What is Promethazine?

Category: Prescription Drugs

Most popular types: Phenergan Promethegan Phenadoz Show all

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See also: Promethazine DM

Promethazine is an antiemetic and antihistamine. It is used to relieve the symptoms of allergic reactions, nausea, motion sickness. It is also use as a sedative, as adjunctive therapy for postoperative pain, anesthetic and anaphylactic reactions.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Nausea 271 82
Gastroparesis 52 13
Migraine headaches 40 18
Insomnia 18 5
Migraine 12 9

Show all 63 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 15
Moderate 34
Mild 63
None 76

Commonly reported side effects and conditions associated with Promethazine

Side effect Patients Percentage
Drowsiness 36
Sleepiness 10
Excessive daytime sleepiness (somnolence) 6
Fatigue 6
Tiredness 6
Dry mouth 3

Show all 45 reported side effects

Dosages

Based on patients currently taking Promethazine

Dosage Patients Percentage
25mg as needed 11
25 mg daily 6
25mg/mL as needed 4
25 mg three times daily 2
12.5mg as needed 2
1mg as needed 2
25 mg twice daily 1
25 mg four times daily 1
312.5 mg twice daily 1
1other as needed 1

See all 12 dosages

Why patients stopped taking Promethazine

Multiple reasons could be selected

Reason Patients Percentage
Course of treatment ended 35
Doctor's advice 31
Other 28
Did not seem to work 27
Side effects too severe 25
Change in health plan coverage 3
Expense 1
See all 122 patients who've stopped taking Promethazine

Duration

Currently taking Promethazine

Duration Patients Percentage
1 - 6 months 1
6 months - 1 year 3
2 - 5 years 8
5 - 10 years 10
10 years or more 12

Stopped taking Promethazine

Duration Patients Percentage
Less than 1 month 34
1 - 6 months 20
6 months - 1 year 16
1 - 2 years 18
2 - 5 years 19
5 - 10 years 10
10 years or more 7
Adherence
Adherence Evaluations Percentage
Always 118
Usually 33
Sometimes 28
Never taken as prescribed 9
Burden
Burden Evaluations Percentage
Very hard to take 3
Somewhat hard to take 13
A little hard to take 22
Not at all hard to take 150
Cost per month
Cost per month Evaluations Percentage
$200+ 3
$100-199 0
$50-99 0
$25-49 5
< $25 94
Not specified 86

What people switch to and from

Patients started taking Promethazine after stopping:

Treatment Patients Percentage
Ondansetron (Zofran) 15
Meclizine (Meclizine OTC) 2
Quetiapine (Seroquel) 2
Carbamazepine (Tegretol) 1
Gabapentin (Neurontin) 1

Show all 8 treatments patients report switching from

Patients stopped taking Promethazine and switched to:

Treatment Patients Percentage
Ondansetron (Zofran) 22
Prochlorperazine (Compazine) 3
Cetirizine-pseudoephedrine (Zyrtec-D) 1
Medical marijuana (Cannabidiol/Tetrahydrocannabinol Balanced Mixture) 1
Metoclopramide (Reglan) 1

Show all 8 treatments patients report switching to

Last updated:

20 patient evaluations for Promethazine

May 23, 2020 (Started Jan 21, 2020)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Severe (grogginess in morning)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Advice & Tips: If you plan to take Promethazine as a sleep aid beware that it may take several hours to put you to sleep and doesn't seem to work out of your system in time to feel well rested in the morning.
Cost: < $25 monthly

  • 0 helpful marks

Apr 6, 2018 (Started Mar 01, 2017)

  • Effectiveness
    Major (for nausea)
  • Side effects
    Mild (restless legs syndrome, drowsiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks

Feb 15, 2016 (Started Sep 26, 2015)

  • Effectiveness
    Major (for nausea and vomiting)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 20 patient evaluations for Promethazine