hard to take 90
Somewhat hard to take 125
A little hard to take 246
Not at all hard to take 1521
Cost per month
Cost per month Evaluations Percentage
$200+ 7
$100-199 3
$50-99 13
$25-49 28
< $25 1026
Not specified 905

What people switch to and from

Patients started taking Amitriptyline after stopping:

Treatment Patients Percentage
Duloxetine (Cymbalta) 16
Gabapentin (Neurontin) 16
Trazodone (Desyrel) 16
Pregabalin (Lyrica) 11
Zolpidem (Ambien) 11

Show all 71 treatments patients report switching from

Patients stopped taking Amitriptyline and switched to:

Treatment Patients Percentage
Nortriptyline (Pamelor) 29
Gabapentin (Neurontin) 28
Duloxetine (Cymbalta) 18
Pregabalin (Lyrica) 14
Trazodone (Desyrel) 10

Show all 60 treatments patients report switching to

Last updated:

153 patient evaluations for Amitriptyline

Jun 20, 2019 (Started May 05, 2017)

  • Effectiveness
    Slight (for pain)
  • Effectiveness
    None (for neuropathy in hands)
  • Effectiveness
    Slight (for neuropathy in feet)
  • Effectiveness
    Slight (for neuropathy)
  • Side effects
    Mild (intoxicated feeling, nausea, migraine headaches)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

May 19, 2017 (Started May 05, 2017)

  • Effectiveness
    Moderate (for neuropathy in feet)
  • Effectiveness
    Slight (for neuropathy in hands)
  • Side effects
    Moderate (intoxicated feeling, nausea, migraine headaches)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

  • 0 helpful marks

Dec 15, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Slight (for increased need for sleep)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Still have unexpected "depressive episodes" but they are b/c of my Major Depressive Disorder. (chemical imbalance in brain) Sometimes, I have to add an "extra" (100 mg) d/t lack of sleep/quality of sleep. But still think it's one of the best anti-depressants around. The ones that the pharmaceutical companies are cranking out have longer & longer side effects (Any advertised in magazine...takes up 3 pages!) Weight gain is something I have to fight with --along w/ post menopause, hypothyroidism, & clonazepam
Cost: < $25 monthly

Aug 13, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Major (for increased need for sleep)
  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Feeling hung-over in the morning & sudden impact of sleepiness after taken; take. medication right before you have eaten & are ready for bed. Its still the best anti-depressant I've EVER tried!
Cost: < $25 monthly

Dec 15, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Nov 10, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Aug 2, 2016 (Started Apr 19, 2012)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Elavil is becoming unfamiliar with psychiatrists these days; they seem to feel that the old tricylics don't work as well as all the SSRI's that are out there now. Personally, over the vast amount of years with my psychiatrist, we tried everything from A-Z......always came back to Elavil. The SSRI's had terrible side effects & did not work as well. I think it's been quite effective! The weight gain used to be bad until I was dxed w/ Type 2 Diabetes (not on medication/just diet & exercise & glucose monitoring daily) Now I've been losing weight.
Cost: < $25 monthly

  • 0 helpful marks

Nov 12, 2018 (Started Jul 08, 1995)

  • Effectiveness
    Moderate (for excess saliva)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: It works for me at drying up saliva.
Cost: < $25 monthly

Feb 1, 2016 (Started Jul 08, 1995)

  • Effectiveness
    Slight (for excess saliva)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily

Aug 15, 2015 (Started Jul 08, 1995)

  • Effectiveness
    Major (for excess saliva)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 153 patient evaluations for Amitriptyline