What is Pyridostigmine?

Category: Prescription Drugs

Most popular types: Mestinon Mestinon Timespan Kalymin 60N

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Pyridostigmine is an acetylcholinesterase inhibitor used for the symptomatic treatment of myaesthenia gravis and as an antidote for nondepolarizing neuromuscular blockers.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Myasthenia gravis 141 78
Fatigue 21 14
Postural orthostatic tachycardia syndrome 10 6
Dysautonomia 7 7
Lambert-Eaton myasthenic syndrome 7 1
Drooping eyelid (ptosis) 6 4

Show all 59 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 7
Moderate 21
Mild 31
None 55

Commonly reported side effects and conditions associated with Pyridostigmine

Side effect Patients Percentage
Diarrhea 20
Nausea 6
Excess saliva 3
Stomach pain 3
Sweating 3
Abdominal cramps 2

Show all 47 reported side effects

Dosages

Based on patients currently taking Pyridostigmine

Dosage Patients Percentage
60 mg four times daily 4
180 mg daily 3
60 mg three times daily 3
30 mg three times daily 2
60 mg five times daily 2
120 mg four times daily 2
1 mg twice daily 1
15 mg daily 1
30 mg daily 1
15 mg three times daily 1

See all 18 dosages

Why patients stopped taking Pyridostigmine

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 19
Doctor's advice 13
Side effects too severe 11
Other 9
Expense 2
Course of treatment ended 1
Personal research 1
See all 39 patients who've stopped taking Pyridostigmine

Duration

Currently taking Pyridostigmine

Duration Patients Percentage
1 - 6 months 1
6 months - 1 year 2
1 - 2 years 2
2 - 5 years 9
5 - 10 years 10
10 years or more 3

Stopped taking Pyridostigmine

Duration Patients Percentage
Less than 1 month 6
1 - 6 months 9
6 months - 1 year 9
1 - 2 years 5
2 - 5 years 5
5 - 10 years 3
10 years or more 2
Adherence
Adherence Evaluations Percentage
Always 76
Usually 24
Sometimes 8
Never taken as prescribed 6
Burden
Burden Evaluations Percentage
Very hard to take 7
Somewhat hard to take 7
A little hard to take 21
Not at all hard to take 79
Cost per month
Cost per month Evaluations Percentage
$200+ 1
$100-199 1
$50-99 1
$25-49 17
< $25 36
Not specified 58

What people switch to and from

Patients started taking Pyridostigmine after stopping:

Treatment Patients Percentage
Meclizine (Meclizine OTC) 1
Metoprolol (Metoprolol Tartrate) 1
Prednisone (Deltasone) 1
Senna (Senokot) 1

Patients stopped taking Pyridostigmine and switched to:

Treatment Patients Percentage
Droxidopa (Northera) 1
Fludrocortisone (Florinef) 1
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 1
Midodrine (ProAmatine) 1
Mycophenolate mofetil (CellCept) 1

Show all 6 treatments patients report switching to

Last updated:

3 patient evaluations for Pyridostigmine

Mar 1, 2011 (Started Aug 01, 2006)

  • Effectiveness
    None (for fatigue)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks

Apr 8, 2009 (Started Apr 08, 2009)

  • Effectiveness
    Moderate (for Other)
  • Effectiveness
    Moderate (for fatigue)
  • Effectiveness
    None (for double vision (diplopia))
  • Side effects
    Moderate (excess mucus)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 30 mg All the time (24/7)
Advice & Tips: The doctor prescribed way too much for me initially. I was to take 60 mg every four hours, well by the second dose I had 120 mg and I was rigid, weak, could not form words with my mouth and tongue, I sounded like I inhaled helium, my face muscles were not working together....I hyperventilated and my anxiety shot through the roof !A trip to the ER, with several IV's and a re-evaluation over the phone with the doc. I now take 1/2-1 30mg tablet as needed. I am monitoring symptoms...no vision improvement but it does help with speaking, choking and neck pain.
Cost: $50-99 monthly
Side effects: excess mucus

  • 0 helpful marks

Aug 19, 2008 (Started Dec 17, 2005)

  • Effectiveness
    Major (for Other)
  • Effectiveness
    None (for atrophy of upper body muscles)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 180 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 3 patient evaluations for Pyridostigmine